Protein Alignment KCNC1 and Shawl

DIOPT Version :10

• Sequence 1: NP_001106212.1
• Gene: KCNC1 / 3746
• HGNCID: 6233
• Length: 585
• Species: Homo sapiens
• Sequence 2: NP_001097131.2
• Gene: Shawl / 5740840
• FlyBaseID: FBgn0085395
• Length: 937
• Species: Drosophila melanogaster
• Alignment Length: 572
• Identity: 228/572 - (39%)
• Similarity: 307/572 - (53%)
• Gaps: 135/572 - (23%)

Human     5 DESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRHPGVFAHILN 69
            |...||::||.|.|::||::||:.:|.|||:.|.|..|    :|||..:|:|||||||||..|||
  Fly     2 DGENRIILNVSGIRYETYKATLKKIPATRLSRLTEALA----NYDPVLNEYFFDRHPGVFTQILN 62

Human    70 YYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAPLDNSADDA 134
            ||||||||.|.||||||:||||.|||:|...||||||.||..|||.:..|     |.||..  |.
  Fly    63 YYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTL-----AILDKL--DI 120

Human   135 DADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFEDPYSSRYARYVAFASLFF 199
            :.:.|       .|.::.:.....::........|:|.:|:|||:|::|.||..|:.||..|:||
  Fly   121 ENEKP-------TEEQIARLFGFEEALSNGELNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFF 178

Human   200 ILVSITTFCLETHERF-----------------------NP------------------------ 217
            |.||:.:|||:||..|                       :|
  Fly   179 IFVSVISFCLKTHPGFRVDLPSGAHDAHGPGAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSIGP 243

Human   218 ---IVN--------------KTEIENVRNGTQVRYYRE-------------------------AE 240
               :.|              .|.|..::.|.:.|..|.                         .|
  Fly   244 TFRVTNYTSYSSGNFTASGQATPIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIE 308

Human   241 T-----EAFLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSS 300
            |     |||. |:|.||.|||..|.::|:|..||..:|||:.:|||||.|.|.||.:|      .
  Fly   309 TYGQPHEAFF-YVELVCNVWFFIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFYTDV------M 366

Human   301 KAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYY 365
            :...:..|.|.....|||:|:||||||..|||:|.||.:||..|..||:.||.||::.||::.||
  Fly   367 QRMGEYTGLLEAFSIVRIMRLFKLTRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASLAYY 431

Human   366 AERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAM 430
            ||::...|::       .||:||:|.|||:|||||:||||:.|:|:.||.||||||||||||||:
  Fly   432 AEKLQDNPDN-------QFKSIPLGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIAL 489

Human   431 PVPVIVNNFGMYYSLAMAKQKLPKKKKKHIP--RPPQLGSPNYCKSVVNSPH 480
            ||||||:||.|:||...|:.|||||:::.:|  :|.:...|       .:||
  Fly   490 PVPVIVSNFSMFYSHTQARSKLPKKRRRVLPVEQPRRKREP-------TAPH 534

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNC1	NP_001106212.1	BTB_KCNC1_3	6..122	CDD:349721	68/115 (59%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	121..147		5/25 (20%)
		Ion_trans	189..447	CDD:459842	132/351 (38%)
		Selectivity filter. /evidence=ECO:0000250	400..405		3/4 (75%)
Shawl	NP_001097131.2	BTB_Shaw-like	4..115	CDD:349723	69/119 (58%)
		Ion_trans	307..506	CDD:459842	110/212 (52%)