Protein Alignment KCNC1 and Shal

DIOPT Version :10

• Sequence 1: NP_001106212.1
• Gene: KCNC1 / 3746
• HGNCID: 6233
• Length: 585
• Species: Homo sapiens
• Sequence 2: NP_001097646.1
• Gene: Shal / 40129
• FlyBaseID: FBgn0005564
• Length: 571
• Species: Drosophila melanogaster
• Alignment Length: 598
• Identity: 185/598 - (30%)
• Similarity: 288/598 - (48%)
• Gaps: 114/598 - (19%)

Human     6 ESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRHPGVFAHILNY 70
            :.|:::|||.|.|.:|:|:||...|.|.|.     .....|.||....|:||||.|.:|.|||||
  Fly    39 DDEKLLINVSGRRFETWRNTLEKYPDTLLG-----SNEREFFYDEDCKEYFFDRDPDIFRHILNY 98

Human    71 YRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHR--DAEEALDSFGGAPLDNSADD 133
            |||||||.|...|...|:|||||:||....:..||:..||..:  :||..:|
  Fly    99 YRTGKLHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRDRKRENAERLMD------------- 150

Human   134 ADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFEDPYSSRYARYVAFASLF 198
               |...::|| ::..::|                  ..:.::|..||:|::|..|....:.:.|
  Fly   151 ---DKLSENGD-QNLQQLT------------------NMRQKMWRAFENPHTSTSALVFYYVTGF 193

Human   199 FILVSITTFCLETHERFNPIVNKTEIENVRNGT---QVRYYREAETEAFLTYIEGVCVVWFTFEF 260
            ||.||:....:||    .|..::..    |.||   ..||      :.....::..||:.||.|:
  Fly   194 FIAVSVMANVVET----VPCGHRPG----RAGTLPCGERY------KIVFFCLDTACVMIFTAEY 244

Human   261 LMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLT 325
            |:|:...|::.:|:::.::|||.|||:|:|:.:|::.     ..||.|....:|..|:.||||.:
  Fly   245 LLRLFAAPDRCKFVRSVMSIIDVVAIMPYYIGLGITD-----NDDVSGAFVTLRVFRVFRIFKFS 304

Human   326 RHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGAQPNDPSASEHTHFKNIPIG 390
            ||..|||:||:||::..:|...|:..||:.::||||:::|||:         ....|:|.:||..
  Fly   305 RHSQGLRILGYTLKSCASELGFLVFSLAMAIIIFATVMFYAEK---------NVNGTNFTSIPAA 360

Human   391 FWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKK 455
            ||:.:|||||||||||.|:|.:|.:||.:|:|:|||.||:||||||:||...|.......|...:
  Fly   361 FWYTIVTMTTLGYGDMVPETIAGKIVGGVCSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRKAQ 425

Human   456 KKKHIPR----PPQLGSPNYCKSVVNSPHHSTQSDTCPL----AQEEILEINRADSKLNGEVAKA 512
            :|..:.|    ....|:....|........:.|.....|    ..|:|.|:..
  Fly   426 RKARLARIRIAKASSGAAFVSKKKAAEARWAAQESGIELDDNYRDEDIFELQH------------ 478

Human   513 ALANEDCPHIDQAL--TPDE-----GLPFTRSGTRERYGPCFLLSTGEYACPPGGGMRKDLC--- 567
                   .|:.:.|  |.|.     .:||  :|..:|.|....:::..::.....|:.:..|
  Fly   479 -------HHLLRCLEKTTDREFVELEIPF--NGQPKRPGSPSPMASPAHSTNSAAGLLQSCCGRC 534

Human   568 --KESPVIAKYMP 578
              :......||||
  Fly   535 CSQRYQACGKYMP 547

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNC1	NP_001106212.1	BTB_KCNC1_3	6..122	CDD:349721	52/117 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	121..147		3/25 (12%)
		Ion_trans	189..447	CDD:459842	99/260 (38%)
		Selectivity filter. /evidence=ECO:0000250	400..405		4/4 (100%)
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	49/109 (45%)
		Ion_trans	188..415	CDD:459842	98/254 (39%)
		DUF3399	471..535	CDD:463381	14/84 (17%)