Protein Alignment KCNC1 and Shab

DIOPT Version :10

• Sequence 1: NP_001106212.1
• Gene: KCNC1 / 3746
• HGNCID: 6233
• Length: 585
• Species: Homo sapiens
• Sequence 2: NP_001189037.1
• Gene: Shab / 38352
• FlyBaseID: FBgn0262593
• Length: 1607
• Species: Drosophila melanogaster
• Alignment Length: 493
• Identity: 176/493 - (35%)
• Similarity: 256/493 - (51%)
• Gaps: 80/493 - (16%)

Human     7 SERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHF-----DYDPRADEFFFDRHPGVFAH 66
            :.|:.|||||.||:....||..||.|||..|.|...|...     ||....:|:||||||..|:.
  Fly   306 NSRVSINVGGVRHEVLWRTLERLPHTRLGRLRECTTHEAIVELCDDYSLADNEYFFDRHPKSFSS 370

Human    67 ILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQ-----HRDAEEALDSFGGAP 126
            |||:|||||||...::|...:.::|.:||:||..:|.||...|.|     |.:..:..:|.
  Fly   371 ILNFYRTGKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYHQRKENVHEEMRKEAESL---- 431

Human   127 LDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFEDPYSSRYARY 191
               ...|.:..|.|...:                           :|..:|.|.|.|.:|..||.
  Fly   432 ---RQRDEEEFGEGKCAE---------------------------YQKYLWELLEKPNTSFAARV 466

Human   192 VAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETEAFLTYIEGVCVVWF 256
            :|..|:.||::|.....|.|         ..:::::.|||       .:....|..:|.||:.||
  Fly   467 IAVISILFIVLSTIALTLNT---------LPQLQHIDNGT-------PQDNPQLAMVEAVCITWF 515

Human   257 TFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAA---KDVLGFLRVVRFVRI 318
            |.|:::|....|:|.:|.|..|||||.:||||:::.:.|...:..|.   :||...::|.|.:||
  Fly   516 TLEYILRFSASPDKWKFFKGGLNIIDLLAILPYFVSLFLLETNKNATDQFQDVRRVVQVFRIMRI 580

Human   319 LRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGAQPNDPSASEHTH 383
            |||.||.||..||:.||.|||.|..|..||::|||:|||||:::.|:||:         ..:.|.
  Fly   581 LRILKLARHSTGLQSLGFTLRNSYKELGLLMLFLAMGVLIFSSLAYFAEK---------DEKDTK 636

Human   384 FKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMA 448
            |.:||..||||.:||||:||||:||.|..|.::|.:|.:.|||.||:|:|:|||||..:|...|.
  Fly   637 FVSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTVCCICGVLVIALPIPIIVNNFAEFYKNQMR 701

Human   449 KQKLPKKKKKHIPRPPQLGSPNYCKSVVNSPHHSTQSD 486
            ::| ..|:::.:.|..:.||       :.|.||....|
  Fly   702 REK-ALKRREALDRAKREGS-------IVSFHHINLKD 731

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNC1	NP_001106212.1	BTB_KCNC1_3	6..122	CDD:349721	50/124 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	121..147		4/25 (16%)
		Ion_trans	189..447	CDD:459842	106/260 (41%)
		Selectivity filter. /evidence=ECO:0000250	400..405		3/4 (75%)
Shab	NP_001189037.1	BTB_POZ_Shab-like	306..414	CDD:349720	47/107 (44%)
		Ion_trans	464..700	CDD:459842	106/260 (41%)