DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment twz and KCTD15

DIOPT Version :9

Sequence 1:	NP_001246449.1	Gene:	twz / 37456	FlyBaseID:	FBgn0034636	Length:	367	Species:	Drosophila melanogaster
Sequence 2:	NP_001123466.1	Gene:	KCTD15 / 79047	HGNCID:	23297	Length:	283	Species:	Homo sapiens

Alignment Length:	269	Identity:	129/269 - (47%)
Similarity:	175/269 - (65%)	Gaps:	34/269 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 GASSAGASSYLHGNHKPIT-----GIPCVAAASRYTAPVHIDVGGTIYTSSLETLTKYPESKLAK 163
            |.:..|..|.|.....|::     |||..|..::..|||||||||.:|||||.||||||:|::::
Human    20 GTAEGGNMSRLSLTRSPVSPLAAQGIPLPAQLTKSNAPVHIDVGGHMYTSSLATLTKYPDSRISR 84

  Fly   164 LFNGQIPIVLDSLKQHYFIDRDGGMFRHILNFMRNSRLLIAEDFPDLELLLEEARYYEVEPMIKQ 228
            ||||..|||||||||||||||||.:||::|:|:|.|:||:.:||.|..||.||||||:::||:::
Human    85 LFNGTEPIVLDSLKQHYFIDRDGEIFRYVLSFLRTSKLLLPDDFKDFSLLYEEARYYQLQPMVRE 149

  Fly   229 LESMRKDRVRNGNYLVAPPTPPARHIKTSPRTSASPECNYEVVALHISPDLGERIMLSAERALLD 293
            ||..::::.:.                   |.|.:.:|    :.:.::|||||||.||.|:||::
Human   150 LERWQQEQEQR-------------------RRSRACDC----LVVRVTPDLGERIALSGEKALIE 191

  Fly   294 ELFPEASQATQSSRSGVSWNQGDWGQIIRFPLNGYCKLNSVQVLTRLLNAGFTIEASVGG----Q 354
            |:|||......:| ....||| |...:|||||||||:|||||||.||...||::.||.||    .
Human   192 EVFPETGDVMCNS-VNAGWNQ-DPTHVIRFPLNGYCRLNSVQVLERLFQRGFSVAASCGGGVDSS 254

  Fly   355 QFSEYLLAR 363
            |||||:|.|
Human   255 QFSEYVLCR 263

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
twz	NP_001246449.1	BTB_POZ_KCTD1-like	137..230	CDD:349670	61/92 (66%)
KCTD15	NP_001123466.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32		4/11 (36%)
KCTD15	NP_001123466.1	BTB_POZ_KCTD15	55..153	CDD:349696	65/97 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156331
Domainoid	1	1.000	135	1.000	Domainoid score	I4984
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11450
Inparanoid	1	1.050	238	1.000	Inparanoid score	I3374
Isobase	1	0.950	-	0	Normalized mean entropy	S4982
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D412532at33208
OrthoFinder	1	1.000	-	-		FOG0002897
OrthoInspector	1	1.000	-	-		otm41604
orthoMCL	1	0.900	-	-		OOG6_108738
Panther	1	1.100	-	-	LDO	PTHR14499
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5816
SonicParanoid	1	1.000	-	-		X1912
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.840