DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment twz and Kctd6

DIOPT Version :9

Sequence 1:	NP_001246449.1	Gene:	twz / 37456	FlyBaseID:	FBgn0034636	Length:	367	Species:	Drosophila melanogaster
Sequence 2:	NP_001292865.1	Gene:	Kctd6 / 71393	MGIID:	1918643	Length:	237	Species:	Mus musculus

Alignment Length:	98	Identity:	47/98 - (47%)
Similarity:	69/98 - (70%)	Gaps:	1/98 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   136 PVHIDVGGTIYTSSLETLTKYPESKLAKLFNGQIPIVLDSLKQHYFIDRDGGMFRHILNFMRNSR 200
            ||.::|||.:||:||.|||:||:|.|..:|.|..|...|. :.:|||||||.:||::|||:|.|.
Mouse    13 PVTLNVGGHLYTTSLTTLTRYPDSMLGAMFGGDFPTARDP-QGNYFIDRDGPLFRYVLNFLRTSE 76

  Fly   201 LLIAEDFPDLELLLEEARYYEVEPMIKQLESMR 233
            |.:..||.:.:||.:||.:|::||:|:.|...|
Mouse    77 LTLPLDFKEFDLLRKEADFYQIEPLIQCLNDPR 109

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
twz	NP_001246449.1	BTB_POZ_KCTD1-like	137..230	CDD:349670	44/92 (48%)
Kctd6	NP_001292865.1	Interaction with ANK1 isoform Mu7. /evidence=ECO:0000250\|UniProtKB:Q8NC69	1..104		45/91 (49%)
		BTB_POZ	10..113	CDD:365784	47/98 (48%)
		Interaction with CUL3. /evidence=ECO:0000250\|UniProtKB:Q8NC69	10..110		47/98 (48%)
		Interaction with USP21. /evidence=ECO:0000250\|UniProtKB:Q8NC69	113..187
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846735
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2723
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740