DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment twz and kcnd2

DIOPT Version :9

Sequence 1:	NP_001246449.1	Gene:	twz / 37456	FlyBaseID:	FBgn0034636	Length:	367	Species:	Drosophila melanogaster
Sequence 2:	NP_001076336.1	Gene:	kcnd2 / 570188	ZFINID:	ZDB-GENE-041210-70	Length:	630	Species:	Danio rerio

Alignment Length:	282	Identity:	63/282 - (22%)
Similarity:	105/282 - (37%)	Gaps:	78/282 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 SAGASSYLHGNHKPITGIPCVAAASRYTAP----------VHIDVGGTIYTSSLETLTKYPESKL 161
            :||.:::|........|...||:|.....|          :.::|.||.:.:...||.:||::.|
Zfish     2 AAGVAAWLPFARAAAIGWMPVASAPMPPPPRDKKRGQDGLIILNVSGTRFQTWRNTLERYPDTLL 66

  Fly   162 AK-----LFNGQIPIVLDSLKQHYFIDRDGGMFRHILNFMRNSRLLIAEDFPDLELLL---EEAR 218
            ..     .|:.:        ...||.|||..:|||||||.|..:|    .:|..|.:.   ||..
Zfish    67 GSTERDFFFHEE--------TNEYFFDRDPDIFRHILNFYRTGKL----HYPRHECISAYDEELA 119

  Fly   219 YYEVEPMI------KQLESMRKDRVR---------NGNYLVAPPTPPARHI---KTSPRTSASPE 265
            ::.:.|.|      ::.:..|::...         |.|.||.|.......:   ..:|.||....
Zfish   120 FFGIIPEIIGDCCYEEYKDRRRENAERIQDDEENDNNNDLVMPDLSFRESMWRAFENPHTSTMAL 184

  Fly   266 CNYEVVALHISPDLGERIMLSAERALLDELFPEASQATQSSRSGVSWNQG---DWGQIIRFPLNG 327
            ..|.|....|:..:...::         |..|          .|:|.|:.   ..|:  |:.|..
Zfish   185 VFYYVTGFFIAVSVMANVV---------ETVP----------CGISLNRAKELSCGE--RYALAF 228

  Fly   328 YC------KLNSVQVLTRLLNA 343
            :|      .:.:|:.|.||:.|
Zfish   229 FCLDTACVMIFTVEYLLRLIAA 250

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
twz	NP_001246449.1	BTB_POZ_KCTD1-like	137..230	CDD:349670	29/106 (27%)
kcnd2	NP_001076336.1	Shal-type	3..28	CDD:288455	7/24 (29%)
		BTB	42..139	CDD:197585	29/108 (27%)
		BTB_2	42..131	CDD:280393	29/100 (29%)
		Ion_trans	228..416	CDD:278921	6/23 (26%)
		Ion_trans_2	330..410	CDD:285168
		DUF3399	444..548	CDD:288712
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910