DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment twz and shkbp1

DIOPT Version :9

Sequence 1:	NP_001246449.1	Gene:	twz / 37456	FlyBaseID:	FBgn0034636	Length:	367	Species:	Drosophila melanogaster
Sequence 2:	XP_001920935.4	Gene:	shkbp1 / 562395	ZFINID:	ZDB-GENE-130415-1	Length:	841	Species:	Danio rerio

Alignment Length:	177	Identity:	56/177 - (31%)
Similarity:	87/177 - (49%)	Gaps:	24/177 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 VHIDVGGTIYTSSLETLTKYPESKLAKLFNGQIPIVLDSLKQHYFIDRDGGMFRHILNFMRNSRL 201
            :|::|||..:::|.:|||..|:|..:.|.:|:|..:.|.... .|||||..:|..||||:|...|
Zfish     8 IHLNVGGKRFSTSRQTLTWVPDSFFSSLLSGRISTLKDETGA-IFIDRDPSLFAPILNFLRTKEL 71

  Fly   202 LIAEDFP---DLELLLEEARYYEVEPMIKQLESMRK-DRVRNGNYL----VAPPTPPA----RHI 254
                 .|   |:.||:.||.:|.:.|::::|:...: ||...||.|    :.||..|.    ||.
Zfish    72 -----HPRSIDVHLLIHEAEFYGITPLVRKLQLCDELDRSSCGNVLFNGYLPPPVYPVKRRNRHS 131

  Fly   255 KTSPRTSASPECNYEVVALHIS----PDLGERIMLSAERALLDELFP 297
            ...|:.........|...:..|    |:||...:|.  ||.::|..|
Zfish   132 VAGPQFMGGRSGPVERAPVRRSNTMPPNLGNAGILG--RAAVEERVP 176

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
twz	NP_001246449.1	BTB_POZ_KCTD1-like	137..230	CDD:349670	34/95 (36%)
shkbp1	XP_001920935.4	BTB	6..96	CDD:197585	34/93 (37%)
		BTB_2	8..100	CDD:280393	35/97 (36%)
		WD40	308..>569	CDD:225201
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910