DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment twz and kctd1

DIOPT Version :9

Sequence 1:	NP_001246449.1	Gene:	twz / 37456	FlyBaseID:	FBgn0034636	Length:	367	Species:	Drosophila melanogaster
Sequence 2:	XP_009292901.1	Gene:	kctd1 / 555637	ZFINID:	ZDB-GENE-040724-194	Length:	754	Species:	Danio rerio

Alignment Length:	371	Identity:	154/371 - (41%)
Similarity:	208/371 - (56%)	Gaps:	65/371 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 SPLTVDSSCPKRKKCDMDRERERDVKALEPRDL----------SSTGRIYARSDIKISSSPTVSP 68
            ||.||:.:.....:.:::.:.::.| ...||.|          :|..|..||:|     :|||:.
Zfish   410 SPETVNGAHVLHCEDELELKPQKQV-TKRPRTLVYPVSVAGPGASPKRQCARAD-----TPTVTA 468

  Fly    69 TISNSSSPTPTPPASSSVTPLGLPGAVAAAAAAVGGASSAGASSYLHGNHKPIT-----GIPCVA 128
            .:|:...|..:|..        ||       :....::|.|.|:.....|.|::     |||..|
Zfish   469 RVSSRCEPGESPHM--------LP-------SQENRSNSVGMSTRPILAHSPVSPLGTAGIPTPA 518

  Fly   129 AASRYTAPVHIDVGGTIYTSSLETLTKYPESKLAKLFNGQIPIVLDSLKQHYFIDRDGGMFRHIL 193
            ..::..|||||||||.:|||||.||||||||::.:||:|..|||||||||||||||||.|||:||
Zfish   519 QLTKANAPVHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVLDSLKQHYFIDRDGHMFRYIL 583

  Fly   194 NFMRNSRLLIAEDFPDLELLLEEARYYEVEPMIKQLESMRKDRVRNGNYLVAPPTPPARHIKTSP 258
            ||:|.|:|||.:||.|..||.|||||::::|:..:||..|.:                   :.|.
Zfish   584 NFLRTSKLLIPDDFKDYSLLYEEARYFQLQPLQVELERWRSE-------------------QDSR 629

  Fly   259 RTSASPECNYEVVALHISPDLGERIMLSAERALLDELFPEASQATQSSRSGVSWNQGDWGQIIRF 323
            .||...||    |.:.::|:|||||.||.::||::::|||......:| ....||. |...:|||
Zfish   630 FTSRMCEC----VVVRVAPELGERITLSGDKALIEDIFPEIGDVMCNS-VNAGWNH-DSTHVIRF 688

  Fly   324 PLNGYCKLNSVQVLTRLLNAGFTIEASVGG----QQFSEYLLARRV 365
            ||||||.|||||||.||...||.|.||.||    .|||||:|.|.|
Zfish   689 PLNGYCHLNSVQVLERLQQRGFEIAASCGGGVDSTQFSEYVLRREV 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
twz	NP_001246449.1	BTB_POZ_KCTD1-like	137..230	CDD:349670	63/92 (68%)
kctd1	XP_009292901.1	DUF3504	218..372	CDD:288835
		BTB	527..626	CDD:197585	66/117 (56%)
		BTB	527..619	CDD:295341	63/91 (69%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591944
Domainoid	1	1.000	136	1.000	Domainoid score	I4873
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	235	1.000	Inparanoid score	I3365
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D412532at33208
OrthoFinder	1	1.000	-	-		FOG0002897
OrthoInspector	1	1.000	-	-		otm24279
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14499
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5816
SonicParanoid	1	1.000	-	-		X1912
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.990