DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment twz and Kctd15

DIOPT Version :9

Sequence 1:	NP_001246449.1	Gene:	twz / 37456	FlyBaseID:	FBgn0034636	Length:	367	Species:	Drosophila melanogaster
Sequence 2:	NP_001102611.1	Gene:	Kctd15 / 499129	RGDID:	1583737	Length:	283	Species:	Rattus norvegicus

Alignment Length:	281	Identity:	132/281 - (46%)
Similarity:	178/281 - (63%)	Gaps:	34/281 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 PGAVAAAAAAVGGASSAGASSYLHGNHKPIT-----GIPCVAAASRYTAPVHIDVGGTIYTSSLE 151
            |...:..|....|.:..|..|.|.....|::     |||..|..::..|||||||||.:|||||.
  Rat     8 PSGSSLNAHGSSGTAEGGNMSRLSLTRSPVSPLAAQGIPLPAQLTKANAPVHIDVGGHMYTSSLA 72

  Fly   152 TLTKYPESKLAKLFNGQIPIVLDSLKQHYFIDRDGGMFRHILNFMRNSRLLIAEDFPDLELLLEE 216
            ||||||:|::::||||..|||||||||||||||||.:||:||:|:|.|:||:.:||.|..||.||
  Rat    73 TLTKYPDSRISRLFNGTEPIVLDSLKQHYFIDRDGEIFRYILSFLRTSKLLLPDDFKDFNLLYEE 137

  Fly   217 ARYYEVEPMIKQLESMRKDRVRNGNYLVAPPTPPARHIKTSPRTSASPECNYEVVALHISPDLGE 281
            ||||:::||:::||..::::.:.                   |.|.:.:|    :.:.::|||||
  Rat   138 ARYYQLQPMVRELERWQQEQEQR-------------------RRSRACDC----LVVRVTPDLGE 179

  Fly   282 RIMLSAERALLDELFPEASQATQSSRSGVSWNQGDWGQIIRFPLNGYCKLNSVQVLTRLLNAGFT 346
            ||.||.|:||::|:|||......:| ....||| |...:|||||||||:|||||||.||...||:
  Rat   180 RIALSGEKALIEEVFPETGDVMCNS-VNAGWNQ-DPTHVIRFPLNGYCRLNSVQVLERLFQRGFS 242

  Fly   347 IEASVGG----QQFSEYLLAR 363
            :.||.||    .|||||:|.|
  Rat   243 VAASCGGGVDSSQFSEYVLCR 263

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
twz	NP_001246449.1	BTB_POZ_KCTD1-like	137..230	CDD:349670	62/92 (67%)
Kctd15	NP_001102611.1	BTB_POZ_KCTD15	55..153	CDD:349696	66/97 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350263
Domainoid	1	1.000	136	1.000	Domainoid score	I4799
eggNOG	1	0.900	-	-		E1_KOG2723
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11450
Inparanoid	1	1.050	239	1.000	Inparanoid score	I3277
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D412532at33208
OrthoFinder	1	1.000	-	-		FOG0002897
OrthoInspector	1	1.000	-	-		otm45727
orthoMCL	1	0.900	-	-		OOG6_108738
Panther	1	1.100	-	-	LDO	PTHR14499
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1912
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.760