DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment twz and kctd15

DIOPT Version :9

Sequence 1:	NP_001246449.1	Gene:	twz / 37456	FlyBaseID:	FBgn0034636	Length:	367	Species:	Drosophila melanogaster
Sequence 2:	NP_989239.1	Gene:	kctd15 / 394848	XenbaseID:	XB-GENE-944069	Length:	255	Species:	Xenopus tropicalis

Alignment Length:	245	Identity:	126/245 - (51%)
Similarity:	164/245 - (66%)	Gaps:	29/245 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 GIPCVAAASRYTAPVHIDVGGTIYTSSLETLTKYPESKLAKLFNGQIPIVLDSLKQHYFIDRDGG 187
            |||..|..::..|||||||||.:|||||.||||||:|::::||||..|||||||||||||||||.
Frog    18 GIPLPAQLTKSNAPVHIDVGGHMYTSSLATLTKYPDSRISRLFNGTEPIVLDSLKQHYFIDRDGE 82

  Fly   188 MFRHILNFMRNSRLLIAEDFPDLELLLEEARYYEVEPMIKQLESMRKDRVRNGNYLVAPPTPPAR 252
            :||:||:|:|.|:||:.|||.:..||.|||:||::.||:|:||..::|:...            :
Frog    83 IFRYILSFLRTSKLLLPEDFKEFNLLYEEAKYYQLHPMVKELERWKQDKEHR------------K 135

  Fly   253 HIKTSPRTSASPECNYEVVALHISPDLGERIMLSAERALLDELFPEASQATQSSRSGVSWNQGDW 317
            |.:         .|:..||  .::|||||||.||.|:||::|:|||......:| ....||| |.
Frog   136 HFQ---------PCDCLVV--RVTPDLGERIALSGEKALIEEIFPETGDVMCNS-VNAGWNQ-DP 187

  Fly   318 GQIIRFPLNGYCKLNSVQVLTRLLNAGFTIEASVGG----QQFSEYLLAR 363
            ..:|||||||||:|||||||.|:...||.:.||.||    .|||||:|.|
Frog   188 THVIRFPLNGYCRLNSVQVLERMFQKGFHVAASCGGGVDSSQFSEYVLCR 237

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
twz	NP_001246449.1	BTB_POZ_KCTD1-like	137..230	CDD:349670	62/92 (67%)
kctd15	NP_989239.1	BTB_POZ_KCTD15	29..127	CDD:349696	66/97 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	135	1.000	Domainoid score	I4933
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11450
Inparanoid	1	1.050	233	1.000	Inparanoid score	I3338
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D412532at33208
OrthoFinder	1	1.000	-	-		FOG0002897
OrthoInspector	1	1.000	-	-		otm48821
Panther	1	1.100	-	-	LDO	PTHR14499
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5816
SonicParanoid	1	1.000	-	-		X1912
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.100