DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment twz and Kctd1

DIOPT Version :9

Sequence 1:	NP_001246449.1	Gene:	twz / 37456	FlyBaseID:	FBgn0034636	Length:	367	Species:	Drosophila melanogaster
Sequence 2:	NP_001093986.1	Gene:	Kctd1 / 291772	RGDID:	621566	Length:	861	Species:	Rattus norvegicus

Alignment Length:	364	Identity:	153/364 - (42%)
Similarity:	198/364 - (54%)	Gaps:	45/364 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 PKRKKCDMDRERERDVKALEPRDLSSTGRIYARSD-----IKISSSPT-VSPTISNSSSPTPTPP 81
            ||..:...|.:.|...|......:..:|.|...|.     |:.||.|. ....:|....|.|..|
  Rat   512 PKDSQVGPDVKSEAAPKRALYESVFGSGEICGPSSPKRLCIRPSSEPVDAVVVVSVKHDPLPLLP 576

  Fly    82 ASSSVTPLGLPGAVAAAAAAVGGASSAGASSYL--HGNHKPIT--GIPCVAAASRYTAPVHIDVG 142
            ..:.......|..|:.|..:....|....|..|  .....|:.  |||..|..::..||||||||
  Rat   577 EVNGHRSTNSPTIVSPAIVSPTQDSRPNMSRPLITRSPASPLNNQGIPTPAQLTKSNAPVHIDVG 641

  Fly   143 GTIYTSSLETLTKYPESKLAKLFNGQIPIVLDSLKQHYFIDRDGGMFRHILNFMRNSRLLIAEDF 207
            |.:|||||.||||||||::.:||:|..|||||||||||||||||.|||:||||:|.|:|||.:||
  Rat   642 GHMYTSSLATLTKYPESRIGRLFDGTEPIVLDSLKQHYFIDRDGQMFRYILNFLRTSKLLIPDDF 706

  Fly   208 PDLELLLEEARYYEVEPMIKQLESMRKDRVRNGNYLVAPPTPPARHIKTSPRTSASPECNYEVVA 272
            .|..||.|||:|::::||:.::|..::||                  :|| |.|...||    :.
  Rat   707 KDYTLLYEEAKYFQLQPMLLEMERWKQDR------------------ETS-RFSRPCEC----LV 748

  Fly   273 LHISPDLGERIMLSAERALLDELFPEASQATQSSRSGVSWNQGDWGQIIRFPLNGYCKLNSVQVL 337
            :.::|||||||.||.:::|::|:|||......:| ....||. |...:|||||||||.|||||||
  Rat   749 VRVAPDLGERITLSGDKSLIEEVFPEIGDVMCNS-VNAGWNH-DSTHVIRFPLNGYCHLNSVQVL 811

  Fly   338 TRLLNAGFTIEASVGG----QQFSEYLLAR------RVP 366
            .||...||.|..|.||    .|||||:|.|      |||
  Rat   812 ERLQQRGFEIVGSCGGGVDSSQFSEYVLRRELRRTPRVP 850

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
twz	NP_001246449.1	BTB_POZ_KCTD1-like	137..230	CDD:349670	63/92 (68%)
Kctd1	NP_001093986.1	DNA_BRE_C	279..434	CDD:294145
		BTB	636..731	CDD:197585	64/94 (68%)
		BTB	636..728	CDD:295341	63/91 (69%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350273
Domainoid	1	1.000	136	1.000	Domainoid score	I4799
eggNOG	1	0.900	-	-		E1_KOG2723
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	239	1.000	Inparanoid score	I3277
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D412532at33208
OrthoFinder	1	1.000	-	-		FOG0002897
OrthoInspector	1	1.000	-	-		otm45727
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14499
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1912
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.900