DRSC/TRiP Functional Genomics Resources

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Protein Alignment twz and KCTD1

DIOPT Version :9

Sequence 1:NP_001246449.1 Gene:twz / 37456 FlyBaseID:FBgn0034636 Length:367 Species:Drosophila melanogaster
Sequence 2:NP_001136202.1 Gene:KCTD1 / 284252 HGNCID:18249 Length:865 Species:Homo sapiens


Alignment Length:387 Identity:150/387 - (38%)
Similarity:196/387 - (50%) Gaps:85/387 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 QRSPLTVDSSCPKR----------KKCDMDRERERDVKALEPRDLSSTGRIYARSDIKISSSP-- 64
            |..|.....:.|||          :.|.....:...::..||.|        |...:.:...|  
Human   521 QVGPDVKSEAAPKRALYESVFGSGEICGPTSPKRLCIRPSEPVD--------AVVVVSVKHDPLP 577

  Fly    65 ----------TVSPTISNSSSPTPTPPASSSVTPLGLPGAVAAAAAAVGGASSAGASSYLHGNHK 119
                      |.||||   .||....|...|...:..|....:.|:.:..               
Human   578 LLPEANGHRSTNSPTI---VSPAIVSPTQDSRPNMSRPLITRSPASPLNN--------------- 624

  Fly   120 PITGIPCVAAASRYTAPVHIDVGGTIYTSSLETLTKYPESKLAKLFNGQIPIVLDSLKQHYFIDR 184
              .|||..|..::..|||||||||.:|||||.||||||||::.:||:|..|||||||||||||||
Human   625 --QGIPTPAQLTKSNAPVHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVLDSLKQHYFIDR 687

  Fly   185 DGGMFRHILNFMRNSRLLIAEDFPDLELLLEEARYYEVEPMIKQLESMRKDRVRNGNYLVAPPTP 249
            ||.|||:||||:|.|:|||.:||.|..||.|||:|::::||:.::|..::||             
Human   688 DGQMFRYILNFLRTSKLLIPDDFKDYTLLYEEAKYFQLQPMLLEMERWKQDR------------- 739

  Fly   250 PARHIKTSPRTSASPECNYEVVALHISPDLGERIMLSAERALLDELFPEASQATQSSRSGVSWNQ 314
                  .:.|.|...||    :.:.::|||||||.||.:::|::|:|||......:| ....||.
Human   740 ------ETGRFSRPCEC----LVVRVAPDLGERITLSGDKSLIEEVFPEIGDVMCNS-VNAGWNH 793

  Fly   315 GDWGQIIRFPLNGYCKLNSVQVLTRLLNAGFTIEASVGG----QQFSEYLLAR------RVP 366
             |...:|||||||||.|||||||.||...||.|..|.||    .|||||:|.|      |||
Human   794 -DSTHVIRFPLNGYCHLNSVQVLERLQQRGFEIVGSCGGGVDSSQFSEYVLRRELRRTPRVP 854

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
twzNP_001246449.1 BTB_POZ_KCTD1-like 137..230 CDD:349670 63/92 (68%)
KCTD1NP_001136202.1 DUF3504 284..439 CDD:288835
BTB 640..735 CDD:197585 64/94 (68%)
BTB 640..732 CDD:295341 63/91 (69%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165156341
Domainoid 1 1.000 135 1.000 Domainoid score I4984
eggNOG 1 0.900 - - E1_KOG2723
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 238 1.000 Inparanoid score I3374
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D412532at33208
OrthoFinder 1 1.000 - - FOG0002897
OrthoInspector 1 1.000 - - otm41604
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR14499
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5816
SonicParanoid 1 1.000 - - X1912
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1312.890

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