DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment twz and Kctd8

DIOPT Version :9

Sequence 1:	NP_001246449.1	Gene:	twz / 37456	FlyBaseID:	FBgn0034636	Length:	367	Species:	Drosophila melanogaster
Sequence 2:	NP_780728.3	Gene:	Kctd8 / 243043	MGIID:	2443804	Length:	476	Species:	Mus musculus

Alignment Length:	245	Identity:	66/245 - (26%)
Similarity:	109/245 - (44%)	Gaps:	66/245 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 TPPASSSVTPLGLPGAVAAAAAAVGGASSAGASSYLHGNHKPITGIPCVAAASRYTAPVHIDVGG 143
            |....|::.|:         :..|..:||.||         |:...|...|.|.:...|.::|||
Mouse     6 TGSGGSTILPI---------SEMVSASSSPGA---------PLAAAPGPCAPSPFPEVVELNVGG 52

  Fly   144 TIYTSSLETLTKYPESKLAKLFN-----------GQIPIVLDSLKQHYFIDRDGGMFRHILNFMR 197
            .:|.:...||...|:|.||.:|:           |.:|  .|| :..:||||||.:||::|:::|
Mouse    53 QVYVTKHSTLLSVPDSTLASMFSPSSPRGGARRRGDLP--RDS-RARFFIDRDGFLFRYVLDYLR 114

  Fly   198 NSRLLIAEDFPDLELLLEEARYYEVEPMIKQLESMRKDRVRNGNYLVAPPTPPARHIKTSPRTSA 262
            :.:|.:.|.||:.|.||.||.::::..::|               |::|        |.:.:.|.
Mouse   115 DKQLALPEHFPEKERLLREAEFFQLTDLVK---------------LLSP--------KVTKQNSL 156

  Fly   263 SPECNYEVVALHISPDLGERIMLSAERALLDELFPEASQATQSSRS-GVS 311
            :.||        ...||.:.:...:..|||  |...|:.|...|.: |||
Mouse   157 NDEC--------CQSDLEDNVSQGSSDALL--LRGAAAGAPSGSGAHGVS 196

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
twz	NP_001246449.1	BTB_POZ_KCTD1-like	137..230	CDD:349670	36/103 (35%)
Kctd8	NP_780728.3	BTB	46..145	CDD:197585	36/116 (31%)
		BTB	46..142	CDD:295341	35/98 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	331..412
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846738
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2723
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740