DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment twz and KCTD11

DIOPT Version :9

Sequence 1:	NP_001246449.1	Gene:	twz / 37456	FlyBaseID:	FBgn0034636	Length:	367	Species:	Drosophila melanogaster
Sequence 2:	NP_001350571.1	Gene:	KCTD11 / 147040	HGNCID:	21302	Length:	271	Species:	Homo sapiens

Alignment Length:	169	Identity:	56/169 - (33%)
Similarity:	86/169 - (50%)	Gaps:	31/169 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 PCVAAASRYTAPVHIDVGGTIYTSSLETLTKYPESKLAKLFNGQIPIVLDSLKQ---HYFIDRDG 186
            |..::...:..||.::||||:|:::|||||::|:|.|..:|....|:..:...|   ||||||||
Human     5 PVPSSPPSFGGPVTLNVGGTLYSTTLETLTRFPDSMLGAMFRAGTPMPPNLNSQGGGHYFIDRDG 69

  Fly   187 GMFRHILNFMRNSRLLIAEDFPDLELLLEEARYYEVEPMIKQLESMRKDRVRNGNYLVAPPTPPA 251
            ..|||||||:|..||.:...:.:..||..||.:|::.|:   |:::|:.....|.     |.|.|
Human    70 KAFRHILNFLRLGRLDLPRGYGETALLRAEADFYQIRPL---LDALRELEASQGT-----PAPTA 126

  Fly   252 RHIKTSPRTSASPECNYEVVALHISPDLGERIM-LSAER 289
                               ..||...|:..|:: .||.|
Human   127 -------------------ALLHADVDVSPRLVHFSARR 146

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
twz	NP_001246449.1	BTB_POZ_KCTD1-like	137..230	CDD:349670	41/95 (43%)
KCTD11	NP_001350571.1	BTB	17..109	CDD:321966	41/94 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156340
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2723
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740