Protein Alignment twz and KCTD19

DIOPT Version :9

• Sequence 1: NP_001246449.1
• Gene: twz / 37456
• FlyBaseID: FBgn0034636
• Length: 367
• Species: Drosophila melanogaster
• Sequence 2: NP_001094385.1
• Gene: KCTD19 / 146212
• HGNCID: 24753
• Length: 926
• Species: Homo sapiens
• Alignment Length: 412
• Identity: 85/412 - (20%)
• Similarity: 132/412 - (32%)
• Gaps: 135/412 - (32%)

  Fly    36 RDVKALEPRDLSSTGRIYARSDIKISSSPTVSPTI------SNSSSPTPTPPAS----------S 84
            |..|.|.|.:.|:...:.|  :::|...|.::..:      ....|||...|.|          .
Human   219 RSQKILLPDNFSNIDVLEA--EVEILEIPALTEAVRWYRMNMGGCSPTTCSPLSPGKGARTASLE 281

  Fly    85 SVTP-----LGLPGAVAAAAAAVG----GASSAGASSYLHGN----------------------- 117
            ||.|     |||  .|....:|:|    .::..|:..|:.||
Human   282 SVKPLYTMALGL--LVKYPDSALGQLRIESTLDGSRLYITGNGVLFQHVKNWLGTCRLPLTETIS 344

  Fly   118 ----------HKPITGIPCVAAASRYTAP------------------------VHIDVGGTIYTS 148
                      .:.||..|...|...:..|                        :.:.||...|.:
Human   345 EVYELCAFLDKRDITYEPIKVALKTHLEPRTLAPMDVLNEWTAEITVYSPQQIIKVYVGSHWYAT 409

  Fly   149 SLETLTKYPESKLAKLFNGQIPIVLDSLKQHYFIDRDGGMFRHILNFMRNSRLLIAEDFPDLELL 213
            :|:||.||||     |.:....:...:..|...|..||.||||||||:|..:|.:..:|.:..|.
Human   410 TLQTLLKYPE-----LLSNPQRVYWITYGQTLLIHGDGQMFRHILNFLRLGKLFLPSEFKEWPLF 469

  Fly   214 LEEARYYEVEPMI---------------KQLESMRKDRVRNGNYLVAPPTPPARHIKTSPRTSAS 263
            .:|...|.:..:.               |:.|:.....:|..:.:...|.......:.:..|:|.
Human   470 CQEVEEYHIPSLSEALAQCEAYKSWTQEKESENEEAFSIRRLHVVTEGPGSLVEFSRDTKETTAY 534

  Fly   264 PECNYEVVALHISPDLGERI--------------MLSAE---RALLDELFPEASQA----TQSSR 307
            ...::|        |..:|.              |..||   |.:...|...|.:|    |.|..
Human   535 MPVDFE--------DCSDRTPWNKAKGNLVRSNQMDEAEQYTRPIQVSLCRNAKRAGNPSTYSHC 591

  Fly   308 SGVSWNQGDWGQIIRFPLNGYC 329
            .|:..|.|.||.....|....|
Human   592 RGLCTNPGHWGSHPESPPKKKC 613

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
twz	NP_001246449.1	BTB_POZ_KCTD1-like	137..230	CDD:349670	30/107 (28%)
KCTD19	NP_001094385.1	BTB	18..>72	CDD:321966
		BTB	398..488	CDD:321966	29/94 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	673..751

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156333
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2723
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740