DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment twz and AgaP_AGAP000478

DIOPT Version :9

Sequence 1:	NP_001246449.1	Gene:	twz / 37456	FlyBaseID:	FBgn0034636	Length:	367	Species:	Drosophila melanogaster
Sequence 2:	XP_310614.4	Gene:	AgaP_AGAP000478 / 1271761	VectorBaseID:	AGAP000478	Length:	324	Species:	Anopheles gambiae

Alignment Length:	265	Identity:	73/265 - (27%)
Similarity:	116/265 - (43%)	Gaps:	73/265 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 AASRYTAP---------VHIDVGGTIYTSSLETLT-KYPESKLAKLFNGQIPIVLDSLKQ----- 178
            ||.| |||         |.::|||.|:|::..||| :.|.|.:|::|      ..|.||.
Mosquito    21 AAIR-TAPEPDGRAERWVTLNVGGEIFTTTRLTLTNREPNSMIARMF------AQDQLKPAEQDG 78

  Fly   179 --HYFIDRDGGMFRHILNFMRNSRLLIAEDFPDLELLLEEARYYEVEPMIKQLESMRKDRVRNGN 241
              .|.|||:|..||.||:::|:.| :|.:....|:.:|||||||.::.:.:.::.:.:..|
Mosquito    79 QGAYLIDRNGHYFRPILDYLRHGR-VIYDPHVSLQGILEEARYYGLDGLARLIQEIERADV---- 138

  Fly   242 YLVAPPTPPARHIKTSPRTSASPECNYEVVALHISP------DLGERIMLSAERALLDELFPEAS 300
                 .......|:|...:|.:.|..::  .:|:|.      ||..   ::.:.|.|..
Mosquito   139 -----SLTRLDFIRTLVTSSHTTELRFQ--GVHLSGINLSKLDLRN---INFKYACLSH------ 187

  Fly   301 QATQSSRSGVSWNQGDWGQIIRFPLNGYCKLNSVQV--------------LTR--LLNA---GFT 346
              ...|.:.:||...:..::....|.| .||:||..              |||  |.||   |.|
Mosquito   188 --CNLSYANLSWCCLERAELRCANLEG-AKLHSVMAACADLQGAKLKCCDLTRCSLENANMKGAT 249

  Fly   347 IEASV 351
            :|.||
Mosquito   250 LEGSV 254

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
twz	NP_001246449.1	BTB_POZ_KCTD1-like	137..230	CDD:349670	36/100 (36%)
AgaP_AGAP000478	XP_310614.4	BTB	36..133	CDD:197585	36/103 (35%)
		BTB	37..127	CDD:295341	36/96 (38%)
		Pentapeptide_4	159..235	CDD:290330	15/89 (17%)
		Pentapeptide	160..196	CDD:279183	7/48 (15%)
		Pentapeptide	183..215	CDD:279183	7/40 (18%)
		Pentapeptide	223..257	CDD:279183	11/32 (34%)
		Pentapeptide_4	234..310	CDD:290330	11/21 (52%)
		Pentapeptide	268..307	CDD:279183
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910