DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment twz and kctd1

DIOPT Version :9

Sequence 1:	NP_001246449.1	Gene:	twz / 37456	FlyBaseID:	FBgn0034636	Length:	367	Species:	Drosophila melanogaster
Sequence 2:	XP_012820753.2	Gene:	kctd1 / 100486970	XenbaseID:	XB-GENE-6076050	Length:	840	Species:	Xenopus tropicalis

Alignment Length:	346	Identity:	146/346 - (42%)
Similarity:	194/346 - (56%)	Gaps:	59/346 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 SSTGRIYARSDIKISSSP---TVSP--------TISNSSSPTPTPPASSSVTPLGLPGAVAAAAA 100
            :|...|||..|:....||   .:.|        .:|..|.|.|:.|.::.       ..|.||:.
Frog   509 NSAHSIYASGDMGSPPSPKRLCIRPADPSDCVHVVSVKSDPQPSCPETNG-------HMVLAASP 566

  Fly   101 AVGGASSAGASSYLHGN-HKPI-----------TGIPCVAAASRYTAPVHIDVGGTIYTSSLETL 153
            ||...|..........| .:|:           .|||..|..::..|||||||||.:|||||.||
Frog   567 AVTSPSVMSPVQDTRPNMSRPLITRSPASPLSNQGIPTPAQLTKSNAPVHIDVGGHMYTSSLATL 631

  Fly   154 TKYPESKLAKLFNGQIPIVLDSLKQHYFIDRDGGMFRHILNFMRNSRLLIAEDFPDLELLLEEAR 218
            ||||:|::.:||:|..|||||||||||||||||.|||:||||:|.|:|||::||.|..||.|||:
Frog   632 TKYPDSRIGRLFDGTEPIVLDSLKQHYFIDRDGQMFRYILNFLRTSKLLISDDFKDYSLLYEEAK 696

  Fly   219 YYEVEPMIKQLESMRKDRVRNGNYLVAPPTPPARHIKTSPRTSASPECNYEVVALHISPDLGERI 283
            |::::||:.:||..::|                   |.:.|.|...||    :.:.::|||||||
Frog   697 YFQLQPMLLELERWKQD-------------------KEAGRFSRPCEC----LVVRVAPDLGERI 738

  Fly   284 MLSAERALLDELFPEASQATQSSRSGVSWNQGDWGQIIRFPLNGYCKLNSVQVLTRLLNAGFTIE 348
            .||.:::|::|:|||......:| ....||. |...:|||||||||.|||||||.||.:.||.|.
Frog   739 TLSGDKSLIEEVFPEIGDVMCNS-VNAGWNH-DSTHVIRFPLNGYCHLNSVQVLERLQHRGFEIV 801

  Fly   349 ASVGG----QQFSEYLLARRV 365
            .|.||    .|||||:|.|.:
Frog   802 GSCGGGVDSSQFSEYVLRREL 822

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
twz	NP_001246449.1	BTB_POZ_KCTD1-like	137..230	CDD:349670	62/92 (67%)
kctd1	XP_012820753.2	DNA_BRE_C	270..435	CDD:412227
kctd1	XP_012820753.2	BTB_POZ_KCTD1	611..715	CDD:349695	67/122 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	135	1.000	Domainoid score	I4933
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D412532at33208
OrthoFinder	1	1.000	-	-		FOG0002897
OrthoInspector	1	1.000	-	-		otm48821
Panther	1	1.100	-	-	O	PTHR14499
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1912
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.020