DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Egfr and Tek

DIOPT Version :10

Sequence 1:NP_476759.1 Gene:Egfr / 37455 FlyBaseID:FBgn0003731 Length:1426 Species:Drosophila melanogaster
Sequence 2:NP_001099207.1 Gene:Tek / 89804 RGDID:620980 Length:1120 Species:Rattus norvegicus


Alignment Length:1269 Identity:270/1269 - (21%)
Similarity:435/1269 - (34%) Gaps:402/1269 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   133 DGNLELT-----WLPNENL----DLSFLDNIR----EVTGYILISHVDV-----KKVVFPKLQI- 178
            |....||     |.|:|.:    |...|.|..    |||       .||     ||||:.:.:. 
  Rat    37 DAETSLTCIASGWHPHEPITIGRDFEALMNQHQDPLEVT-------QDVTREWAKKVVWKREKAS 94

  Fly   179 -----------IRGRTLFSLSVEEEKYALFVTYSKMYTLEIPDLRDVLNGQVGFHNNYNLCHMRT 232
                       :||:.:...:::..:.|.|:..:...|::..|             |.|      
  Rat    95 KINGAYFCEGRVRGQAIRIRTMKMRQQASFLPATLTMTVDRGD-------------NVN------ 140

  Fly   233 IQWSEIVSNGTDA--YYNYDF--TAPERECPKCHE-SCTHGCWGEGPKNCQKFSKLTCSPQCAG- 291
            |.:.:::....||  |.|..|  :.|..|.|...| ...|                 ..||.|| 
  Rat   141 ISFKKVLIKEEDAVIYKNGSFIHSVPRHEVPDILEVHLPH-----------------AQPQDAGV 188

  Fly   292 --GRCYGPKPRECCHLF-----------CAGGCTGP-TQKDCIACKNFFDEGVCKEE-----CPP 337
              .|..|.      :||           |.....|| ..:.|..|||   .|||.|:     |||
  Rat   189 YSARYIGG------NLFTSAFTRLIVRRCEAQKWGPDCNRPCTTCKN---NGVCHEDTGECICPP 244

  Fly   338 MRKYNPTTYVLETNPEGKYAYGATCVKECPG--------HLLRDNGACVRSCPQDKMDKGGECVP 394
              .:...|......|   :.:|.||.:.|.|        ..|.|...|  ||.     .|...:.
  Rat   245 --GFMGRTCEKACEP---HTFGRTCKERCSGSEGCKSYVFCLPDPYGC--SCA-----TGWRGLQ 297

  Fly   395 CNGPCPKTCPGVTV---LHAGN---IDSFRNCTVIDGNIRILDQTFSGFQ-DVYANYTMGPRYIP 452
            ||..||....|...   .|..|   .|.|:.|        :..|.:.|.| :......|.|:...
  Rat   298 CNEACPYGHYGPDCKLRCHCTNEEMCDRFQGC--------LCSQGWQGLQCEKEGRPRMTPQIED 354

  Fly   453 LDPERLEVFSTVKEITGYLNIEGTHPQFRNLSYFRNLETIHGRQLMESMFAALAIVKSSLYSLEM 517
            | |:.:||                     |...|..:....|..|..|  ..:.:||.....|:.
  Rat   355 L-PDHIEV---------------------NSGKFNPICKASGWPLPTS--EEMTLVKPDGTVLQP 395

  Fly   518 RNLKQISSGSVVI-QHNRDLCYVSNIRWPAIQKEPEQKVWV-NENLRADLCEKNGTICSDQCNED 580
            .:.......||.| ..||.|             .|:..||| :.|..|.:.||...|......|.
  Rat   396 NDFNHTDHFSVAIFTVNRIL-------------PPDSGVWVCSVNTVAGMVEKPFNISVKVLPEP 447

  Fly   581 GCWGAGTDQCLTCKNFNFNGTCIADCGY---------------------------ISNAYKF--- 615
                      |...|       :.|.|:                           ::.|:|:   
  Rat   448 ----------LHAPN-------VIDTGHNFAIINISSEPYFGDGPIKSKKLFYKPVNQAWKYIQV 495

  Fly   616 DNRTCKICHPECRTCNGAGADHCQECVH-VRDGQHCVSECPKNKYNDRGVCRECHATCDGCTGPK 679
            .|....:.:.|.||      |: :.||. ||.|:                      ..:|..||.
  Rat   496 MNEIVTLNYLEPRT------DY-ELCVQLVRPGE----------------------GGEGHPGPV 531

  Fly   680 ---DTIGIGACTTCNLAIINNDATVKRCLLKD--DKCPDGYF-----WEYVHPQEQGSLKPLAGR 734
               .|..||......|:::....|......:.  ....|.::     |......:|.::| :.|.
  Rat   532 RRFTTASIGLPPPRGLSLLPKSQTALNLTWQPIFTSSEDEFYVEVERWSQQTRSDQQNIK-VPGN 595

  Fly   735 AVCRKCHPLCELCTNYGYHEQVCSKCTHYKRREQCETECPADHYTDEEQR-----ECFQCHPECN 794
            ..       ..|..|....||       |..|.:..|:...:  ..||.|     :.....||  
  Rat   596 LT-------SVLLNNLLPREQ-------YSVRARVNTKAQGE--WSEELRAWTLSDILPPQPE-- 642

  Fly   795 GCTGPGADDCKSCRNFKLFDANETGPYVNSTMFNCTSKCPL----------EMRHVN-------- 841
                          |.|:.:..:....|:.|:.:..|...:          |.:|::        
  Rat   643 --------------NIKITNITDYTALVSWTIVDGYSISSIIIRYKVQGKNEDQHIDVKIKNATI 693

  Fly   842 --YQYTAIGPYC-------------AASPPRSSKI---TANLDVN-----MIFIITGAVLVPTIC 883
              ||...:.|..             :::|..|.:|   .|..|:.     :|.|:..|.:.   |
  Rat   694 TQYQLKGLEPETTYHVDIFAENNIGSSNPAFSQEIRTLPAPKDLGGGKMLLIAILGSAGMT---C 755

  Fly   884 ILCVVTYICRQKQKAKKETVKMTMALSGCEDSEPLRPSNIGANLCKLRIVKD------------A 936
            |..::.::...:.|......:|..|.....: ||....|.| .|...|..|:            .
  Rat   756 ITVLLAFLIMLQLKRANVQRRMAQAFQNVRE-EPAVQFNSG-TLALNRKAKNNPDPTIYPVLDWN 818

  Fly   937 ELRKGGVLGMGAFGRVYKGVWVPEGENVKIPVAIKELLKSTGAESSEEFLREAYIMASV-EHVNL 1000
            :::...|:|.|.||:|.|.....:|  :::..|||.:.:....:...:|..|..::..: .|.|:
  Rat   819 DIKFQDVIGEGNFGQVLKARIKKDG--LRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNI 881

  Fly  1001 LKLLAVC-MSSQMMLITQLMPLGCLLDYVRNNR---------------DKIGSKALLNWSTQIAK 1049
            :.||..| ....:.|..:..|.|.|||::|.:|               ..:.|:.||:::..:|:
  Rat   882 INLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVAR 946

  Fly  1050 GMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAGGKMPIKWLALECIRN 1114
            ||.||.:|:.:||||||||:||....:.||.||||::   ......|...|::|::|:|:|.:..
  Rat   947 GMDYLSQKQFIHRDLAARNILVGENYIAKIADFGLSR---GQEVYVKKTMGRLPVRWMAIESLNY 1008

  Fly  1115 RVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHL 1179
            .|:|:.||||::||.:||:::.|..|:..:...::.:.:..|.:||:|..|..::|..:..||..
  Rat  1009 SVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWRE 1073

  Fly  1180 DAAMRPTFKQL----------------TTVFAEF 1197
            ....||:|.|:                ||::.:|
  Rat  1074 KPYERPSFAQILVSLNRMLEERKTYVNTTLYEKF 1107

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EgfrNP_476759.1 Recep_L_domain 128..239 CDD:460032 27/135 (20%)
Furin-like 253..401 CDD:395614 43/176 (24%)
Recep_L_domain 419..547 CDD:460032 24/129 (19%)
GF_recep_IV 572..684 CDD:464344 22/145 (15%)
FU 662..716 CDD:214589 9/58 (16%)
GF_recep_IV 740..>834 CDD:464344 17/98 (17%)
PTKc_EGFR_like 930..1208 CDD:270648 86/313 (27%)
TekNP_001099207.1 Ig_Tie2_1 24..118 CDD:463089 20/87 (23%)
EGF_Lam 230..275 CDD:238012 14/49 (29%)
IgI_Tie2 348..439 CDD:409556 28/127 (22%)
Ig strand A 348..352 CDD:409556 2/3 (67%)
Ig strand A' 358..362 CDD:409556 2/24 (8%)
Ig strand B 365..374 CDD:409556 1/8 (13%)
Ig strand C 382..387 CDD:409556 0/4 (0%)
Ig strand C' 391..393 CDD:409556 0/1 (0%)
Ig strand D 397..401 CDD:409556 0/3 (0%)
Ig strand E 404..412 CDD:409556 3/7 (43%)
Ig strand F 420..428 CDD:409556 3/7 (43%)
Ig strand G 431..439 CDD:409556 2/7 (29%)
fn3 445..518 CDD:394996 14/96 (15%)
fn3 542..625 CDD:394996 14/99 (14%)
FN3 638..730 CDD:238020 15/107 (14%)
PTKc_Tie2 812..1114 CDD:133219 84/301 (28%)

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