DRSC/TRiP Functional Genomics Resources

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Protein Alignment Egfr and ntrk3b

DIOPT Version :10

Sequence 1:NP_476759.1 Gene:Egfr / 37455 FlyBaseID:FBgn0003731 Length:1426 Species:Drosophila melanogaster
Sequence 2:XP_002662799.4 Gene:ntrk3b / 798577 ZFINID:ZDB-GENE-010126-4 Length:818 Species:Danio rerio


Alignment Length:933 Identity:212/933 - (22%)
Similarity:352/933 - (37%) Gaps:269/933 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   399 CPKTCPGVTVLHAGNIDSFRNCTVIDGNIRILDQTFSGFQDVYANYTMGPRYIPLDPERLEVFST 463
            ||.||               :|:.               .::|.|.:....:.||    |.:..:
Zfish    33 CPPTC---------------SCSP---------------TEIYCNKSDVGNFFPL----LALQES 63

  Fly   464 VKEITGYLNIEGTHPQFRNLSYFRNLETIH-----GRQLMESMFAALAIVKSSLYSLEMR----- 518
            ....:...:||         ..|||:.:||     |.|::..       |...||:...|     
Zfish    64 AGNGSNNNDIE---------ELFRNITSIHIENWTGLQILRD-------VDMELYTGLQRLTIIN 112

  Fly   519 -NLKQISSGSVVIQHNRDLCYVSNIRWPAIQKEPEQKVW-VNENLRADLCEKNGTICSDQCNEDG 581
             ||:||...:  ...|..|.|::..|.|.....     | :.::|:.......|.:.  .|   |
Zfish   113 CNLRQIQPRA--FSRNPHLRYINLSRNPLASLS-----WQLFQHLQLVELRLEGVVF--DC---G 165

  Fly   582 C-------W------GAGTDQCLTCKN----FNFNGTCIADCGYISNAYKFDNRTCKICHPECR- 628
            |       |      |..|.| |.||:    .:.....||.|         |.:...:.|.... 
Zfish   166 CKIRWIQLWRLRGEAGLHTQQ-LYCKDGASKISLRSMSIAHC---------DLQDISVAHSNLTV 220

  Fly   629 --------TCNGAGADHCQECVHVRDGQHCVSECPKNKYNDRGVCRECHATCDGCTGPKDTIGIG 685
                    :|||:|                 |..|:..:..:|:    |:    ....:.|:.:.
Zfish   221 LEGGNVTLSCNGSG-----------------SPVPEVDWAVKGL----HS----INTHQSTVYLP 260

  Fly   686 ACTTCNLAIINNDATVKRCLLKDDKCPDGYFWEYVHPQEQG------SLKPLAGRAVCR-----K 739
            ...:.||.::|        :.:||   :|:....:.....|      .|..|....:.:     :
Zfish   261 NTHSINLTLVN--------VSRDD---NGFVLTCISENVVGMNNVSLQLSVLFPPVILKLDEPER 314

  Fly   740 CHPLCELCTNYGY-HEQVCSKCTH--YKRREQCETE---CPADHYTDEEQRECFQCHPECNGC-- 796
            .|..|...|..|: |..:     |  ||.||..::|   ...|:|.|           ...||  
Zfish   315 RHHTCIEFTVRGFPHPTL-----HWFYKGREILQSEYIRMEMDYYKD-----------YLEGCLT 363

  Fly   797 -TGPGADDCKSCRNFKLFDANETGPYVNSTMFNCTSKCPLEMRHVNYQYTAIGPYCAASPPRSSK 860
             ..|...|   ..|:.|...|..|. |:.|:|......|........:||         ||...:
Zfish   364 FENPTHYD---NGNYTLVATNSLGS-VSKTVFGHFLDPPFMEDDGIMEYT---------PPPEDE 415

  Fly   861 ITANLDVNMIFIITGAVLVPTICILCVVTYICRQK-QKAKKETVKMTMA-LSGCEDS-EPLR--- 919
            .....|...:.|..|  |....|:..:|.::...| .:..|..:|..:| :||.||| .||.   
Zfish   416 GKRPEDSFGMSIAVG--LAGFGCVFLIVIFVLINKYSRRNKFGIKGPVAVISGEEDSASPLHHVN 478

  Fly   920 ------------PSNIGANLCKLRIVKDAELRKGG----------------------VLGMGAFG 950
                        |..:...:.::.::::.:..:.|                      .||.||||
Zfish   479 HGIVTPCSLDAGPDAVVIGMSRIPVIENPQYFRHGHNCNKPTTYVQHIKRRDIVLKRELGEGAFG 543

  Fly   951 RVYKGVWVPEGENV-----KIPVAIKELLKSTGAESSEEFLREAYIMASVEHVNLLKLLAVCMSS 1010
            :|:    :.|..|:     |:.||:| .||.....:.::|.|||.::.:::|.:::|...||:..
Zfish   544 KVF----LAECYNLSPTKDKMLVAVK-TLKDPTLTARKDFQREAELLTNLQHEHIVKFYGVCVDG 603

  Fly  1011 Q-MMLITQLMPLGCLLDYVR---------------NNRDKIGSKALLNWSTQIAKGMSYLEEKRL 1059
            . ::::.:.|..|.|..::|               .:..::|...:|:.:||||.||.||..:..
Zfish   604 DPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPMQSNGELGLSQMLHIATQIAAGMVYLSSQHF 668

  Fly  1060 VHRDLAARNVLVQTPSLVKITDFGLAK-LLSSDSNEYKAAGG--KMPIKWLALECIRNRVFTSKS 1121
            ||||||.||.||....||||.|||::: :.|||   |...||  .:||:|:..|.|..|.|:::|
Zfish   669 VHRDLATRNCLVGNGLLVKIGDFGMSRDIYSSD---YYRVGGHTMLPIRWMPPESIMYRKFSTES 730

  Fly  1122 DVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPT 1186
            |||:|||.:||:.|:|::|..::...::.:.|..|..|::|.:|..::|..:|.||..:...|..
Zfish   731 DVWSFGVIMWEIFTYGKQPWFHLSNNEVIECITQGRVLDRPRLCPKEVYDLMLGCWQREPQQRLN 795

  Fly  1187 FKQLTTVFAEFARDPGRYLAIPG 1209
            .|.:..|.....:....||.|.|
Zfish   796 IKDIQKVLYALGKATPVYLDILG 818

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EgfrNP_476759.1 Recep_L_domain 128..239 CDD:460032
Furin-like 253..401 CDD:395614 1/1 (100%)
Recep_L_domain 419..547 CDD:460032 28/138 (20%)
GF_recep_IV 572..684 CDD:464344 24/137 (18%)
FU 662..716 CDD:214589 9/53 (17%)
GF_recep_IV 740..>834 CDD:464344 25/102 (25%)
PTKc_EGFR_like 930..1208 CDD:270648 94/323 (29%)
ntrk3bXP_002662799.4 LRR_8 103..159 CDD:404697 12/62 (19%)
leucine-rich repeat 105..128 CDD:275378 6/24 (25%)
leucine-rich repeat 129..151 CDD:275378 5/26 (19%)
LRRCT_2 164..207 CDD:465313 13/55 (24%)
ig 213..298 CDD:395002 17/120 (14%)
Ig strand B 226..230 CDD:409405 0/3 (0%)
Ig strand C 239..249 CDD:409405 1/13 (8%)
Ig strand E 265..269 CDD:409405 2/3 (67%)
Ig strand F 279..285 CDD:409405 0/5 (0%)
Ig strand G 293..296 CDD:409405 0/2 (0%)
IgI_TrKABC_d5 303..395 CDD:409360 25/111 (23%)
Ig strand A 304..310 CDD:409360 0/5 (0%)
Ig strand A' 312..315 CDD:409360 0/2 (0%)
Ig strand B 318..326 CDD:409360 2/7 (29%)
Ig strand C 329..336 CDD:409360 2/11 (18%)
Ig strand C' 339..342 CDD:409360 2/2 (100%)
Ig strand D 347..353 CDD:409360 0/5 (0%)
Ig strand E 357..365 CDD:409360 2/7 (29%)
Ig strand F 373..381 CDD:409360 2/7 (29%)
Ig strand G 384..392 CDD:409360 3/8 (38%)
PTKc_TrkC 525..811 CDD:270676 91/293 (31%)
Blue background indicates that the domain is not in the aligned region.

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