DRSC/TRiP Functional Genomics Resources

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Protein Alignment Egfr and tyro3

DIOPT Version :10

Sequence 1:NP_476759.1 Gene:Egfr / 37455 FlyBaseID:FBgn0003731 Length:1426 Species:Drosophila melanogaster
Sequence 2:XP_012824144.1 Gene:tyro3 / 780188 XenbaseID:XB-GENE-922144 Length:906 Species:Xenopus tropicalis


Alignment Length:1082 Identity:236/1082 - (21%)
Similarity:363/1082 - (33%) Gaps:364/1082 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   397 GPCPKTCPG------VTVLHAGNIDSFR---------NCTVIDGNIRILDQTFSGFQDVYANY-- 444
            ||     ||      :..|...::|..:         |.||..|:...|:.:..|.::....:  
 Frog     5 GP-----PGLIAGLLLAALSLSSVDGTKALGFVGHGYNMTVSQGHEAKLNCSLQGMEEPEIQWLK 64

  Fly   445 ------TMGPRYIPLDPERLEVFSTVKEI----TGYLNIEGTHPQFRNLS-----------YFRN 488
                  :....|||:|.:....|.::|.:    .|....|..|...:::|           ||  
 Frog    65 DGVPVQSADQMYIPVDEDHWISFLSLKNVERPDAGRYWCEAEHSGRKSVSDAIWVMVEGVPYF-- 127

  Fly   489 LETIHGRQL----------------------------------MESMFAAL---AIVKSSLYSLE 516
              |:..:.|                                  .||..:.|   .|.:.:.:|.|
 Frog   128 --TLEPKDLSVTPNSPFNMTCAAVGPPEPLVIFWWVGDSPLGKSESSPSVLQIPGIRERTAFSCE 190

  Fly   517 MRNLKQISSGSVVIQHNRDLCYVSNIRWPAIQKEPEQKVWVNENLRADLCEKNGTICSDQCNEDG 581
            ..|.|.:||....|...:.|.|            |...|.:::     :.....|:         
 Frog   191 AHNAKGVSSSRTAIVEVKGLPY------------PPFNVTISK-----VTGSTATV--------- 229

  Fly   582 CWGAGTDQCLTCKNFNFNGTCIADCGYISNAYKFDNRTCKICHPECRTCNGAGADHCQECVHVRD 646
            .|..|           ||...:.             ::|.|.....:|...|..          .
 Frog   230 TWSPG-----------FNSFSLI-------------KSCTIQFRGSQTAGSASP----------K 260

  Fly   647 GQHCVSECPKNKYNDRGVCREC----------------------HATCDGCTGPKDTIGIGACTT 689
            |...|.|.|.:|.......||.                      |:....||..     :||...
 Frog   261 GPKVVGEGPGSKVQSLHGNREMYSRLTSVPPFAVVLDDLQPLTNHSVRVQCTNE-----MGASPF 320

  Fly   690 CNLAIINNDATVKR-------------CLLKDDKCPDGYFWEYVHPQEQGSLKPLAGRAVCRKCH 741
            ......|....|.:             |||.|        ||.|.|.::                
 Frog   321 SEWITFNTKEKVPQLIPQNVHMTKTDSCLLLD--------WEDVDPDKE---------------- 361

  Fly   742 PLCELCTNYGYHEQVCSKCTHYKRREQCETECPADHYTDEEQRECFQCHPE-----------CNG 795
                     ||:      ...:|.:.:.|.....:.:..|.|....:.:||           ..|
 Frog   362 ---------GYN------ILGFKVQWEQENTTQGELFVQENQANLTKWNPEKDLTIRICIANAAG 411

  Fly   796 CTGPGADDCKSCRNFKLFDANETGPYVNSTMFNCTSKCPLEMRHVNYQYTAIGPYCAASPPRSSK 860
            | ||.::       |.|..:.|...               :.||         |:...|      
 Frog   412 C-GPWSE-------FLLAGSKEEAG---------------KQRH---------PHTRMS------ 438

  Fly   861 ITANLDVNMIF-IITGAVLVPTICILCVVTYICRQKQKAKKET----------------VKMTMA 908
                 .|.|:. |:|..|.|..:.::.:        :|.:|||                ::.|.|
 Frog   439 -----WVPMVLGILTALVTVVAMTLIFL--------RKGRKETRFGNMLGSMLGRGGPVIQFTAA 490

  Fly   909 LS----GCEDSEPLRPSNIGAN---LCKLR--IVKDAELRKGGVLGMGAFGRVYKGVWVPEGENV 964
            .|    |.|..|....| ||.:   ..||:  :::..:...|..||.|.||.|.:.....|.:.:
 Frog   491 RSFNRRGPEVMEATLDS-IGISDELKSKLKDVLIQQQQFTLGRTLGKGEFGSVREAQLKMEDDTM 554

  Fly   965 KIPVAIKELLKSTGAESS-EEFLREAYIMASVEHVNLLKLLAVCMSSQM-------MLITQLMPL 1021
            : .||:|.|.......|. |||||||..|...:|.|:.||:.|.:.|:.       |:|...|..
 Frog   555 Q-KVAVKMLKAEIFCSSDIEEFLREAAFMKEFDHPNVCKLIGVSLRSRTKGRLPVPMVILPFMKH 618

  Fly  1022 GCLLDYVRNNRDKIGS-------KALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKI 1079
            |.|..::..:|  ||.       :.|:.:...|..||.||..|..:|||||.||.::.....|.:
 Frog   619 GDLHTFLLMSR--IGEEPIALPIQTLVRFMIDICSGMEYLSSKNFIHRDLATRNCMLNEDMTVCV 681

  Fly  1080 TDFGLAKLLSSDSNEYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENI 1144
            .||||:|.:.|.....:....|:|:||||||.:.:.|:|..|||||||||:||::|.||.|:..:
 Frog   682 ADFGLSKKIYSGDYYRQGCASKLPVKWLALESLADNVYTVHSDVWAFGVTLWEIVTRGQTPYAGV 746

  Fly  1145 PAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARDPGRYLAIPG 1209
            ...:|...:..|.:|:||..|..::|..:..||..:...||:|..|..          |..||.|
 Frog   747 ENSEIYSYLTAGNRLKQPPDCLDELYEMMCQCWITEPKRRPSFVDLKR----------RLEAIWG 801

  Fly  1210 DKFTRLPAYTSQDEKDLIRKLAPTTDGSEAIA-------EPDDYLQPKAAPGPSHRTDCTDEIPK 1267
                || :..|.....|...|..|...:.|::       :.:||     ..||| :|..|..|..
 Frog   802 ----RL-SILSASHDQLYVNLGETCGAAAAVSGLHSAFCKEEDY-----CAGPS-QTCGTSAITS 855

  Fly  1268 LNRYCKDPSNKNSSTGDDETDSSAREVGVGNLRLDLPVDEDD 1309
            ..||..:|......   :|..|||:.   |..|..|..:|::
 Frog   856 DYRYIVNPGCLREG---NEWSSSAQN---GEARGLLHEEEEE 891

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EgfrNP_476759.1 Recep_L_domain 128..239 CDD:460032
Furin-like 253..401 CDD:395614 2/3 (67%)
Recep_L_domain 419..547 CDD:460032 33/187 (18%)
GF_recep_IV 572..684 CDD:464344 18/133 (14%)
FU 662..716 CDD:214589 13/88 (15%)
GF_recep_IV 740..>834 CDD:464344 15/104 (14%)
PTKc_EGFR_like 930..1208 CDD:270648 97/294 (33%)
tyro3XP_012824144.1 Ig 38..122 CDD:472250 15/83 (18%)
Ig strand B 46..50 CDD:409353 1/3 (33%)
Ig strand C 59..63 CDD:409353 0/3 (0%)
Ig strand E 86..90 CDD:409353 1/3 (33%)
Ig strand F 100..105 CDD:409353 0/4 (0%)
Ig strand G 114..117 CDD:409353 1/2 (50%)
IgI_2_Axl_Tyro3_like 126..206 CDD:409407 15/83 (18%)
Ig strand A 126..129 CDD:409407 2/6 (33%)
Ig strand A' 132..136 CDD:409407 1/3 (33%)
Ig strand B 140..149 CDD:409407 0/8 (0%)
Ig strand C 154..161 CDD:409407 0/6 (0%)
Ig strand C' 163..166 CDD:409407 0/2 (0%)
Ig strand E 170..181 CDD:409407 3/10 (30%)
Ig strand F 184..193 CDD:409407 2/8 (25%)
Ig strand G 197..206 CDD:409407 3/8 (38%)
FN3 211..328 CDD:238020 24/181 (13%)
fn3 337..416 CDD:394996 20/118 (17%)
PTKc_Tyro3 518..801 CDD:270659 98/295 (33%)
Blue background indicates that the domain is not in the aligned region.

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