Protein Alignment Egfr and TYRO3

DIOPT Version :10

• Sequence 1: NP_476759.1
• Gene: Egfr / 37455
• FlyBaseID: FBgn0003731
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: NP_006284.2
• Gene: TYRO3 / 7301
• HGNCID: 12446
• Length: 890
• Species: Homo sapiens
• Alignment Length: 965
• Identity: 218/965 - (22%)
• Similarity: 324/965 - (33%)
• Gaps: 315/965 - (32%)

  Fly   420 CTVIDGNIRILDQ----TFSGFQDVYANYTMGPRYIPLDPERLEVFSTVKEITGYLNIEGTHPQF 480
            |.|.||....:.|    |..|    ...:|:.|:.:.:.|.  ..|....|..|       .|:.
Human   117 CQVEDGGETEISQPVWLTVEG----VPFFTVEPKDLAVPPN--APFQLSCEAVG-------PPEP 168

  Fly   481 RNLSYFRNLETIHGRQLMESMFAALAIVKSSLYSLEMRNLKQISSGSVVIQHNRDLCYVSNIRWP 545
            ..:.::|....|.|.....|:.....:.:|:::|.|..|||.::|......|.:.|        |
Human   169 VTIVWWRGTTKIGGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQAL--------P 225

  Fly   546 AIQKEPEQKVWVNENLRADLCEKNGTICS-DQCNEDGCWGAGTD-----QCLTCKNFNFNG---- 600
            |                   ...|.|:.. ...|....|..|.|     |..|.:.....|
Human   226 A-------------------APFNITVTKLSSSNASVAWMPGADGRALLQSCTVQVTQAPGGWEV 271

  Fly   601 ----------TCIADCGYISNAYKFDNRTCKICHPECRTCNGAGADHCQECVHVRDGQHCVSECP 655
                      ||:                                        :||      ..|
Human   272 LAVVVPVPPFTCL----------------------------------------LRD------LVP 290

  Fly   656 KNKYNDRGVCRECHATCDGCTGPK--------DTIGIG-ACTTCNLAIINNDATVKRCLLKDDKC 711
            ...|:.|       ..|....||.        .|.|:. |....||..|..|:.:   :|:
Human   291 ATNYSLR-------VRCANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGL---ILE---- 341

  Fly   712 PDGYFWEYVHPQEQGSLKPLAGRAVCRKCHPLCELCTNYGYHEQVCSKCTHYKRREQCETECPAD 776
                 ||.|.|:     .||.|        ||
Human   342 -----WEEVIPE-----APLEG--------PL--------------------------------- 355

  Fly   777 HYTDEEQRECFQCHPECNGCTGPGADDCKSCRNFKLFDANETGPY----VNSTMFNCTSKCP--- 834
                                 ||          :||....:.|..    |..|..|.|...|
Human   356 ---------------------GP----------YKLSWVQDNGTQDELTVEGTRANLTGWDPQKD 389

  Fly   835 LEMRHVNYQYTAIGPYC------------AASPPRSSKITANLDVNMIFIITGAVLVPTICILCV 887
            |.:|.........||:.            ...||.|.  |:.:.| ::.::|..|....:.::.:
Human   390 LIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQGPPHSR--TSWVPV-VLGVLTALVTAAALALILL 451

  Fly   888 VTYICRQKQKAKKETVKMTMAL-SGCEDSEPL------------RPSNIGANLCKLRI------- 932
                    :|.:||| :...|. |.....||.            ||..|.|.|..|.|
Human   452 --------RKRRKET-RFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEK 507

  Fly   933 -----VKDAELRKGGVLGMGAFGRVYKGVWVPE-GENVKIPVAIKELLKSTGAESS--EEFLREA 989
                 :.:.:...|.:||.|.||.|.:.....| |..||:.|   ::||:....||  |||||||
Human   508 LEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAV---KMLKADIIASSDIEEFLREA 569

  Fly   990 YIMASVEHVNLLKLLAVCMSSQM-------MLITQLMPLGCLLDYVRNNRDKIGS-------KAL 1040
            ..|...:|.::.||:.|.:.|:.       |:|...|..|.|..::..:|  ||.       :.|
Human   570 ACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASR--IGENPFNLPLQTL 632

  Fly  1041 LNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAGGKMPIK 1105
            :.:...||.||.||..:..:||||||||.::.....|.:.||||::.:.|.....:....|:|:|
Human   633 IRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVK 697

  Fly  1106 WLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIY 1170
            |||||.:.:.::|.:|||||||||:||::|.||.|:..|...:|.:.:..|.:|:||..|..|:|
Human   698 WLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVY 762

  Fly  1171 CTLLSCWHLDAAMRPTF----KQLTTVFAEFARDPGRYLAIPGDKFTRLPAYTSQDEKDLIRKLA 1231
            ..:..||..|...||:|    .:|..:..:.:     .|:...|     |.|.     ::.|...
Human   763 DLMYQCWSADPKQRPSFTCLRMELENILGQLS-----VLSASQD-----PLYI-----NIERAEE 812

  Fly  1232 PTTDGSEAIAEPDDYLQPKAAPGPSHRTDCTDEIPKLNRYCKDPSNKNSSTGDDE 1286
            ||..||..:...|   ||.:..|...........|...||...|.......|..|
Human   813 PTAGGSLELPGRD---QPYSGAGDGSGMGAVGGTPSDCRYILTPGGLAEQPGQAE 864

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Egfr	NP_476759.1	Recep_L_domain	128..239	CDD:460032
		Furin-like	253..401	CDD:395614
		Recep_L_domain	419..547	CDD:460032	28/130 (22%)
		GF_recep_IV	572..684	CDD:464344	18/139 (13%)
		FU	662..716	CDD:214589	12/62 (19%)
		GF_recep_IV	740..>834	CDD:464344	11/97 (11%)
		PTKc_EGFR_like	930..1208	CDD:270648	101/310 (33%)
TYRO3	NP_006284.2	Ig1_Tyro3_like	50..136	CDD:409553	6/18 (33%)
		Ig strand A	50..55	CDD:409553
		Ig strand B	58..67	CDD:409553
		Ig strand C	73..78	CDD:409553
		Ig strand C'	81..83	CDD:409553
		Ig strand D	87..92	CDD:409553
		Ig strand E	97..104	CDD:409553
		Ig strand F	113..119	CDD:409553	1/1 (100%)
		Ig strand G	125..136	CDD:409553	2/10 (20%)
		IgI_2_Axl_Tyro3_like	140..220	CDD:409407	18/88 (20%)
		Ig strand A	140..143	CDD:409407	0/2 (0%)
		Ig strand A'	146..150	CDD:409407	0/3 (0%)
		Ig strand B	154..163	CDD:409407	2/8 (25%)
		Ig strand C	168..175	CDD:409407	0/6 (0%)
		Ig strand C'	177..180	CDD:409407	0/2 (0%)
		Ig strand E	184..195	CDD:409407	1/10 (10%)
		Ig strand F	198..207	CDD:409407	3/8 (38%)
		Ig strand G	211..220	CDD:409407	1/8 (13%)
		FN3	225..317	CDD:238020	21/163 (13%)
		fn3	324..406	CDD:394996	28/170 (16%)
		PTKc_Tyro3	508..791	CDD:270659	98/287 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	815..837		6/24 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	851..871		3/14 (21%)