DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Egfr and TEK

DIOPT Version :10

Sequence 1:NP_476759.1 Gene:Egfr / 37455 FlyBaseID:FBgn0003731 Length:1426 Species:Drosophila melanogaster
Sequence 2:NP_000450.3 Gene:TEK / 7010 HGNCID:11724 Length:1124 Species:Homo sapiens


Alignment Length:1292 Identity:269/1292 - (20%)
Similarity:447/1292 - (34%) Gaps:444/1292 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   133 DGNLELT-----WLPNENL----DLSFLDNIR----EVTGYILISHVDV-----KKVVFPKLQI- 178
            |....||     |.|:|.:    |...|.|..    |||       .||     ||||:.:.:. 
Human    37 DAETSLTCIASGWRPHEPITIGRDFEALMNQHQDPLEVT-------QDVTREWAKKVVWKREKAS 94

  Fly   179 -----------IRGRTLFSLSVEEEKYALFVTYSKMYTLEIPDLRDVLNGQVGFHNNYNLCHMRT 232
                       :||..:...:::..:.|.|:..:...|::..|             |.|      
Human    95 KINGAYFCEGRVRGEAIRIRTMKMRQQASFLPATLTMTVDKGD-------------NVN------ 140

  Fly   233 IQWSEIVSNGTDA--YYNYDF--TAPERECPKCHE-SCTHGCWGEGPKNCQKFSKLTCSPQCAGG 292
            |.:.:::....||  |.|..|  :.|..|.|...| ...|.    .|::...:     |.:..||
Human   141 ISFKKVLIKEEDAVIYKNGSFIHSVPRHEVPDILEVHLPHA----QPQDAGVY-----SARYIGG 196

  Fly   293 -------------RC----YGPKPRECCHLFCAGGCTGPTQKDCIACKNFFDEGVCKEE-----C 335
                         ||    :||   ||.||             |.||.|   .|||.|:     |
Human   197 NLFTSAFTRLIVRRCEAQKWGP---ECNHL-------------CTACMN---NGVCHEDTGECIC 242

  Fly   336 PP--MRKYNPTTYVLETNPEGKYAYGATCVKECPGH--------LLRDNGACVRSCPQDKMDKGG 390
            ||  |.:.......|.|       :|.||.:.|.|.        .|.|...|  ||.     .|.
Human   243 PPGFMGRTCEKACELHT-------FGRTCKERCSGQEGCKSYVFCLPDPYGC--SCA-----TGW 293

  Fly   391 ECVPCN--------GP-CPKTCPGVTVLHAGNI-DSFRNCTVIDGNIRILDQTFSGFQ-DVYANY 444
            :.:.||        || |...|.    .:.|.: |.|:.|....|        :.|.| :.....
Human   294 KGLQCNEACHPGFYGPDCKLRCS----CNNGEMCDRFQGCLCSPG--------WQGLQCEREGIQ 346

  Fly   445 TMGPRYIPLDPERLEV----FSTVKEITGY----------LNIEGT--HPQ-FRNLSYFR-NLET 491
            .|.|:.:.| |:.:||    |:.:.:.:|:          :..:||  ||: |.:..:|. .:.|
Human   347 RMTPKIVDL-PDHIEVNSGKFNPICKASGWPLPTNEEMTLVKPDGTVLHPKDFNHTDHFSVAIFT 410

  Fly   492 IHGRQLMESMFAALAIVKSSLYSLEMRNLKQISSGSVVIQHNRDLCYVSNIRWPAIQKEPEQKVW 556
            ||                                        |.|             .|:..||
Human   411 IH----------------------------------------RIL-------------PPDSGVW 422

  Fly   557 VNENLRADLCEKNGTICSDQCNEDGCWGAGTDQCLTCKNFN---------FNGTCIADCGY---- 608
            |        |..| |:            ||    :..|.||         .|...:.|.|:    
Human   423 V--------CSVN-TV------------AG----MVEKPFNISVKVLPKPLNAPNVIDTGHNFAV 462

  Fly   609 --ISNAYKFDN---RTCKICHPECRTCNGAGADHCQECVHVRDGQHCVS----ECPKNKYN---- 660
              ||:...|.:   ::.|:.:..        .:|.:...|::.....|:    | |:.:|.    
Human   463 INISSEPYFGDGPIKSKKLLYKP--------VNHYEAWQHIQVTNEIVTLNYLE-PRTEYELCVQ 518

  Fly   661 --DRGVCRECHATCDGCTGPKDTIGIGACTTCNLAI-----INNDATVKRCLLKDDKCPDGYFWE 718
              .||...|.|      .||     :...||.::.:     :|        ||...:......|:
Human   519 LVRRGEGGEGH------PGP-----VRRFTTASIGLPPPRGLN--------LLPKSQTTLNLTWQ 564

  Fly   719 YVHPQEQGSLKPLAGRAVCRKC---------HPLCELCTNYGYHEQVCSKCTHYKRREQCETECP 774
            .:.|..:........|...:|.         :....|..|....||       |..|.:..|:..
Human   565 PIFPSSEDDFYVEVERRSVQKSDQQNIKVPGNLTSVLLNNLHPREQ-------YVVRARVNTKAQ 622

  Fly   775 ---ADHYTDEEQRECFQCHPECNGCTGPGADDCKSCRNFKLFDANETGPYVNSTMFNCTSKCPLE 836
               ::..|.....:.....||                |.|:.:...:...::.|:.:..|...:.
Human   623 GEWSEDLTAWTLSDILPPQPE----------------NIKISNITHSSAVISWTILDGYSISSIT 671

  Fly   837 MR----------HVN----------YQYTAIGPYCA------------ASPPR---------SSK 860
            :|          ||:          ||...:.|..|            :|.|.         .|:
Human   672 IRYKVQGKNEDQHVDVKIKNATITQYQLKGLEPETAYQVDIFAENNIGSSNPAFSHELVTLPESQ 736

  Fly   861 ITANLDVNMIFIITGAVLVPTICILCVVTYICRQKQKAKKETVKMTMALSGCEDSEPLRPSNIGA 925
            ..|:|....:.:|.........|:..::.::...:.|......:|..|.....: ||....|.| 
Human   737 APADLGGGKMLLIAILGSAGMTCLTVLLAFLIILQLKRANVQRRMAQAFQNVRE-EPAVQFNSG- 799

  Fly   926 NLCKLRIVKD------------AELRKGGVLGMGAFGRVYKGVWVPEGENVKIPVAIKELLKSTG 978
            .|...|.||:            .:::...|:|.|.||:|.|.....:|  :::..|||.:.:...
Human   800 TLALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDG--LRMDAAIKRMKEYAS 862

  Fly   979 AESSEEFLREAYIMASV-EHVNLLKLLAVC-MSSQMMLITQLMPLGCLLDYVRNNR--------- 1032
            .:...:|..|..::..: .|.|::.||..| ....:.|..:..|.|.|||::|.:|         
Human   863 KDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFA 927

  Fly  1033 ------DKIGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSD 1091
                  ..:.|:.||:::..:|:||.||.:|:.:||||||||:||....:.||.||||::   ..
Human   928 IANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSR---GQ 989

  Fly  1092 SNEYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVG 1156
            ....|...|::|::|:|:|.:...|:|:.||||::||.:||:::.|..|:..:...::.:.:..|
Human   990 EVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQG 1054

  Fly  1157 LKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQL----------------TTVFAEF 1197
            .:||:|..|..::|..:..||......||:|.|:                ||::.:|
Human  1055 YRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKTYVNTTLYEKF 1111

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EgfrNP_476759.1 Recep_L_domain 128..239 CDD:460032 27/135 (20%)
Furin-like 253..401 CDD:395614 47/189 (25%)
Recep_L_domain 419..547 CDD:460032 23/146 (16%)
GF_recep_IV 572..684 CDD:464344 24/139 (17%)
FU 662..716 CDD:214589 11/58 (19%)
GF_recep_IV 740..>834 CDD:464344 14/105 (13%)
PTKc_EGFR_like 930..1208 CDD:270648 87/313 (28%)
TEKNP_000450.3 Ig_Tie2_1 24..118 CDD:463089 20/87 (23%)
EGF_Lam 230..275 CDD:238012 15/51 (29%)
EGF_Lam 314..>342 CDD:238012 8/39 (21%)
IgI_Tie2 348..439 CDD:409556 30/169 (18%)
Ig strand A 348..352 CDD:409556 2/3 (67%)
Ig strand A' 358..362 CDD:409556 1/3 (33%)
Ig strand B 365..374 CDD:409556 1/8 (13%)
Ig strand C 382..387 CDD:409556 0/4 (0%)
Ig strand C' 391..393 CDD:409556 1/1 (100%)
Ig strand D 397..401 CDD:409556 1/3 (33%)
Ig strand E 404..412 CDD:409556 2/7 (29%)
Ig strand F 420..428 CDD:409556 5/16 (31%)
Ig strand G 431..439 CDD:409556 3/11 (27%)
fn3 445..520 CDD:394996 13/83 (16%)
fn3 544..626 CDD:394996 14/96 (15%)
FN3 639..731 CDD:238020 15/107 (14%)
PTKc_Tie2 816..1118 CDD:133219 84/301 (28%)

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