DRSC/TRiP Functional Genomics Resources

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Protein Alignment Egfr and Ephb4

DIOPT Version :10

Sequence 1:NP_476759.1 Gene:Egfr / 37455 FlyBaseID:FBgn0003731 Length:1426 Species:Drosophila melanogaster
Sequence 2:XP_003751205.1 Gene:Ephb4 / 686310 RGDID:1583193 Length:996 Species:Rattus norvegicus


Alignment Length:730 Identity:185/730 - (25%)
Similarity:283/730 - (38%) Gaps:183/730 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   577 CNEDGCWGAGTDQCLTCKNFNFNGTCIADCGYISNAYKFDNRTCKICHPECRTCNGAGADHCQEC 641
            |.|||.|   .:|.:|        .|....||.:..   .|:.|:.|        |.|....|  
  Rat   239 CREDGQW---AEQQVT--------GCSCAPGYEAAE---GNKVCRAC--------GQGTFKPQ-- 279

  Fly   642 VHVRDGQHCVSECPKNKY-NDRG----VCR--ECHATCDGCTGPKDTIGIGACTT---CNLAIIN 696
                .|:.....||.|.: |:.|    :||  ...|..|..:.|        |||   ...::::
  Rat   280 ----IGEEPCLPCPANSHSNNIGSPVCLCRIGYYRARSDPRSSP--------CTTPPSAPRSVVH 332

  Fly   697 --NDATVKRCLLKDDKCPDGYFWEYVHPQEQGSLKPLAGRAVCRKCHP--LCELC---------- 747
              |.::::              .|:..|.|.|..:.|.....||:|.|  .|..|          
  Rat   333 HLNGSSLR--------------LEWSAPLESGGREDLTYAVRCRECRPGGSCLPCGGDLTFDPGP 383

  Fly   748 ----------------TNYGYH----EQVCSKCTHYKRREQCETECPADHYTDEEQRECFQCHPE 792
                            ..|.:.    ..|.:..|.....|      |.:..||.|.|..|     
  Rat   384 RDLVEPWVAIRGLRPDVTYTFEVAALNGVSTLATGPPPFE------PVNVTTDREGRTGF----- 437

  Fly   793 CNGCTGPGADDCKSCRN-----------------------FKLFDANETGPYVNSTMFNCTSKCP 834
            .:....|...|.:..|:                       .|..:....||  :|..|..||:..
  Rat   438 LSPAVPPAVSDIRVTRSSPSSLILSWAIPRAPSGAVLDYEVKYHEKGAEGP--SSVRFLKTSENR 500

  Fly   835 LEMRHVNY-----------QYTAIGPYCAASPPRSSKITANLDVNMIFIITGAVLVPTICILCV- 887
            .|:|.:..           .....||:......::....:......:.:|.|..:|..:.:|.| 
  Rat   501 AELRGLKQGASYLVQVRARSEAGYGPFGQEHHSQTQLDESESWREQLALIAGTAVVGVVLVLVVI 565

  Fly   888 -VTYICRQKQKAKKET--------------VKMTMALSGCED-SEPLRPSNIGANLCKLRIVKDA 936
             :..:|.:||.:.:|.              .|:.:.....|| :|.:|..   |....:..||..
  Rat   566 IIAVLCLRKQSSGREVEYSDKHGQYLIGHGTKVYIDPFTYEDPNEAVREF---AKEIDVSYVKIE 627

  Fly   937 ELRKGGVLGMGAFGRVYKGVWVPEGENVKIP------VAIKELLKSTGAESSEEFLREAYIMASV 995
            |     |:|.|.||.|.:|       .:|.|      ||||.|..........|||.||.||...
  Rat   628 E-----VIGAGEFGEVCRG-------RLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQF 680

  Fly   996 EHVNLLKLLAVCMSS-QMMLITQLMPLGCLLDYVRNNRDKIGSKALLNWSTQIAKGMSYLEEKRL 1059
            ||.|:::|..|..:| .:|::|:.|..|.|..::|.|..:.....|:.....||.||.||.|...
  Rat   681 EHPNIIRLEGVVTNSVPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLAEMSY 745

  Fly  1060 VHRDLAARNVLVQTPSLVKITDFGLAKLL---SSDSNEYKAAGGKMPIKWLALECIRNRVFTSKS 1121
            |||||||||:||.:..:.|::||||::.|   |||.....:.|||:||:|.|.|.|..|.|||.|
  Rat   746 VHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTYTSSLGGKIPIRWTAPEAIAFRKFTSAS 810

  Fly  1122 DVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPT 1186
            |.|::|:.:||:::||:||:.::..:|:.:.||...:|..|..|...::..:|.||..|...||.
  Rat   811 DAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCPTSLHQLMLDCWQKDRNARPR 875

  Fly  1187 FKQLTTVFAEFARDP 1201
            |.|:.:...:..|:|
  Rat   876 FPQVVSALDKMIRNP 890

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EgfrNP_476759.1 Recep_L_domain 128..239 CDD:460032
Furin-like 253..401 CDD:395614
Recep_L_domain 419..547 CDD:460032
GF_recep_IV 572..684 CDD:464344 27/113 (24%)
FU 662..716 CDD:214589 10/64 (16%)
GF_recep_IV 740..>834 CDD:464344 24/148 (16%)
PTKc_EGFR_like 930..1208 CDD:270648 104/282 (37%)
Ephb4XP_003751205.1 EphR_LBD_B4 17..196 CDD:198442
FN3 324..429 CDD:238020 17/124 (14%)
fn3 444..527 CDD:394996 13/84 (15%)
EphA2_TM <573..621 CDD:464211 9/50 (18%)
PTKc_EphR_B 619..887 CDD:173638 102/279 (37%)
SAM_EPH-B4 916..982 CDD:188953
Blue background indicates that the domain is not in the aligned region.

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