DRSC/TRiP Functional Genomics Resources

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Protein Alignment Egfr and csf1ra

DIOPT Version :10

Sequence 1:NP_476759.1 Gene:Egfr / 37455 FlyBaseID:FBgn0003731 Length:1426 Species:Drosophila melanogaster
Sequence 2:NP_571747.1 Gene:csf1ra / 64274 ZFINID:ZDB-GENE-001205-1 Length:977 Species:Danio rerio


Alignment Length:581 Identity:142/581 - (24%)
Similarity:242/581 - (41%) Gaps:150/581 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   806 SCRNFKLFDANETGPYVNSTMFNCT---SKC--------PLEMRHVNYQYTAIGPYCAAS----- 854
            |||::..       |..:...:.||   :.|        |::.:.|.:|..:.|.....|     
Zfish   429 SCRSYGY-------PAPSILWYQCTGIRTTCPENTTDLQPIQTQTVEFQKESFGAVGVESVLTVG 486

  Fly   855 PPRSSKI-------------TANLDV-NMIF--IITGAVLVPTICILCVVTYICRQKQKAKKE-T 902
            |.|...:             |.:::| :.||  .:.|:.:...:..|.::..|.:.|||.:.| .
Zfish   487 PNRRMTVVCVAFNLVGQGSDTFSMEVSDQIFTSAMCGSTVAMVVLGLLLIFMIYKYKQKPRYEIR 551

  Fly   903 VKMTMALSGCEDSEPLRPSNIGANLCKLRIVKDAELRKGGVLGMGAFGRVYKGVWVPEGENVKIP 967
            .|:..|.:| .:...:.|:.:..|. |....:| :|:.|..||.||||:|.:......|:...|.
Zfish   552 WKIIEATNG-NNYTFIDPTQLPYNE-KWEFPRD-KLKLGKTLGAGAFGKVVEATAYGLGKEDNIT 613

  Fly   968 -VAIKELLKSTGAESSEEFLREAYIMASV-EHVNLLKLLAVCM-SSQMMLITQLMPLGCLLDYVR 1029
             ||:|.|..|...:..|..:.|..|::.: :|.|::.||..|. ...:::||:....|.||:::|
Zfish   614 RVAVKMLKASAHPDEREALMSELKILSHLGQHKNIVNLLGACTHGGPVLVITEYCCHGDLLNFLR 678

  Fly  1030 NNRDK---------------------------------IGSKA---------------------- 1039
            :..:.                                 |.|..                      
Zfish   679 SKAENFLNFVMTIPNFPEPMTDYKNVSTERMFVRSDSGISSTCSDHYLDMRPVTSRPTNSALDSS 743

  Fly  1040 --------------LLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSS 1090
                          ||.:|:|:|:|:.:|..|..:|||:||||||:....:.||.|||||:.:.:
Zfish   744 SECQEDSWPLDMDDLLRFSSQVAQGLDFLAAKNCIHRDVAARNVLLTNSRVAKICDFGLARDIMN 808

  Fly  1091 DSNEYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPD---- 1151
            |||.......::|:||:|.|.|...|:|.:||||::|:.:||:.:.|:.|:.||    :.|    
Zfish   809 DSNYVVKGNARLPVKWMAPESIFECVYTVQSDVWSYGIMLWEIFSLGKSPYPNI----LVDSKFY 869

  Fly  1152 -LIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARDPGRYLAIPGDKFTRL 1215
             :|:.|.::.:|:....::|..:..||:||||.||||.:::.:                  ..|:
Zfish   870 KMIKCGYQMSRPDFAPPEMYTIMKMCWNLDAAERPTFSKISQM------------------IQRM 916

  Fly  1216 PAYTSQDEKDLIRKLAPTTDGSEAIAEPDDYLQPKAAPGPSHRTDCTDE-----IPKLNRY 1271
            ...||:.:.....|..||...:|...|..|   |......|..|.|..|     :.|.|.|
Zfish   917 LGETSEQQDTQEYKNIPTEAEAEQQLESCD---PVKHEDESFETSCDQEEEDQPLMKPNNY 974

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EgfrNP_476759.1 Recep_L_domain 128..239 CDD:460032
Furin-like 253..401 CDD:395614
Recep_L_domain 419..547 CDD:460032
GF_recep_IV 572..684 CDD:464344
FU 662..716 CDD:214589
GF_recep_IV 740..>834 CDD:464344 7/38 (18%)
PTKc_EGFR_like 930..1208 CDD:270648 94/354 (27%)
csf1raNP_571747.1 Ig_2 41..110 CDD:464026
IG_like 126..200 CDD:214653
Ig 226..306 CDD:472250
Ig strand B 230..234 CDD:409551
Ig strand C 244..248 CDD:409551
Ig strand E 272..276 CDD:409551
Ig strand F 286..291 CDD:409551
Ig strand G 299..302 CDD:409551
Ig 311..410 CDD:472250
Ig strand B 337..341 CDD:409364
Ig strand C 351..354 CDD:409364
Ig strand E 378..382 CDD:409364
Ig strand F 392..397 CDD:409364
Ig strand G 405..408 CDD:409364
Regulatory juxtamembrane domain. /evidence=ECO:0000250 544..576 8/33 (24%)
PTKc_CSF-1R 545..918 CDD:133237 103/397 (26%)
Activation loop. /evidence=ECO:0000250 799..821 8/21 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 919..977 16/59 (27%)
Blue background indicates that the domain is not in the aligned region.

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