DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Egfr and Kit

DIOPT Version :10

Sequence 1:NP_476759.1 Gene:Egfr / 37455 FlyBaseID:FBgn0003731 Length:1426 Species:Drosophila melanogaster
Sequence 2:NP_071600.1 Gene:Kit / 64030 RGDID:620568 Length:978 Species:Rattus norvegicus


Alignment Length:1057 Identity:218/1057 - (20%)
Similarity:338/1057 - (31%) Gaps:408/1057 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   349 ETNPEGKYAYGATCVKECPGHLLR------------------------DNGACVRSCP-QDKMDK 388
            |....|||    |||.   |..||                        ||.|.|| || .|....
  Rat    88 EATHTGKY----TCVS---GSGLRSSIYVFVRDPAVLFLVGLPLFGKEDNDALVR-CPLTDPQVS 144

  Fly   389 GGECVPCNG----------PCPKTCPGVTVLHAGNIDSFRNCTVIDGNIRILDQTFSGFQDVYAN 443
            ....:.|:|          |.||.  |:|:.:.... ..|.|      ||...|...        
  Rat   145 NYSLIECDGKSLPTDLKFVPNPKA--GITIKNVKRA-YHRLC------IRCAAQREG-------- 192

  Fly   444 YTMGPRYIPLDPERLEVFSTVKEI-------TGYLNIEGTHPQFRNLSYFRNLETIHGRQLMESM 501
                 :::..|...|:|.:.:|.|       |.:|..||                        ..
  Rat   193 -----KWMRSDKFTLKVRAAIKAIPVVSVPETSHLLKEG------------------------DT 228

  Fly   502 FAALAIVKSSLYSLEMRNLKQISSGSVVIQHNRDLCYVSNIRWPAIQKEPEQKVWVNENL--RAD 564
            |..:..:|....|::.                         .|..:..:|:.|..|..|.  :.|
  Rat   229 FTVICTIKDVSTSVDS-------------------------MWIKLNPQPQSKAQVKRNSWHQGD 268

  Fly   565 L---CEKNGTICSDQCNEDGCWGAGTDQCLTCKNF---NFNGTC-IADCGYISNAYKFDNRTCKI 622
            .   .::..||.|.:.|:.|.:     .|.....|   |...|. :.:.|:| |.:...|.|..:
  Rat   269 FNYERQETLTISSARVNDSGVF-----MCYANNTFGSANVTTTLKVVEKGFI-NIFPVKNTTVFV 327

  Fly   623 CHPECRTCNGAGADHCQECVHVRDGQH----CVSECPKNKYNDRGVCRECHATCDG--------- 674
                   .:|...|...|.......:|    .::..|.|:..|       :...|.         
  Rat   328 -------TDGENVDLVVEFEAYPKPEHQQWIYMNRTPTNRGED-------YVKSDNQSNIRYVNE 378

  Fly   675 --CTGPKDTIGIGACTTCNLAIINNDATVKRCLLKDDKCPDGYFWEYVHPQEQGSLKPLAGRAVC 737
              .|..|.|.|    .|....:.|:|.:....           |..||      :.||       
  Rat   379 LRLTRLKGTEG----GTYTFLVSNSDVSASVT-----------FDVYV------NTKP------- 415

  Fly   738 RKCHPLCELCTNYGYHEQVCSKCTHYKRREQCETECPA--------DHY--TDEEQRECFQCHPE 792
                   |:.|              |.|......:|.|        |.|  |..|||        
  Rat   416 -------EILT--------------YDRLMNGRLQCVAAGFPEPTIDWYFCTGAEQR-------- 451

  Fly   793 CNGCTGP---------------------------------GADDCKSCRNFKLFDANETGPYVNS 824
               ||.|                                 |..:||:        :|..|.  :|
  Rat   452 ---CTVPVPPVDVQIQNASVSPFGKLVVQSSIDSSVFRHNGTVECKA--------SNAVGK--SS 503

  Fly   825 TMFNCTSKCPLEMRHVNYQYTAIGPYCAASPPRSSKITANLDVNMIFIITGAVLVPTICILCVVT 889
            ..||...|        ......|.|:...:|           :.:.|::|..::.   .|:.|:.
  Rat   504 AFFNFAFK--------GNSKEQIQPHTLFTP-----------LLIGFVVTAGLMG---IIVMVLA 546

  Fly   890 YICRQKQKAKKETVKMTMALSGCE-----------DSEPLRPSNIGANLCKLRIVKDAELRKGGV 943
            |...||...:.:. |:...::|..           |.:...|.|              .|..|..
  Rat   547 YKYLQKPMYEVQW-KVVEEINGNNYVYIDPTQLPYDHKWEFPRN--------------RLSFGKT 596

  Fly   944 LGMGAFGRVYKGVWVPEG---ENVKIPVAIKELLKSTGAESSEEFLREAYIMASV-EHVNLLKLL 1004
            ||.||||:|.:.  ...|   .:..:.||:|.|..|......|..:.|..:::.: .|:|::.||
  Rat   597 LGAGAFGKVVEA--TAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLL 659

  Fly  1005 AVC-MSSQMMLITQLMPLGCLLDYVRNNRDK-IGSKA---------------------------- 1039
            ..| :....::||:....|.||:::|..||. |.||.                            
  Rat   660 GACTVGGPTLVITEYCCYGDLLNFLRRKRDSFIFSKQEEQADAALYKNLLHSKESSCDSSNEYMD 724

  Fly  1040 ---------------------------------------------LLNWSTQIAKGMSYLEEKRL 1059
                                                         ||::|.|:||||::|..|..
  Rat   725 MKPGVSYVVPTKTDKRRSARIDSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNC 789

  Fly  1060 VHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAGGKMPIKWLALECIRNRVFTSKSDVW 1124
            :||||||||:|:....:.||.|||||:.:.:|||.......::|:||:|.|.|.|.|:|.:||||
  Rat   790 IHRDLAARNILLTHGRITKICDFGLARDIRNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVW 854

  Fly  1125 AFGVTIWELLTFGQRPHENIPA-KDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFK 1188
            ::|:.:|||.:.|..|:..:|. .....:|:.|.::..||.....:|..:.:||..|...|||||
  Rat   855 SYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAAMYEVMKTCWDADPLKRPTFK 919

  Fly  1189 QLTTVFAEFARDPGRYL 1205
            |:..:..:...|..:::
  Rat   920 QVVQLIEKQISDSSKHI 936

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EgfrNP_476759.1 Recep_L_domain 128..239 CDD:460032
Furin-like 253..401 CDD:395614 21/86 (24%)
Recep_L_domain 419..547 CDD:460032 17/134 (13%)
GF_recep_IV 572..684 CDD:464344 24/130 (18%)
FU 662..716 CDD:214589 8/64 (13%)
GF_recep_IV 740..>834 CDD:464344 24/136 (18%)
PTKc_EGFR_like 930..1208 CDD:270648 97/356 (27%)
KitNP_071600.1 Ig_3 36..98 CDD:464046 5/13 (38%)
ig 216..307 CDD:395002 21/144 (15%)
Ig strand B 229..233 CDD:409353 1/3 (33%)
Ig strand C 243..247 CDD:409353 0/28 (0%)
Ig strand E 275..279 CDD:409353 0/3 (0%)
Ig strand F 289..294 CDD:409353 1/9 (11%)
Ig strand G 302..305 CDD:409353 1/2 (50%)
IgI_4_SCFR 313..413 CDD:409446 23/135 (17%)
Ig strand A 313..319 CDD:409446 3/6 (50%)
Ig strand A' 323..328 CDD:409446 1/11 (9%)
Ig strand B 331..341 CDD:409446 2/9 (22%)
Ig strand C 345..352 CDD:409446 1/6 (17%)
Ig strand C' 354..357 CDD:409446 0/2 (0%)
Ig strand D 360..365 CDD:409446 1/11 (9%)
Ig strand E 374..383 CDD:409446 0/8 (0%)
Ig strand F 390..398 CDD:409446 1/7 (14%)
Ig strand G 401..412 CDD:409446 3/27 (11%)
Ig_3 414..497 CDD:464046 20/129 (16%)
Protein Kinases, catalytic domain 555..929 CDD:473864 101/390 (26%)
Blue background indicates that the domain is not in the aligned region.

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