DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Egfr and Erbb4

DIOPT Version :9

Sequence 1:NP_476759.1 Gene:Egfr / 37455 FlyBaseID:FBgn0003731 Length:1426 Species:Drosophila melanogaster
Sequence 2:NP_067719.2 Gene:Erbb4 / 59323 RGDID:620486 Length:1308 Species:Rattus norvegicus


Alignment Length:1426 Identity:503/1426 - (35%)
Similarity:686/1426 - (48%) Gaps:344/1426 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   101 ICIGTKSRLSVPSNKEHHYRNLRDRYTNCTYVDGNLELTWLPNENLDLSFLDNIREVTGYILISH 165
            :|.||:::||..|:.|..||.||..|.||..|.||||:|.: ..|.|||||.:|||||||:|::.
  Rat    28 VCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSI-EHNRDLSFLRSIREVTGYVLVAL 91

  Fly   166 VDVKKVVFPKLQIIRGRTLFSLSVEEEKYAL--FVTYSK-----MYTLEIPDLRDVLNGQVGFHN 223
            ...:.:....|:||||..|:     |::|||  |:.|.|     :..|.:.:|.::|||.|....
  Rat    92 NQFRYLPLENLRIIRGTKLY-----EDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVDQ 151

  Fly   224 NYNLCHMRTIQWSEIVSNGTDAYYNYDFTAPERECPKCHESCTHGCWGEGPKNCQKFSKLTCSPQ 288
            |..||:..||.|.:||.|...:......|.....|.:||:|||..|||....:||..::..|:.|
  Rat   152 NKFLCYADTIHWQDIVRNPWPSNMTLVSTIGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQ 216

  Fly   289 CAGGRCYGPKPRECCHLFCAGGCTGPTQKDCIACKNFFDEGVCKEECPPMRKYNPTTYVLETNPE 353
            | .||||||...:|||..|||||:||...||.||.||.|.|.|..:||....|||||:.||.|..
  Rat   217 C-DGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFN 280

  Fly   354 GKYAYGATCVKECPGHLLRDNGACVRSCPQDKM--DKGG--ECVPCNGPCPKTCPGV-------- 406
            .||.|||.|||:||.:.:.|:.:|||:||..||  ::.|  .|.||...|||.|.|:        
  Rat   281 AKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSA 345

  Fly   407 TVLHAGNIDSFRNCTVIDGNIRILDQTFSGFQDVYANYTMGPRYIPLDPERLEVFSTVKEITGYL 471
            ..:.:.|||.|.|||.|:||:..|.....|  |.|....      .:|||:|.||.||:||||:|
  Rat   346 QTVDSSNIDKFINCTKINGNLIFLVTGIHG--DPYNAID------AIDPEKLNVFRTVREITGFL 402

  Fly   472 NIEGTHPQFRNLSYFRNLETIHGRQLMESMFAALAIVKSSLYSLEMRNLKQISSGSVVIQHNRDL 536
            ||:...|...:.|.|.||.||.||.|...: :.|.:.:..:.||:.::||:||:|::.|..|.:|
  Rat   403 NIQSWPPNMTDFSVFSNLVTIGGRVLYSGL-SLLILKQQGITSLQFQSLKEISAGNIYITDNSNL 466

  Fly   537 CYVSNIRWPAIQKEPEQKVWVNENLRADLCEKNGTICSDQCNEDGCWGAGTDQCLTCKNFNFNGT 601
            ||...|.|..:.....|::.:.:|.||:.|...|.:|:..|:.|||||.|.||||:|:.|:....
  Rat   467 CYYHTINWTTLFSTVNQRIVIRDNRRAENCTAEGMVCNHLCSNDGCWGPGPDQCLSCRRFSRGKI 531

  Fly   602 CIADCGYISNAYK-FDNRT-CKICHPECR-------TCNGAGADHCQECVHVRDGQHCVSECPKN 657
            ||..|......:: |:|.: |..|..:|.       ||:|.|.|:|.:|.|.:||.:||.:||  
  Rat   532 CIESCNLYDGEFREFENGSICVECDSQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCP-- 594

  Fly   658 KYNDRGVCRECHATCDGCTGPKDTIGIGACTTCNLAIINNDATVKRCLLKDDKCPDGYFWEYVHP 722
                           ||..|....|                                        
  Rat   595 ---------------DGLQGANSFI---------------------------------------- 604

  Fly   723 QEQGSLKPLAGRAVCRKCHPLCELCTNYGYHEQVCSKCTHYKRREQCETECPADHYTDEEQRECF 787
                                                    :|             |.|:: |||.
  Rat   605 ----------------------------------------FK-------------YADQD-RECH 615

  Fly   788 QCHPEC-NGCTGPGADDCKSCRNFKLFDANETGPYVNSTMFNCTSKCPLEMRHVNYQYTAIG--P 849
            .|||.| .||.||.:.||                                   :.|.:|...  |
  Rat   616 PCHPNCTQGCNGPTSHDC-----------------------------------IYYPWTGHSTLP 645

  Fly   850 YCAASPPRSSKITANLDVNMIFIITGAVLVPTICILCVVTYICRQKQKAKKETVKMTMALSGCED 914
            ..|.:|..::.:...|.:.:|..:|.||.|             |:|...||..::..:.   .|.
  Rat   646 QHARTPLIAAGVIGGLFILVIMALTFAVYV-------------RRKSIKKKRALRRFLE---TEL 694

  Fly   915 SEPLRPSNIGANLCKLRIVKDAELRKGGVLGMGAFGRVYKGVWVPEGENVKIPVAIKELLKSTGA 979
            .|||.||....|..:|||:|:.||::..|||.||||.||||:||||||.||||||||.|.::||.
  Rat   695 VEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGP 759

  Fly   980 ESSEEFLREAYIMASVEHVNLLKLLAVCMSSQMMLITQLMPLGCLLDYVRNNRDKIGSKALLNWS 1044
            :::.||:.||.|||||:|.:|::||.||:|..:.|:|||||.||||:||..::|.|||:.||||.
  Rat   760 KANVEFMDEALIMASVDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWC 824

  Fly  1045 TQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAGGKMPIKWLAL 1109
            .||||||.||||:||||||||||||||::|:.|||||||||:||..|..||.|.||||||||:||
  Rat   825 VQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMAL 889

  Fly  1110 ECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLL 1174
            |||..|.||.:||||::|||||||:|||.:|::.||.::||||:|.|.:|.||.||::|:|..::
  Rat   890 ECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMV 954

  Fly  1175 SCWHLDAAMRPTFKQLTTVFAEFARDPGRYLAIPGDKFTRLPAYTSQ-------DEKDLIRKLAP 1232
            .||.:||..||.||:|...|:..||||.|||.|.||...:||:....       ||:||      
  Rat   955 KCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDL------ 1013

  Fly  1233 TTDGSEAIAEPDDYLQPKA--APGP---------SHRTDCTDEIPKL------NRYCKD------ 1274
                 |.:.:.::||.|:|  .|.|         |:|::.....|..      |::...      
  Rat  1014 -----EDMMDAEEYLVPQAFNIPPPIYTSRTRIDSNRSEIGHSPPPAYTPMSGNQFVYQDGGFAT 1073

  Fly  1275 ------PSNKNSST--------------GDD---------------ETDSSAREVGVG------- 1297
                  |....:||              .||               :.|||.:.....       
  Rat  1074 QQGMPMPYRATTSTIPEAPVAQGATAEMFDDSCCNGTLRKPVVPHVQEDSSTQRYSADPTVFAPE 1138

  Fly  1298 -NLRLDLPVDEDDYLMPTCQPGPNNNNNINNPNQNNMAAVGVAAGYMDLIGVPVSVDNPEYLLNA 1361
             |.|.:|  ||:.|:.|.   .........||.:.|........|.:.      ::|||||    
  Rat  1139 RNPRAEL--DEEGYMTPM---HDKPKQEYLNPVEENPFVSRRKNGDLQ------ALDNPEY---- 1188

  Fly  1362 QTLGVGESPIPTQTIGIPVMGVPGTMEVKVPMPGSEPTSSDHEYYNDTQRELQPLHRNRNT 1422
                                          ....|.|..::.||.|      :||:.|..|
  Rat  1189 ------------------------------HSASSGPPKAEDEYVN------EPLYLNTFT 1213

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EgfrNP_476759.1 Recep_L_domain 419..547 CDD:279382 50/127 (39%)
GF_recep_IV 572..684 CDD:291509 40/120 (33%)
FU 573..>606 CDD:238021 16/32 (50%)
FU 617..659 CDD:214589 18/49 (37%)
FU 662..716 CDD:214589 4/53 (8%)
FU 739..786 CDD:238021 4/46 (9%)
FU 784..834 CDD:214589 13/50 (26%)
PTKc_EGFR_like 930..1208 CDD:270648 173/277 (62%)
STYKc 938..1194 CDD:214568 160/255 (63%)
Recep_L_domain 128..239 CDD:279382 47/117 (40%)
Furin-like 253..401 CDD:279142 72/151 (48%)
FU 255..292 CDD:214589 14/36 (39%)
FU 302..345 CDD:238021 24/42 (57%)
Erbb4NP_067719.2 Recep_L_domain 55..167 CDD:395817 47/117 (40%)
Furin-like 186..332 CDD:395614 72/146 (49%)
Recep_L_domain 358..478 CDD:395817 50/128 (39%)
GF_recep_IV 502..634 CDD:405525 56/277 (20%)
TM_ErbB4 642..685 CDD:213053 13/55 (24%)
Nuclear localization signal. /evidence=ECO:0000250 676..684 3/7 (43%)
PTKc_HER4 710..1012 CDD:173655 180/301 (60%)
PPxy motif 1 1032..1035 1/2 (50%)
PPxY motif 2 1298..1301
PDZ-binding 1306..1308
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 339 1.000 Domainoid score I1062
eggNOG 1 0.900 - - E1_KOG1025
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG45861
OrthoDB 1 1.010 - - D51516at33208
OrthoFinder 1 1.000 - - FOG0000755
OrthoInspector 1 1.000 - - otm44735
orthoMCL 1 0.900 - - OOG6_101159
Panther 1 1.100 - - O PTHR24416
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X448
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1110.790

Return to query results.
Submit another query.