Protein Alignment Egfr and ephb6

DIOPT Version :10

• Sequence 1: NP_476759.1
• Gene: Egfr / 37455
• FlyBaseID: FBgn0003731
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: XP_005173575.1
• Gene: ephb6 / 572411
• ZFINID: ZDB-GENE-100922-51
• Length: 1003
• Species: Danio rerio
• Alignment Length: 1005
• Identity: 229/1005 - (22%)
• Similarity: 359/1005 - (35%)
• Gaps: 274/1005 - (27%)

  Fly   391 ECVPCNGPCPKTCPGVTVLHAGNIDSFRNCTVIDGNIRILDQTFSGFQDVYANYTMGPR---YIP 452
            :|.....|.| ||.....|:....||.|.          |::|::      |..:.|..   ::.
Zfish    99 DCASLRSPSP-TCRETLTLYYKQADSQRE----------LERTWA------AEASSGETREGWVK 146

  Fly   453 LDPERLEVFSTVKEITGYLNIEGTHP-QFRNLSYFR-NLETIHGRQLMESMFAALAIVKSSLYSL 515
            :|        |:.....:..:|.:.| |:::.:..| |::|.....|....| .||||.|...
Zfish   147 ID--------TIAADKSFSRVEPSLPHQYKSENARRINVKTRSFAPLTRKGF-VLAIVDSGAC-- 200

  Fly   516 EMRNLKQISSGSVVIQHNRDLCYVSN---IRWPAIQK--EPEQKVWVNENLRADLCEKNGTICSD 575
                   :|...|.|.:.|  |..::   ..:||...  ||...|.|..........:.||....
Zfish   201 -------VSLMGVSIFYRR--CPATSRFLAFYPATPSGAEPTSLVPVTGTCVPHSQSQGGTAPRM 256

  Fly   576 QCNEDGCWGAGTDQCLTCKNFNFNGTCIADCGYISNAYKFDNRTCKICHPECRTCNGAGADHCQE 640
            .||.:|.|....            |.|..|.||..|   .:...|.:| |.......||:..|
Zfish   257 HCNTEGEWLVPV------------GGCTCDAGYEPN---HNGSACLVC-PIGSYKAVAGSVSC-- 303

  Fly   641 CVHVRDGQHCVSECPKNKYNDRGVCRECHATCDGCTGPKDTIGIGACTTCNLAIINNDATVKRCL 705
                       :|||.|........:.|.........|.|. ...|||:
Zfish   304 -----------TECPANSRTSSEGAKVCECRSGYYRAPADA-NTTACTS---------------- 340

  Fly   706 LKDDKCPDGYFWEYVHPQEQGSLK-----PLAGR------AVCRKC-------HPLCELC----- 747
              ....|....|||...:...||:     .:.||      .|||.|       ..:|..|
Zfish   341 --SPSAPLALSWEYESSEGGVSLRWRPPADMGGRTDVWYGVVCRICPSATSTPPSMCSWCGETVT 403

  Fly   748 -------------------TNYGYHEQVCS--------------KCTHYKRREQCETECPADH-- 777
                               |...|..||.:              ...::...:...:|.|..|
Zfish   404 YSPSQNGLKQTRVTLKNLLTRVTYLIQVQAMNEVSALSPFPPQFASINFTTSQSVPSEVPMLHQL 468

  Fly   778 ---------------------------YTDE--EQRECFQCHPECNGCTG----PGADDCKSCRN 809
                                       |.|:  ::......:.|.|..|.    ||     |...
Zfish   469 SRVQDSITLSWPQPDRPNGDILEYQLRYYDKGSDEDSALSMYSETNTVTVTGLIPG-----SIYA 528

  Fly   810 FKLFDANET--GPYVNSTMFNCTSKCPLEMRHVNYQYTAIGPYCAASPPRSSKITANLDVNMIFI 872
            |::...||.  |||.::..|:                      ..||..:|.:|...|.: ||..
Zfish   529 FQIRARNERGFGPYSHTIYFS----------------------TLASEGQSKQIQNRLPL-MIGS 570

  Fly   873 ITGAVLVPTICILCVVTYICRQKQK------------AKKETVKMTMALSGCED-SEPLRPSNIG 924
            :.|......:.|..::.::.|.|::            :.:..||..:..|..|| ||.::..
Zfish   571 VMGGAAFLLVVIAIIIVFVFRSKRRESPYSDRLQRYISNRGGVKYYVDPSTYEDPSEAVKEF--- 632

  Fly   925 ANLCKLRIVKDAELRKGGVLGMGAFGRVYKGVWVPEGENVKIPVAIKELLKSTGAESSEEFLREA 989
                 .|.:..|.|:...|:|...||.|.:|.:.|.|....: ||:|.|...........||.||
Zfish   633 -----AREIDPAHLKIEEVIGAAQFGEVSRGRYRPIGRREAL-VAVKTLRWGVTEREKNVFLSEA 691

  Fly   990 YIMASVEHVNLLKLLAV-CMSSQMMLITQLMPLGCLLDYVRNNRDKIGSKALLNWSTQIAKGMSY 1053
            .::...:|.|:|||..| ..:....:||:.|..|.|..::|.|.|:.....|:.....:..||.|
Zfish   692 GVLGQFDHPNVLKLEGVITRTPPERIITEFMENGPLDAFLRENEDQFSVLQLVGMVRGVGAGMRY 756

  Fly  1054 LEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSS-DSN--EYKAA-GGKMPIKWLALECIRN 1114
            |.|:..||||||||||||.:..:.|::||||::|:.. |.|  .|.|: |.|:|::|.|.|..::
Zfish   757 LSERNFVHRDLAARNVLVNSNLVCKVSDFGLSRLMRGLDHNMPTYTASLGSKIPVRWTAPEAFQH 821

  Fly  1115 RVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHL 1179
            |.|:|.||||:||:.:||::::|:||:.::..:::...:....:|..|..|...::..:|.||..
Zfish   822 RKFSSASDVWSFGILMWEVMSYGERPYWDMSNQEVMKAVVDQYRLPAPNGCPPALHSLMLQCWQA 886

  Fly  1180 DAAMRPTFKQLTTVFAEFARDPGRYLAIPGDKFTRLPAYTSQDEKDLIRKLAPTTDGSEAIAEPD 1244
            |...||.|..|.:......|.|           ..|.|..|:..:.|   |:||.....::....
Zfish   887 DRQDRPGFDSLLSSLDRLIRHP-----------ASLKAEHSRPTQPL---LSPTPTDLSSVNTVG 937

  Fly  1245 DYLQPKAAPGPSHRTDCTDEIPKLNRYCKD 1274
            |:|                .:.|::|| ||
Zfish   938 DWL----------------TVLKMDRY-KD 950

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Egfr	NP_476759.1	Recep_L_domain	128..239	CDD:460032
		Furin-like	253..401	CDD:395614	2/9 (22%)
		Recep_L_domain	419..547	CDD:460032	25/135 (19%)
		GF_recep_IV	572..684	CDD:464344	23/111 (21%)
		FU	662..716	CDD:214589	7/53 (13%)
		GF_recep_IV	740..>834	CDD:464344	25/175 (14%)
		PTKc_EGFR_like	930..1208	CDD:270648	94/282 (33%)
ephb6	XP_005173575.1	Ephrin_lbd	22..213	CDD:460198	32/150 (21%)
		Ephrin_rec_like	<286..318	CDD:429604	10/45 (22%)
		FN3	<336..>552	CDD:442628	39/260 (15%)
		FN3	473..550	CDD:238020	15/103 (15%)
		EphA2_TM	568..638	CDD:464211	13/77 (17%)
		Protein Kinases, catalytic domain	636..905	CDD:473864	91/269 (34%)
		SAM_superfamily	932..987	CDD:472832	7/36 (19%)