DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Egfr and erbb4b

DIOPT Version :9

Sequence 1:NP_476759.1 Gene:Egfr / 37455 FlyBaseID:FBgn0003731 Length:1426 Species:Drosophila melanogaster
Sequence 2:XP_009303149.2 Gene:erbb4b / 569836 ZFINID:ZDB-GENE-030918-5 Length:1374 Species:Danio rerio


Alignment Length:1445 Identity:495/1445 - (34%)
Similarity:687/1445 - (47%) Gaps:335/1445 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   100 KICIGTKSRLSVPSNKEHHYRNLRDRYTNCTYVDGNLELTWLPNENLDLSFLDNIREVTGYILIS 164
            ::|.||:::||..|:.:..||.||..|.||..|.||||:|.: :.:.|||||.:|||||||:|::
Zfish    26 QVCTGTENKLSTLSDLDQQYRTLRKYYENCEVVMGNLEITSI-DRSRDLSFLRSIREVTGYVLVA 89

  Fly   165 HVDVKKVVFPKLQIIRGRTLFSLSVEEEKYAL--FVTYSK-----MYTLEIPDLRDVLNGQVGFH 222
            ....:.:....|:||||..|:     |::|||  |:.|.:     :..|.:.:|.::|||.|...
Zfish    90 LNQFEYLPLENLRIIRGTRLY-----EDRYALAIFLNYRRDGNFGLRQLGLKNLTEILNGGVYVD 149

  Fly   223 NNYNLCHMRTIQWSEIVSNGTDAYYNYDFTAPER---ECPKCHESCTHGCWGEGPKNCQKFSKLT 284
            .|..|||..||.|.:||.|....:    ...|..   .|.:||.:|...|||.....||..:|..
Zfish   150 QNKFLCHADTIHWQDIVKNARPDH----LVVPSNSSSSCQRCHRACNGRCWGPKEDQCQSLTKTV 210

  Fly   285 CSPQCAGGRCYGPKPRECCHLFCAGGCTGPTQKDCIACKNFFDEGVCKEECPPMRKYNPTTYVLE 349
            |:.|| .|||:||...:|||..|||||:||...||.||.||.|.|.|..:||....|||||:.||
Zfish   211 CAEQC-DGRCFGPYVSDCCHPECAGGCSGPKNTDCFACTNFNDSGACVTQCPRPFVYNPTTFQLE 274

  Fly   350 TNPEGKYAYGATCVKECPGHLLRDNGACVRSCPQDKMD----KGGECVPCNGPCPKTCPGV---- 406
            .||..||.|||.|||:||.:.:.|:.:|||:||.:||:    :...|:||...|||.|.|:    
Zfish   275 HNPWAKYTYGAFCVKKCPHNFVVDHSSCVRACPSNKMEVEENRIKMCIPCTDICPKACDGIGTAS 339

  Fly   407 ----TVLHAGNIDSFRNCTVIDGNIRILDQTFSGFQDVYANYTMGPRYIPLDPERLEVFSTVKEI 467
                ..:.:.|||.|.|||.|:||:..|.....|  |||.|..      |||||:|.||.||:||
Zfish   340 LQTAQTVDSSNIDRFINCTKINGNLVFLITGIKG--DVYHNIE------PLDPEKLNVFRTVREI 396

  Fly   468 TGYLNIEGTHPQFRNLSYFRNLETIHGRQLMESMFAALAIVKSS-LYSLEMRNLKQISSGSVVIQ 531
            ||:|||:.......:||.|.||.||.||.|...:  :|.::|.. :.|:::::|::||:|:|.:.
Zfish   397 TGFLNIQSWPENMTDLSVFSNLATIGGRALYSGI--SLLVLKQQWITSMQLQSLREISAGNVYVT 459

  Fly   532 HNRDLCYVSNIRWPAIQKEPEQKVWVNENLRADLCEKNGTICSDQCNEDGCWGAGTDQCLTCKNF 596
            :|..|||.:.:.|..:.:...||..:..|.....|..:..:|...|::.||||.|.||||:|:.|
Zfish   460 NNSQLCYYNTVNWTRLFRINTQKALIRNNRDPKECILDRMVCDPLCSDAGCWGPGPDQCLSCRFF 524

  Fly   597 NFNGTCIADCGYISNAYKFDNR------TCKICHPECR-------TCNGAGADHCQECVHVRDGQ 648
            ....||:..|    |.::.|.|      .|..|..:|.       ||.|.|.|||.:|.|.:||.
Zfish   525 IRGRTCVESC----NLHEGDVREFANGSVCLECDAQCEVPEDDALTCTGPGPDHCVKCRHFKDGP 585

  Fly   649 HCVSECPKNKYNDRGVCRECHATCDGCTGPKDTIGIGACTTCNLAIINNDATVKRCLLKDDKCPD 713
            :||.:||                 ||..|                                  ..
Zfish   586 NCVEKCP-----------------DGLQG----------------------------------AS 599

  Fly   714 GYFWEYVHPQEQGSLKPLAGRAVCRKCHPLCELCTNYGYHEQVCSKCTHYKRREQCETECPADHY 778
            .:.::|.                                                          
Zfish   600 SFIFKYA---------------------------------------------------------- 606

  Fly   779 TDEEQRECFQCHPEC-NGCTGPGADDCKSCRNFKLFDANETGPYVNSTMFNCTSKCPLEMRHVNY 842
              |...||..||..| .|||||...||                      .....:.||       
Zfish   607 --EANNECHPCHVNCTQGCTGPRLQDC----------------------IGVMDRTPL------- 640

  Fly   843 QYTAIGPYCAASPPRSSKITANLDVNMIFIITGAVLVPTICILCVVTYICRQKQKAKKETVKMTM 907
                              |.|.        :.|.:.|..|..|.|...: |:|...||..::..:
Zfish   641 ------------------IAAG--------VIGGLFVVIIIGLSVAISV-RRKSIKKKRALRRFL 678

  Fly   908 ALSGCEDSEPLRPSNIGANLCKLRIVKDAELRKGGVLGMGAFGRVYKGVWVPEGENVKIPVAIKE 972
            .   .|..|||.||....|..:|||:|:.||::..:||.||||.||||:||||||.||||||||.
Zfish   679 E---TELVEPLTPSGAAPNQAQLRILKETELKRVKILGAGAFGTVYKGIWVPEGETVKIPVAIKI 740

  Fly   973 LLKSTGAESSEEFLREAYIMASVEHVNLLKLLAVCMSSQMMLITQLMPLGCLLDYVRNNRDKIGS 1037
            |.::||.:::.||:.||.||||:||.:|::||.||:|..:.|:|||||.|||||||..::|.|||
Zfish   741 LNEATGPKANVEFMDEALIMASMEHPHLVRLLGVCLSPTIQLVTQLMPHGCLLDYVHEHKDNIGS 805

  Fly  1038 KALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAGGKM 1102
            :.||||..||||||.||||:||||||||||||||::|:.:||||||||:||.::..||.|.||||
Zfish   806 QLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHIKITDFGLARLLDANEKEYNADGGKM 870

  Fly  1103 PIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSL 1167
            ||||:|||||..|.||.:||||::|||||||:|||.:|::.||.::||||:|.|.:|.||.||::
Zfish   871 PIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTI 935

  Fly  1168 DIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARDPGRYLAIPGDKFTRLP---------------- 1216
            |:|..::.||.:||..||.||:|...|:..||||.|||.|.||...:||                
Zfish   936 DVYMVMVKCWMIDADSRPRFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQSLLDEEE 1000

  Fly  1217 ---------------------AYTSQDEKDLIRKLAPTTDGSEAIAEPDDYL------------- 1247
                                 |||::...|..|......|||..:   :|.:             
Zfish  1001 LEDLMDAEEYLVPQAYSIPPLAYTTRSRMDPNRNQFAYQDGSFGM---EDMMATIPRVVAVSAVS 1062

  Fly  1248 -------QPKAAPGPSHRTDCTDEIPKLNRYCKDPSNKNSSTGDDET-------------DSSAR 1292
                   |.|...|.|..::..:: .:.|...:..::..:|||||.:             :..||
Zfish  1063 PGCSTQKQSKGQQGASGSSEAFED-SRCNGTLRKKASPRASTGDDSSGQRYSADPTVILCEHGAR 1126

  Fly  1293 EVGVGNLRLDLPVDEDDYL--MPTCQPGPNNNNNINNP---NQNNMAAVGVAAGYMDLI-GVP-- 1349
                      ...|:|.|:  |...:|....|....||   ::.|.....:..||.... |.|  
Zfish  1127 ----------AETDQDGYMSAMQDKKPSDFLNPVEENPFVTHRRNGEVHTLERGYHSTSNGQPKL 1181

  Fly  1350 --VSVDNPEYLLNAQTLGVGESPIPTQTIGIPVMGVPGTMEVKVPMPGSEPTSSDHEYYNDTQR- 1411
              ..|::|.||......| .:|....:..|:||:.........| ...:..|:::|......|. 
Zfish  1182 EDEYVNDPLYLNTFHNTG-EKSHDALRKNGVPVVHTAAAAAATV-AAANTITANNHTLSQTMQPA 1244

  Fly  1412 ------ELQPLHRNR 1420
                  ..|||::.:
Zfish  1245 ASSAHITTQPLYQGK 1259

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EgfrNP_476759.1 Recep_L_domain 419..547 CDD:279382 52/128 (41%)
GF_recep_IV 572..684 CDD:291509 40/124 (32%)
FU 573..>606 CDD:238021 15/32 (47%)
FU 617..659 CDD:214589 19/54 (35%)
FU 662..716 CDD:214589 3/53 (6%)
FU 739..786 CDD:238021 1/46 (2%)
FU 784..834 CDD:214589 12/50 (24%)
PTKc_EGFR_like 930..1208 CDD:270648 171/277 (62%)
STYKc 938..1194 CDD:214568 158/255 (62%)
Recep_L_domain 128..239 CDD:279382 46/117 (39%)
Furin-like 253..401 CDD:279142 71/154 (46%)
FU 255..292 CDD:214589 13/39 (33%)
FU 302..345 CDD:238021 24/42 (57%)
erbb4bXP_009303149.2 Recep_L_domain 54..166 CDD:307256 46/117 (39%)
Furin-like 184..330 CDD:307072 70/146 (48%)
Recep_L_domain 356..476 CDD:307256 52/129 (40%)
GF_recep_IV 500..632 CDD:317276 54/268 (20%)
TM_ErbB4 630..673 CDD:213053 15/98 (15%)
PTKc_HER4 698..1000 CDD:173655 176/301 (58%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 175 1.000 Domainoid score I3585
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG45861
OrthoDB 1 1.010 - - D51516at33208
OrthoFinder 1 1.000 - - FOG0000755
OrthoInspector 1 1.000 - - otm25049
orthoMCL 1 0.900 - - OOG6_101159
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X448
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
87.830

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