DRSC/TRiP Functional Genomics Resources

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Protein Alignment Egfr and epha7

DIOPT Version :10

Sequence 1:NP_476759.1 Gene:Egfr / 37455 FlyBaseID:FBgn0003731 Length:1426 Species:Drosophila melanogaster
Sequence 2:NP_001038444.2 Gene:epha7 / 562195 ZFINID:ZDB-GENE-030131-3745 Length:1016 Species:Danio rerio


Alignment Length:937 Identity:200/937 - (21%)
Similarity:330/937 - (35%) Gaps:303/937 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   454 DPERL--EVFSTVKEITGYLNIEGTHPQFRNLSYFRNLETIHGRQLMESMFAALAIVKSSLYSLE 516
            |.:|:  |:..|:::......:.|:..:..|| |::..:...||.:.||.:..:..:.:.     
Zfish    93 DAQRIFVELKFTLRDCNSLPGVVGSCKETFNL-YYQETDVEVGRNIRESQYVKIDTIAAD----- 151

  Fly   517 MRNLKQISSGSVVIQHNRDLCYVSNIR----WPAIQ-----------KEPEQKVW-VNENLR--- 562
             .:..|...|...::.|.::..:..:.    :.|.|           |...:|.| :.|||.   
Zfish   152 -ESFTQGDLGERKMKLNTEVRIIGPLSRRGFYLAFQDVGACIALVSVKVYYKKCWSIIENLATFP 215

  Fly   563 --------ADLCEKNGTICSD-----------QCNEDGCWGAGTDQCLTCKNFNFNGTCIADCGY 608
                    :.|.|..||..:|           .|:.:|.|.....:|:....|:..|.....|| 
Zfish   216 DTVTGSEFSSLVEVEGTCVNDAEEEADNSPKMHCSAEGEWLVPIGKCICKAGFHQKGDACEPCG- 279

  Fly   609 ISNAYKFDNRTCKICHPECRTCNGAGADHCQECVHVRDGQHCVSECPKNKYNDRGVCRECHATCD 673
             ...||..::..                   :|          |.||.:.||||.....|... |
Zfish   280 -RGFYKSSSQDL-------------------QC----------SRCPAHSYNDREGSWRCDCE-D 313

  Fly   674 G------------CTGPKDTIGIGACTTCNLAIINNDATVKRCLLKDDKCPDGYFWEYVHPQEQG 726
            |            ||.|..       ...||....|..||.              .|:..|.:.|
Zfish   314 GYYRALSDPPSVSCTRPPS-------APQNLLYNINHTTVS--------------LEWTPPADTG 357

  Fly   727 SLKPLAGRAVCRKCHPLCELCTNYGYHEQVCSKCTHYKRREQCETECPADHYTDEEQRECFQC-- 789
            ....:..|.:||:|                                       ..|..|||.|  
Zfish   358 GRNDVTYRIICRRC---------------------------------------TWEPEECFPCGS 383

  Fly   790 ----HPECNGCTGP---------------------GADDCKSCRNFKLFDA-----NETGP---- 820
                .|:.:|.|..                     |..|..  |..:||.|     ::.|.    
Zfish   384 NVGYSPQQSGLTDTYVTITDLLAHANYTFEVEAVNGVSDLS--RTQRLFAAVSIATSQAGSTFFT 446

  Fly   821 ------YVNSTMFNCTSKCPLEMRHV-------------------------NYQ----------- 843
                  |.::.||..|:  |.::..|                         .|:           
Zfish   447 NISVHFYTSADMFEVTA--PSQVSEVIKERVQQHSVQLSWQEPDQPNGVITEYEIKYYEKDQKDR 509

  Fly   844 ----------------------------------YTAIGPYCAASPPRSSKITANL---DVNMIF 871
                                              |...||....:....|..:|.:   :.|.:.
Zfish   510 IYSTVKSKSTSATVNNLKPSTAYVFQIRAFTAAGYGIFGPRLEVTTKEESTGSATVISSEQNPVI 574

  Fly   872 IITGAVLVPTICILCVV-TYICRQK----QKAKK---ETVKMTMALSGCE---DSEPLRPSNIGA 925
            ||....:..||.::.:| .:|..::    .||.:   |.:.......|.:   |.|.....|...
Zfish   575 IIAVVAVAGTIILVFMVFGFIIGRRHCGYSKADQEGDEELYFQFKFPGTKTYIDPETYEDPNRAV 639

  Fly   926 NLCKLRIVKDAE---LRKGGVLGMGAFGRVYKGVWVPEGENVKIP------VAIKELLKSTGAES 981
            :    :..|:.:   ::...|:|.|.||.|..|       .:|:|      ||||.|......:.
Zfish   640 H----QFAKELDASCIKIERVIGAGEFGEVCSG-------RLKLPGKRDVSVAIKTLKVGYTEKQ 693

  Fly   982 SEEFLREAYIMASVEHVNLLKLLAVCMSSQ-MMLITQLMPLGCLLDYVRNNRDKIGSKALLNWST 1045
            ..:||.||.||...:|.|::.|..|....: :|::.:.|..|.|..::|.:..:.....|:....
Zfish   694 RRDFLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEYMENGSLDAFLRKHDGQFTVIQLVGMLR 758

  Fly  1046 QIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNE-YKAAGGKMPIKWLAL 1109
            .||.||.||.:...|||||||||:||.:..:.|::||||::::..|... |...|||:|::|.|:
Zfish   759 GIAAGMRYLSDMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIDDDPEAVYTTTGGKIPVRWTAM 823

  Fly  1110 ECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLL 1174
            |.|:.|.|||.||||::|:.:||::::|:||:.::..:|:...||.|.:|..|..|...::..:|
Zfish   824 EAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDCPPGLHQLML 888

  Fly  1175 SCWHLDAAMRPTFKQLTTVFAEFARDP 1201
            .||..|.|.||.|.|:..:..:..|:|
Zfish   889 DCWQKDRADRPKFDQIVGILDKMIRNP 915

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EgfrNP_476759.1 Recep_L_domain 128..239 CDD:460032
Furin-like 253..401 CDD:395614
Recep_L_domain 419..547 CDD:460032 15/98 (15%)
GF_recep_IV 572..684 CDD:464344 25/134 (19%)
FU 662..716 CDD:214589 12/65 (18%)
GF_recep_IV 740..>834 CDD:464344 20/135 (15%)
PTKc_EGFR_like 930..1208 CDD:270648 95/283 (34%)
epha7NP_001038444.2 EphR_LBD_A7 29..205 CDD:198453 19/118 (16%)
FN3 <313..>543 CDD:442628 39/293 (13%)
FN3 464..555 CDD:238020 6/90 (7%)
EphA2_TM 583..648 CDD:464211 12/68 (18%)
PTKc_EphR_A 646..912 CDD:270651 92/272 (34%)
SAM_EPH-A7 937..1006 CDD:188947
Blue background indicates that the domain is not in the aligned region.

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