Protein Alignment Egfr and ror2

DIOPT Version :10

• Sequence 1: NP_476759.1
• Gene: Egfr / 37455
• FlyBaseID: FBgn0003731
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: XP_021327888.1
• Gene: ror2 / 561183
• ZFINID: ZDB-GENE-060427-5
• Length: 939
• Species: Danio rerio
• Alignment Length: 752
• Identity: 179/752 - (23%)
• Similarity: 285/752 - (37%)
• Gaps: 208/752 - (27%)

  Fly   737 CRKCHPLCELCTNYGYHEQVCSKCTHYKRREQCET----ECPADHYTDEEQRECFQCH---PECN 794
            |....||||..|......|:|        |::||.    .|.|: ||...........   |.|:
Zfish   233 CYYVFPLCEEGTRGPRRRQLC--------RDECEALENDLCNAE-YTIARSNPLILMQLELPVCS 288

  Fly   795 GCTGPGADDCKSCRNFKLFDA---------NETGPYVNSTM------FNC---TSKCPLEMRHVN 841
            ....||:.|..||....|...         ||:|.....|:      |.|   :::.| ...|::
Zfish   289 LLPHPGSPDASSCIRIGLPPQYSPPDHSCYNESGGNYKGTVSVTKSGFQCQPWSAQYP-HSHHLS 352

  Fly   842 -YQYTAI---------------GPYC---------------AASPPRSSKITANLDVNMIFIITG 875
             .:|..:               .|:|               ..:||...|      ..:::|:..
Zfish   353 PIEYPQLRGGHNFCRNPGGQMESPWCFTLDPNVRVDLCDIPPCNPPEKMK------KELLYILIP 411

  Fly   876 AVLVPTI--CILCVVTYICRQKQKAKKET-VKMTMALSGCEDSE-PLRPSNIGANLCKLRIVKDA 936
            :|..|.:  |:..::. :||.|||...:| .:..:..|..::.| ||  .|...:..|||.:..:
Zfish   412 SVATPLVFACLFFLIC-MCRNKQKESVDTPTRRQLTASPSQEMELPL--LNQHKHQAKLRELNLS 473

  Fly   937 ELRKGGVLGMGAFGRVYKG--VWVPEGENVKIPVAIKELLKSTGAESSEEFLREAYIMASVEHVN 999
            .:|....||...||:||||  .....||..:: ||||.:.........|||..||.:.:.::|.|
Zfish   474 AVRFMEELGEDRFGKVYKGHLYGTAPGEQTQV-VAIKTVKDKDEGPLREEFRHEAMLRSRLQHPN 537

  Fly  1000 LLKLLAVCMSSQMMLITQLMPLGCLLDY-----------VRNNRDKIGS-------KALLNWS-- 1044
            ::.||.|        ||:..|:..:..|           :|:....:||       |:.|..:
Zfish   538 IVCLLGV--------ITKEQPMSMIFSYSGQGDLHEFLVMRSPHSDVGSSDDDKTVKSTLEQADF 594

  Fly  1045 ----TQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAGGK-MPI 1104
                ||:|.||.||....:||:||||||:||.....|||.|.||.:.:.| ::.||..|.. .||
Zfish   595 LHIVTQVAAGMEYLSSHHVVHKDLAARNILVCDKLNVKILDLGLFREVYS-ADYYKLMGASPFPI 658

  Fly  1105 KWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDI 1169
            :|::.|.|....|::.||:|::||.:||:.::|.:|:.....:|:.:::.....|..|:.|...|
Zfish   659 RWMSPEAILYGKFSTDSDIWSYGVVLWEIFSYGLQPYCGYSNQDVIEMVRNRQVLSCPDDCPAWI 723

  Fly  1170 YCTLLSCWHLDAAMRPTFKQL------------------------TTVFAEFARDP------GRY 1204
            |..:|.||:...:.||.||.:                        ||..:..:..|      .||
Zfish   724 YTMMLECWNEFPSRRPRFKDIHARLRTWESLSNYNSSAQTSGASNTTQTSSLSTSPVSNISNARY 788

  Fly  1205 ----------------------------LAIPGDKFTRLPAY----------------TSQDEKD 1225
                                        |.||.:.:..:|||                ..|....
Zfish   789 VSPKKSSPFPQPQFVSMKGQMRPMVPPQLYIPVNGYQPMPAYPYLQNFYPMQIPMQMPPQQMHPQ 853

  Fly  1226 LIRKLAPTTDGSEAIAEPDDYLQPKAAPGPSHRTDCTDEIPKLNRYCKDPSNKNSSTGDDETDSS 1290
            ::.|......||.:.:.......|....|       ||::..:|...|       :|.||..|.:
Zfish   854 MVAKAGSHHSGSGSTSTGYVTTAPSNGSG-------TDKVALMNEDLK-------ATEDDFADGA 904

  Fly  1291 AREVGVGNLRLDLPVDEDDYLMPTCQPGPNNNNNINN 1327
            :::   |....||.|.|.:.|.....| ...:|.||:
Zfish   905 SQK---GLHHEDLSVPETELLGDNDSP-HTEDNEINS 937

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Egfr	NP_476759.1	Recep_L_domain	128..239	CDD:460032
		Furin-like	253..401	CDD:395614
		Recep_L_domain	419..547	CDD:460032
		GF_recep_IV	572..684	CDD:464344
		FU	662..716	CDD:214589
		GF_recep_IV	740..>834	CDD:464344	28/118 (24%)
		PTKc_EGFR_like	930..1208	CDD:270648	97/362 (27%)
ror2	XP_021327888.1	I-set	63..152	CDD:400151
		Ig strand B	79..83	CDD:409353
		Ig strand C	92..96	CDD:409353
		Ig strand E	118..122	CDD:409353
		Ig strand F	132..137	CDD:409353
		Ig strand G	145..148	CDD:409353
		CRD_FZ	171..307	CDD:470581	22/82 (27%)
		KR	314..395	CDD:238056	11/81 (14%)
		PTKc_Ror2	468..751	CDD:270673	90/292 (31%)