DRSC/TRiP Functional Genomics Resources

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Protein Alignment Egfr and ryk

DIOPT Version :9

Sequence 1:NP_476759.1 Gene:Egfr / 37455 FlyBaseID:FBgn0003731 Length:1426 Species:Drosophila melanogaster
Sequence 2:XP_005165988.1 Gene:ryk / 558502 ZFINID:ZDB-GENE-070209-277 Length:632 Species:Danio rerio


Alignment Length:646 Identity:157/646 - (24%)
Similarity:251/646 - (38%) Gaps:163/646 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   670 ATCDGCTGPKDTIGIGACTTCNLAIINNDATVKRCLLKD-------DKCPDGYFWEYVHPQEQGS 727
            |.|  ...|.::.||......|:.|..::..||:.|..|       |...:.|...:|.|     
Zfish    40 ARC--LANPSNSPGINNNNRPNVNIFMSEEEVKKLLGLDAELYYVRDDVVNHYALSFVLP----- 97

  Fly   728 LKPLAGRAVCRKCHPLCELCTNYGYHEQVCSKCTHYKRREQCETECPADHYTDEEQRECFQCHPE 792
             .|....::....|...::....|:|.:..|.....:.....:.|.|       ..|..|:....
Zfish    98 -VPSDTNSLHFTWHSSSKVDYRLGFHVENTSAMDQPQSNISVQGEVP-------RTRSVFRVDLF 154

  Fly   793 CNGCTGPGAD---------DCKSCRNFKLFDANETGPYVNSTMFNCTSKC------PLEMRHVNY 842
            |:|    .||         :..:..||.:.:            |.....|      |...:.:.:
Zfish   155 CSG----KADGEAVLTVQLNLSTAANFTVLN------------FKRRKMCYRRIEQPEPPKTLPF 203

  Fly   843 QYTAIGPYCAASP--PRSSKITANLDVNMIFIITGAVLVPTICILCVVTYICR------------ 893
            ..|.|....|:||  |.:|        ..:|.|       ::|:.|:|.::..            
Zfish   204 PNTTIQRIDASSPNAPTTS--------TRVFYI-------SVCVCCIVIFLVAIILAVLHLHSMK 253

  Fly   894 ------------QKQKAKKETVKMT------------------------MALSGCEDSEPLRPSN 922
                        ..|...:.:.:.|                        :.|:|.....|..||:
Zfish   254 RVEMDDSVSDSGSSQGLSQPSTQTTQYLRADTPNNATPVTNAQTGSAPMLQLAGASFPHPGAPSH 318

  Fly   923 IGANLCKLRI----------------VKDAELRK-----GGVLGMGAFGRVYKGVWVPEGENVKI 966
            ...:...|||                |||..:.:     ..||..|.|||::.||.:.|    |.
Zfish   319 ETKSYPSLRIEKNDLRSVTLLEAKAKVKDIAISRERVTLRDVLHEGTFGRIFHGVLLDE----KD 379

  Fly   967 PVAIKEL-LKSTGAESSE----EFLREAYIMASVEHVNLLKLLAVCM--SSQMMLITQLMPLGCL 1024
            |...|:: :|:....:||    ..|.|:..:..:.|.|||.:..||:  ..:.|::...|..|.|
Zfish   380 PSKEKQVFVKAVKDHASEVQVTMMLTESCKLRGLHHRNLLPISHVCIEDGEKPMVLLPYMNWGNL 444

  Fly  1025 LDYVR-------NNRDKIGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDF 1082
            ..::|       ||...|..:.|::.:.||:.|||||..:.::|:||||||.::.....|||||.
Zfish   445 KLFLRQCKLAEANNPQAISQQDLVHMAIQISCGMSYLARREVIHKDLAARNCVIDNSMQVKITDN 509

  Fly  1083 GLAK-LLSSDSNEYKAAGG--KMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENI 1144
            .||: |...|   |...|.  ..|::|:|||.:.|..|:|.|||||||||:|||:|.||.|:.:|
Zfish   510 ALARDLFPMD---YHCLGDNENRPVRWMALESLLNNDFSSASDVWAFGVTLWELMTLGQTPYVDI 571

  Fly  1145 PAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARDPGRYL 1205
            ...::...::.|.::.||..|..:::..:..||.||...||.|:||.....||....|.|:
Zfish   572 DPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLTEFHAALGAYV 632

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EgfrNP_476759.1 Recep_L_domain 419..547 CDD:279382
GF_recep_IV 572..684 CDD:291509 3/13 (23%)
FU 573..>606 CDD:238021
FU 617..659 CDD:214589
FU 662..716 CDD:214589 12/52 (23%)
FU 739..786 CDD:238021 7/46 (15%)
FU 784..834 CDD:214589 10/64 (16%)
PTKc_EGFR_like 930..1208 CDD:270648 105/314 (33%)
STYKc 938..1194 CDD:214568 95/277 (34%)
Recep_L_domain 128..239 CDD:279382
Furin-like 253..401 CDD:279142
FU 255..292 CDD:214589
FU 302..345 CDD:238021
rykXP_005165988.1 WIF 70..184 CDD:280237 23/142 (16%)
PTK_Ryk 348..628 CDD:270639 97/286 (34%)
Pkinase_Tyr 355..621 CDD:285015 95/272 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1025
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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