DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Egfr and kdr

DIOPT Version :10

Sequence 1:NP_476759.1 Gene:Egfr / 37455 FlyBaseID:FBgn0003731 Length:1426 Species:Drosophila melanogaster
Sequence 2:NP_001019824.2 Gene:kdr / 554230 ZFINID:ZDB-GENE-041001-112 Length:1357 Species:Danio rerio


Alignment Length:838 Identity:193/838 - (23%)
Similarity:298/838 - (35%) Gaps:298/838 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   645 RDGQHCVSECPKNKYNDRGVCRECH-------ATCDGCTG---------------------PKDT 681
            |..|..|::.|:....|..:.|:.|       .||.|..|                     ||..
Zfish   423 RTFQLVVNDLPRIFEKDVSLDRDVHMYGSSPTLTCTGSGGSSPVTIKWQWMPREDCPVRFLPKSD 487

  Fly   682 IGIGAC--------TTCNLAIINNDATVKRCL-----LKDDKCPDGYFWEYVHPQEQG------- 726
            ..:..|        .|....:|:..:..:|.|     ||..|..|...:..:...:.|       
Zfish   488 PSMAKCDKWREMSNNTGKNPLISQTSVDERTLKTISTLKIQKAVDHALYRCIATNKMGQDQRVIV 552

  Fly   727 -------------SLKPLAGRAVCRKCHPLCELCTNYGYHEQVCSKCTHYKRR------------ 766
                         |..|:.|:.|..:|               |..:..:|..|            
Zfish   553 FQVTRFLNLSVLPSSSPIEGQDVIMRC---------------VADRLLYYNLRWYRVANVANHDP 602

  Fly   767 ----EQCET-----------------------ECPADHYTDEEQRECFQCHPECNGCTGPGADDC 804
                ..|:|                       :.|..:.|..:| ..:.|..|..|...      
Zfish   603 PPAAVPCDTLTLSHLHQPNVTVSGLQGTNVTLDMPIPNATMMDQ-GLYACQVEIVGTNE------ 660

  Fly   805 KSC--RNFKL-------FDANETGPYVN---STMFNC-TSKCP---------------------- 834
            |:|  .|.:|       ...|.|...||   ||...| .|..|                      
Zfish   661 KTCLLHNLRLRALEMSRIVTNLTDQRVNVSDSTTLVCEVSGTPTPTIVWTKDNQTVMEGSGVILK 725

  Fly   835 -----LEMRHVN------YQYTAIGPY-CAASPPRSSKITANLDVNMIFII-TGAVLVPTICILC 886
                 |.::.|.      |..||.... |.:|..|.|...|...:|:..|: .|||::.....|.
Zfish   726 RSNRVLTIQRVKKEDSGLYICTACNQQGCESSEARISVDGAEEKMNVELIMPIGAVVIAMFLWLL 790

  Fly   887 VVTYICRQKQKAKKETVKMTMALSGCEDSEPLRPSNIGANLCKLRIVKDA--------ELRKGGV 943
            :| ::.|.:::.....:| |..||...||:.: |.:   ..|: |:..||        .|:.|..
Zfish   791 IV-FVIRNRKRPNDGDLK-TGYLSIILDSDDM-PMD---EHCE-RLTYDASKWEFPRDRLKLGEP 848

  Fly   944 LGMGAFGRVYK----GVWVPEGENVKIPVAIKELLKSTGAESSE--EFLREAYIMASV-EHVNLL 1001
            ||.||||:|.:    |:   |.......||:| :||. ||.|||  ..:.|..|:..: .|:|::
Zfish   849 LGRGAFGQVVEATAYGI---EKATTCTTVAVK-MLKE-GATSSEYRALMSELKILIHIGHHLNVV 908

  Fly  1002 KLLAVC--MSSQMMLITQLMPLGCLLDYVRNNR-------------------------------- 1032
            .||..|  ....:|:|.:....|.|..|:::.|                                
Zfish   909 NLLGACTKQGGPLMVIVEYCKHGNLSSYLKSKRGEYSPYKKRTPRMPNRREVQQDEDPREGDLGL 973

  Fly  1033 -----------------------------------DKIGSKALLNWSTQIAKGMSYLEEKRLVHR 1062
                                               |.:..:.|:::|.|:||||.:|..::.:||
Zfish   974 GTSTRLDICTGTAVCTRTGEQTSTTLQDEQESSDWDHLTMEDLISYSFQVAKGMEFLASRKCIHR 1038

  Fly  1063 DLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFG 1127
            ||||||:|:...|:|||.|||||:.:..|.:..:....::|:||:|.|.|.:||:|::||||:||
Zfish  1039 DLAARNILLSENSVVKICDFGLARDVYKDPDYVRKGDARLPLKWMAPETIFDRVYTTQSDVWSFG 1103

  Fly  1128 VTIWELLTFGQRPHENIPAKDIPD----LIEVGLKLEQPEICSLDIYCTLLSCWHLDAAM-RPTF 1187
            |.:||:.:.|..|:   |...|.:    .::.|.::..|:..:.:||.|:|.|| ||..: ||||
Zfish  1104 VLLWEIFSLGASPY---PGVCIDESFCRRLKEGTRMRAPDYATPEIYQTMLDCW-LDRPLDRPTF 1164

  Fly  1188 KQLTTVFAEFARDPGRYLAIPGDKFTRLPAYTSQDEKDLIRKLAPTTDG--SEAIAEP 1243
            .||.......                 |.|...||.||.|    |.|:|  .|.:..|
Zfish  1165 TQLVEHLGNL-----------------LQASAQQDGKDYI----PLTNGEMEEELVAP 1201

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EgfrNP_476759.1 Recep_L_domain 128..239 CDD:460032
Furin-like 253..401 CDD:395614
Recep_L_domain 419..547 CDD:460032
GF_recep_IV 572..684 CDD:464344 13/66 (20%)
FU 662..716 CDD:214589 17/94 (18%)
GF_recep_IV 740..>834 CDD:464344 24/145 (17%)
PTKc_EGFR_like 930..1208 CDD:270648 103/366 (28%)
kdrNP_001019824.2 Ig 227..333 CDD:472250
Ig strand B 244..248 CDD:409448
Ig strand C 259..263 CDD:409448
Ig strand E 297..301 CDD:409448
Ig strand F 311..316 CDD:409448
Ig strand G 324..327 CDD:409448
Ig 336..429 CDD:472250 2/5 (40%)
Ig strand B 356..360 CDD:409353
Ig strand C 369..373 CDD:409353
Ig strand E 393..397 CDD:409353
Ig strand F 407..412 CDD:409353
Ig strand G 422..425 CDD:409353 1/1 (100%)
IG_like 571..654 CDD:214653 12/98 (12%)
I-set 677..763 CDD:400151 17/85 (20%)
Ig strand B 694..697 CDD:409353 0/2 (0%)
Ig strand C 706..710 CDD:409353 0/3 (0%)
Ig strand E 729..733 CDD:409353 1/3 (33%)
Ig strand F 743..748 CDD:409353 1/4 (25%)
VEGFR-2_TMD 768..802 CDD:375470 8/34 (24%)
Protein Kinases, catalytic domain 835..1178 CDD:473864 101/368 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 944..975 0/30 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1296..1357
Blue background indicates that the domain is not in the aligned region.

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