DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Egfr and erbb3b

DIOPT Version :9

Sequence 1:	NP_476759.1	Gene:	Egfr / 37455	FlyBaseID:	FBgn0003731	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_001014826.1	Gene:	erbb3b / 544664	ZFINID:	ZDB-GENE-050107-1	Length:	1429	Species:	Danio rerio

Alignment Length:	1443	Identity:	454/1443 - (31%)
Similarity:	653/1443 - (45%)	Gaps:	353/1443 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 KICIGTKSRLSVPSNKEHHYRNLRDRYTNCTYVDGNLELTWLPNENLDLSFLDNIREVTGYILIS 164
            ::|.|||:.||.....|.||.||::|||.|..|.||||:|.:.|: ||.|||.:||||||||||:
Zfish    26 EVCTGTKNALSSTGTPEQHYNNLKERYTGCEIVMGNLEITQMEND-LDFSFLGSIREVTGYILIA 89

  Fly   165 HVDVKKVVFPKLQIIRGRTLFSLSVEEEKYAL-----FVTYSKMYTLEIPDLRDVLNGQVGFHNN 224
            ....:|:...:|::|||.:|:     ::::||     |.|::.:..|.:.:|.::|.|.|...:|
Zfish    90 MNQFRKLPLNQLRVIRGSSLY-----DKEWALSVFHNFDTHTGLEDLGLTNLTEILEGGVQIVHN 149

  Fly   225 YNLCHMRTIQWSEIVSNGTDAYYNYDFTAPEREC-PKCHESCTHGCWGEGPKNCQKFSKLTCSPQ 288
            .||.:...|.|.:||.:| ||............| |.|.|.    |||.....|||.:|..|:.|
Zfish   150 RNLSYAPLINWQDIVRDG-DARIQIQDNGGRGSCNPACGEF----CWGPSNDQCQKLTKTVCALQ 209

  Fly   289 CAGGRCYGPKPRECCHLFCAGGCTGPTQKDCIACKNFFDEGVCKEECPPMRKYNPTTYVLETNPE 353
            |. |.|:|..|.||||..||||||||...||.||::....|.|...||....||..|:.:|.|.:
Zfish   210 CL-GHCFGTNPNECCHPECAGGCTGPRDTDCFACRHVNYSGSCVPHCPWPVVYNQQTFQVEPNAD 273

  Fly   354 GKYAYGATCVKECPGHLLRDNGACVRSCPQDK--MDKG--GECVPCNGPCPKTCPGVTVLH---- 410
            ..|.:|:.||.:||||.:.|..|||.|||..|  ::|.  .:|..|.|.|||.|.|....|
Zfish   274 AMYQFGSICVPKCPGHFVVDGSACVSSCPPGKTEIEKNQIKQCETCIGLCPKVCEGTGANHRQTV 338

  Fly   411 -AGNIDSFRNCTVIDGNIRILDQTFSGFQDVYANYTMGPRYIPLDPERLEVFSTVKEITGYLNIE 474
             :.|||||.|||.|.|::..|.....|  |||.|..      ||:||:|:||:||:||||.|||:
Zfish   339 DSSNIDSFINCTKIQGSLHFLILGIKG--DVYNNIP------PLEPEKLKVFNTVREITGILNIQ 395

  Fly   475 GTHPQFRNLSYFRNLETIHGRQLM--ESMFAALAIVKSSLYSLEMRNLKQISSGSVVIQHNRDLC 537
            ....:..:||.|.:|.||.||.|.  .:.|:.|.:...||.||.:|::::||.|||.|..|.:||
Zfish   396 SWPDELHDLSVFSSLTTIQGRSLYNPNTPFSMLMMKIPSLTSLGLRSMREISDGSVYITQNMNLC 460

  Fly   538 YVSNIRWPAI---QKEPEQKVWVNENLRADLCEKNGTICSDQCNEDGCWGAGTDQCLTCKNFNFN 599
            |...|.|..|   .:...::..:.||.:...||:.|.:|...|::.||||.|.:|||:|:|::..
Zfish   461 YHHTINWTQIFPRNQLQRRRNDIKENKQKIQCEEEGHVCDPLCSDAGCWGPGPEQCLSCRNYSRL 525

  Fly   600 GTCIADCGYIS---NAYKFDNRTCKICHPEC------RTCNGAGADHCQECVHVRDGQHCVSECP 655
            |||::.|...|   ..:...|:.|..||.||      :||.|.|||.|..|.::.||.||||.||
Zfish   526 GTCVSHCNLYSGEPREFAASNKECLACHSECLLQNGKQTCLGKGADQCVACSNLMDGPHCVSSCP 590

  Fly   656 KNKYNDRGVCRECHATCDGCTGPKDTIGIGACTTCNLAIINNDATVKRCLLKDDKCPDGYFWEYV 720
            .....::|.....::|..|
Zfish   591 NGVNGEKGQTIFKYSTAAG---------------------------------------------- 609

  Fly   721 HPQEQGSLKPLAGRAVCRKCHPLCELCTNYGYHEQVCSKCTHYKRREQCETECPADHYTDEEQRE 785
                                |  ||||                             |
Zfish   610 --------------------H--CELC-----------------------------H-------- 615

  Fly   786 CFQCHPECNGCTGPGADDCKSCRNFKLFDANETGPYVNSTMFNCTSKCPLEMRHVNYQYTAIGPY 850
             |.|   ..|||||...||...      |.|     |||:                 |...|
Zfish   616 -FNC---TRGCTGPALRDCVDP------DRN-----VNSS-----------------QIAGI--- 645

  Fly   851 CAASPPRSSKITANLDVNMIFIITGAVLVPTICILCVVTYICRQKQKAKKETVKMTMALSGCEDS 915
                   :..:.|.:.|.:...:.|.:....:.|        |:|:..::       .|...|..
Zfish   646 -------AVAVFAGITVLLALFVLGMLYHRGLAI--------RRKRALRR-------YLESGESM 688

  Fly   916 EPLRPSNIGANLCKLRIVKDAELRKGGVLGMGAFGRVYKGVWVPEGENVKIPVAIKELLKSTGAE 980
            |||.|...|..: ..||:|..|||||.:||.|.||.|.||.|:|||:::|||||||.:...:..:
Zfish   689 EPLDPGEKGTKV-HARILKPQELRKGKLLGYGVFGTVNKGFWIPEGDSLKIPVAIKTIQNRSSRQ 752

  Fly   981 SSEEFLREAYIMASVEHVNLLKLLAVCMSSQMMLITQLMPLGCLLDYVRNNRDKIGSKALLNWST 1045
            :..|.......|.|::|..:::|:.:|..:.:.|||||.|.|.||.::|.::|.:..:.||||..
Zfish   753 TFTEITDHMLSMGSLDHPYIVRLIGICPGASLQLITQLSPHGSLLQHLRQHKDSLDPQRLLNWCV 817

  Fly  1046 QIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAGGKMPIKWLALE 1110
            ||||||.||||..:.||:|||||:|:::..:|:|:|||:|.||..|..:|..:..|..|||:|||
Zfish   818 QIAKGMYYLEEHCMAHRNLAARNILLKSDYIVQISDFGVADLLYPDDKKYVYSEHKTSIKWMALE 882

  Fly  1111 CIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLS 1175
            .|....:|.:||||::|||:||::::|..|:.::...|:|.|:|.|.:|.||:||::|:|..::.
Zfish   883 SILFGRYTHQSDVWSYGVTVWEMMSYGAEPYASMHPHDVPGLLEKGERLAQPQICTIDVYMVMVK 947

  Fly  1176 CWHLDAAMRPTFKQLTTVFAEFARDPGRYLAI-PGD------------KFTRLPAYTSQDEKDLI 1227
            ||.:|..:|||||:|.:.|...||||.|||.: |..            |.:.|.....:::.|..
Zfish   948 CWMIDENVRPTFKELASEFTRMARDPPRYLVVRPAQNGGGAEESQRYVKSSHLEVGLEEEDDDED 1012

  Fly  1228 R-----------KLAPTTDGSEA-IAE---------PDDYLQPKAAPGPSHRTDCTDEIPKLNRY 1271
            .           :|:||...|.. ||.         |..||  ...|||.      ||..:|..
Zfish  1013 EGLQVGFATPPLQLSPTRSHSRVRIASYKSTSEHTAPIGYL--PMTPGPG------DEPRQLRA- 1068

  Fly  1272 CKDPSNKNSSTGDDETDSSARE-----VGV--------------GNLRLDLP------------- 1304
                  :...||...|:|...|     |.:              |..|:|..
Zfish  1069 ------QRRKTGSVRTESECSEGRGTIVDIEAVEITSQTGSLRRGRSRMDSAYISGGVSVASDPF 1127

  Fly  1305 ------VDED--DYLMPT-------CQPGPNNNNNINNPNQNNMAAVGVAAGYMDLIGVPVSVDN 1354
                  ||||  .|::||       ...|..:.|:.:.|..:                     ..
Zfish  1128 SSGLEGVDEDHYGYVLPTERDFRSAVPHGRTSRNSKSTPKTD---------------------AT 1171

  Fly  1355 PEY-LLNAQTLGVGESPI-------PTQTIGIPVMGVPGTMEVKVPMPGSEPTSSDHEYYNDTQR 1411
            .|| |:|.||..:..||.       |...:...:.   .::..|..|..::           ||.
Zfish  1172 QEYELMNKQTNKLSSSPTDSTDHLKPASLVSAHIC---SSLPQKKEMDSAQ-----------TQD 1222

  Fly  1412 ELQPLHRNRNTET 1424
            |:.|  :.|.|::
Zfish  1223 EILP--QKRETDS 1233

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Egfr	NP_476759.1	Recep_L_domain	419..547	CDD:279382	55/129 (43%)
		GF_recep_IV	572..684	CDD:291509	42/120 (35%)
		FU	573..>606	CDD:238021	15/32 (47%)
		FU	617..659	CDD:214589	22/47 (47%)
		FU	662..716	CDD:214589	3/53 (6%)
		FU	739..786	CDD:238021	6/46 (13%)
		FU	784..834	CDD:214589	14/49 (29%)
		PTKc_EGFR_like	930..1208	CDD:270648	125/278 (45%)
		STYKc	938..1194	CDD:214568	113/255 (44%)
		Recep_L_domain	128..239	CDD:279382	43/115 (37%)
		Furin-like	253..401	CDD:279142	64/152 (42%)
		FU	255..292	CDD:214589	14/37 (38%)
		FU	302..345	CDD:238021	21/42 (50%)
erbb3b	NP_001014826.1	Recep_L_domain	54..164	CDD:279382	43/115 (37%)
		Furin-like	176..325	CDD:279142	64/153 (42%)
		FU	222..267	CDD:238021	22/44 (50%)
		Recep_L_domain	348..471	CDD:279382	55/130 (42%)
		GF_recep_IV	498..630	CDD:291509	55/240 (23%)
		FU	499..>532	CDD:238021	15/32 (47%)
		FU	546..592	CDD:214589	22/45 (49%)
		TM_ErbB3	639..677	CDD:213056	9/72 (13%)
		PTK_HER3	702..980	CDD:173656	125/277 (45%)
		Pkinase_Tyr	710..966	CDD:285015	113/255 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	108	1.000	Domainoid score	I6356
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H25007
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45861
OrthoDB	1	1.010	-	-		D51516at33208
OrthoFinder	1	1.000	-	-		FOG0000755
OrthoInspector	1	1.000	-	-		otm25049
orthoMCL	1	0.900	-	-		OOG6_101159
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X448
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.930