Protein Alignment Egfr and Flt1

DIOPT Version :10

• Sequence 1: NP_476759.1
• Gene: Egfr / 37455
• FlyBaseID: FBgn0003731
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: NP_062179.2
• Gene: Flt1 / 54251
• RGDID: 2621
• Length: 1336
• Species: Rattus norvegicus
• Alignment Length: 1053
• Identity: 221/1053 - (20%)
• Similarity: 357/1053 - (33%)
• Gaps: 363/1053 - (34%)

  Fly   496 QLMESMFAALAI-VKSSLY-----SLEMRNLKQISSGSVVIQHNRDLCYVSNIRWPAIQKEPEQK 554
            :|..::.|.|.: ||..:|     ||....|..:.|..|:      .|.|..|..|.|:
  Rat   413 KLFRNLTATLIVNVKPQIYEKSVSSLPSPPLYPLGSRQVL------TCTVYGIPQPTIK------ 465

  Fly   555 VWVNENLRADLCEKNGTICSDQCNEDGCWGA---------------------------GTDQCL- 591
             |:...     |..|.   |.:.| |.|:|:                           ||::.:
  Rat   466 -WLWHP-----CHYNH---SKERN-DFCFGSEESFILDSSSNIGNRIEGITQRMMVIEGTNKTVS 520

  Fly   592 -------------TCKNFNFNGTCIADCGY----ISNAYKFDNRTCKICHPECRTCNGAGADHCQ 639
                         :||.||..||...|..:    :.|.:          |.........|.|...
  Rat   521 TLVVADSRTPGIYSCKAFNKIGTVERDIRFYVTDVPNGF----------HVSLEKIPTEGEDLKL 575

  Fly   640 ECV----HVRDGQHCVSECPKNKYNDRGVCRECHATCDGCTGPKDTIGIGACTTCNLAIIN---N 697
            .||    ..||....:.....|:.....:.::..||....:           .|.||.|.|   .
  Rat   576 SCVVSKFLYRDITWILLRTVNNRTMHHSISKQKMATTQDYS-----------ITLNLVIKNVSLE 629

  Fly   698 DATVKRCLLKDDKCPDGYFWEYVHPQEQGSLKPLAGRAVCRKCHPLCE------LCTNYGYHEQV 756
            |:....|..::                     ...|..:.||...|..      |..|...||..
  Rat   630 DSGTYACRARN---------------------IYTGEEILRKTEVLVRDLEAPLLLQNLSDHEVS 673

  Fly   757 CSKCTHYKRREQCETE-CPADHYTDEEQRECFQCHPECNGCTGPGADDCKSCRNFKLFDANETGP 820
            .|..|..    .|:.. .||...|..:.....|..|..  ..|||
  Rat   674 ISGSTTL----DCQARGVPAPQITWFKNNHKIQQEPGI--ILGPG-------------------- 712

  Fly   821 YVNSTMFNCTSKCPLEMRHVNYQYTAIGPY-CAASPPR-----SSKIT-------ANLDVNMIFI 872
              |||:|         :..|..:..  |.| |.|:..:     |:.:|       :||:   :..
  Rat   713 --NSTLF---------IERVTEEDE--GVYRCRATNQKGVVESSAYLTVQGTSDKSNLE---LIT 761

  Fly   873 ITGAVLVPTICILCVVTYICRQKQKAKKETVKMTMALSGCEDSEPLRPSNIGANLCKLRIVKDA- 936
            :|...:..|:..|.:..:| |:.:::..|.....:::....|..||...      |: |:..||
  Rat   762 LTCTCVAATLFWLLLTLFI-RKLKRSSSEVKTDYLSIIMDPDEVPLDEQ------CE-RLPYDAS 818

  Fly   937 -------ELRKGGVLGMGAFGRVYK----GVWVPEGENVKIP----VAIKELLKSTGAESSEEFL 986
                   .|:.|..||.||||:|.:    |:       .|.|    ||:|.|.:...|...:..:
  Rat   819 KWEFARERLKLGKSLGRGAFGKVVQASAFGI-------KKSPTCRTVAVKMLKEGATASEYKALM 876

  Fly   987 REAYIMASV-EHVNLLKLLAVC--MSSQMMLITQLMPLGCLLDYVRNNRD--------------- 1033
            .|..|:..: .|:|::.||..|  ....:|:|.:....|.|.:|:::.||
  Rat   877 TELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDFFCLNKDAALHMEPK 941

  Fly  1034 ---------------------------------------------------KIGSKALLNWSTQI 1047
                                                               .:..:.|:::|.|:
  Rat   942 KEKLEPDLEQDQKPRLDSVSSSESFTSSGFQEDKSVSDVEGGEDYSEISKQPLTMEDLISYSFQV 1006

  Fly  1048 AKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAGGKMPIKWLALECI 1112
            |:||.:|..::.:||||||||:|:...::|||.|||||:.:..:.:..:....::|:||:|.|.|
  Rat  1007 ARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRRGDTRLPLKWMAPESI 1071

  Fly  1113 RNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPA-KDIPDLIEVGLKLEQPEICSLDIYCTLLSC 1176
            .::|:::|||||::||.:||:.:.|..|:..:.. :|....::.|:::..||..:.:||..:|.|
  Rat  1072 FDKVYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLKEGMRMRTPEYATPEIYQIMLDC 1136

  Fly  1177 WHLDAAMRPTFKQLTTVFAEFARDPGRYLAIPGDKFTRLPAYTSQDEKDLIRKLAPTTDGS---- 1237
            ||.|...||.|.:|.....:.                 |.|...||.||.|...|..|..|
  Rat  1137 WHKDPKERPRFAELVEKLGDL-----------------LQANVQQDGKDYIPLNAILTRNSGFTY 1184

  Fly  1238 --EAIAE---PDDYLQPKAAPGPS--------------HRTDCTDEI------------------ 1265
              ...:|   .|.:..||...|.|              .|....:|:
  Rat  1185 SVPTFSEDFFKDGFTDPKFHSGSSDDVRYVNAFKFMSLERIKTFEELSPNATSMFEDYHLDTSSL 1249

  Fly  1266 ---PKLNRYC-KDPSNKNSSTGDDETDSSAREVGV-------------GNLRLDLPVDEDDYLM- 1312
               |.|.|:. .:...|.|...|....|.::|.|:             |::|.....||||..:
  Rat  1250 LTSPLLKRFTWTETKPKASMKIDLRITSKSKEAGLSDLPGPSFCFSSCGHIRPVRQEDEDDPELG 1314

  Fly  1313 --PTCQPGPNNNN 1323
              ..|.|.|:.|:
  Rat  1315 KESCCSPPPDYNS 1327

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Egfr	NP_476759.1	Recep_L_domain	128..239	CDD:460032
		Furin-like	253..401	CDD:395614
		Recep_L_domain	419..547	CDD:460032	15/56 (27%)
		GF_recep_IV	572..684	CDD:464344	25/160 (16%)
		FU	662..716	CDD:214589	9/56 (16%)
		GF_recep_IV	740..>834	CDD:464344	20/100 (20%)
		PTKc_EGFR_like	930..1208	CDD:270648	91/363 (25%)
Flt1	NP_062179.2	IG_like	143..219	CDD:214653
		Ig	231..330	CDD:472250
		Ig strand B	248..252	CDD:409353
		Ig strand C	263..267	CDD:409353
		Ig strand E	294..298	CDD:409353
		Ig strand F	308..313	CDD:409353
		Ig strand G	321..324	CDD:409353
		Ig	333..424	CDD:472250	3/10 (30%)
		Ig strand B	353..357	CDD:409353
		Ig strand C	366..370	CDD:409353
		Ig strand E	388..392	CDD:409353
		Ig strand F	402..407	CDD:409353
		Ig strand G	417..420	CDD:409353	0/2 (0%)
		Ig	447..552	CDD:472250	24/126 (19%)
		Ig strand B	450..454	CDD:409353	1/9 (11%)
		Ig strand C	463..467	CDD:409353	1/10 (10%)
		Ig strand E	515..519	CDD:409353	1/3 (33%)
		Ig strand F	532..537	CDD:409353	1/4 (25%)
		Ig strand G	545..548	CDD:409353	0/2 (0%)
		IG_like	568..640	CDD:214653	16/82 (20%)
		Ig strand B	573..577	CDD:409353	0/3 (0%)
		Ig strand C	586..594	CDD:409353	1/7 (14%)
		Ig strand E	619..623	CDD:409353	2/3 (67%)
		Ig strand F	633..638	CDD:409353	1/4 (25%)
		I-set	661..748	CDD:400151	25/125 (20%)
		Ig strand B	679..682	CDD:409353	0/6 (0%)
		Ig strand C	691..695	CDD:409353	1/3 (33%)
		Ig strand E	714..718	CDD:409353	3/12 (25%)
		Ig strand F	728..733	CDD:409353	2/4 (50%)
		Protein Kinases, catalytic domain	819..1157	CDD:473864	88/344 (26%)