Protein Alignment Egfr and Alk

DIOPT Version :10

• Sequence 1: NP_476759.1
• Gene: Egfr / 37455
• FlyBaseID: FBgn0003731
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: NP_652600.1
• Gene: Alk / 53425
• FlyBaseID: FBgn0040505
• Length: 1701
• Species: Drosophila melanogaster
• Alignment Length: 1546
• Identity: 313/1546 - (20%)
• Similarity: 500/1546 - (32%)
• Gaps: 549/1546 - (35%)

  Fly   137 ELTWLPNENLDLSFLDNIREVTGYILISHVDVKKVVFPKLQIIRG-RTLFSLSVEEEKYALFVTY 200
            |.:|:|.|.|.    ||:|:.|           :.|:...::.|. |.:|.:
  Fly   390 ESSWVPAEILG----DNVRQWT-----------RKVYRLGRVSRDFRIVFEV------------- 426

  Fly   201 SKMYTLEIPDLRDVLNGQVGFHNNYNLCHMRTIQWSEIVSNGTDAYYNYDFTAPERECPKCHESC 265
                   :||||....|.|...|      :|.:
  Fly   427 -------VPDLRVGQKGHVALDN------LRMV-------------------------------- 446

  Fly   266 THGCWGEGPKNCQKFSKLTCSPQCAGG--RCYGPKPRECCHL--FCAGGCTGPTQKDCIACKNFF 326
              .|:.||.|          |.:|:..  :|...|...|.||  .|      ...:||...:
  Fly   447 --NCFPEGTK----------SEKCSTSQVKCTSSKVPVCIHLPRIC------DITRDCDEAE--- 490

  Fly   327 DEGVCKEECPPMRKYNPTTYVLETNPEGKYAYGATCVKECPGHLLRDNGACVRSCPQDKMDKGGE 391
            ||   ::.|                  .|..||..|..|......||:|....:..:   ..|..
  Fly   491 DE---QQSC------------------DKIPYGGRCDFEEDWCGWRDSGKTTLTWSR---HTGSS 531

  Fly   392 CVPCNGP--------CPKTCPGVTVL-----HAGNIDSFRNCTV-IDGNIRILDQTFSGFQDVYA 442
            .....||        ......|..:|     |..|  |.:|..: ...|..::.:||:....|:.
  Fly   532 PTHDTGPDGDHTMQHLQNNTSGYYMLVNMNQHMNN--SEKNSIIGFASNAIMVSKTFNPPPSVHG 594

  Fly   443 NYTMGPRYIPLDPERLEVFSTVKEITGYLNIEGTHPQFRNLSYF-----RNLETI-------HGR 495
            |        |..|.|....     :..:::..|.:|...|||..     .|:.|.       .|.
  Fly   595 N--------PDSPYRNSCV-----VRFFIHQFGKNPGSINLSVVEMKEKENITTTLWWSTKNQGS 646

  Fly   496 QLMESMFAALAIVKSSLYSLEMRNLKQISSGSVVIQHN-RDLCYVSNIRWPAIQKEPEQKV---- 555
            ..|.:.:....|........|.|...:|.|...|...: ...|:..||        ||..:
  Fly   647 DWMRAEYVLPNITSKYYLQFEARMGMRIYSDVAVDDFSLSPECFGLNI--------PEDHLGGYN 703

  Fly   556 -W-VNENLRADL---CEKNGTICSDQCNEDGCWGAGTDQCLTCKNFNFNGTCIADCGYISNAYKF 615
             | |.:||::..   .|....:....|:..|..|....||                   ..||:.
  Fly   704 YWDVRQNLKSPTYKDFEYTNYLELTTCDTRGMIGPSQAQC-------------------EAAYRE 749

  Fly   616 DNRTCKICHPECRTCNGAGADHCQECVHVRDGQHCVSECPKNKYNDRGVCRECHAT--CDGCTGP 678
            .|:|                 |....|||.:.|.......|.|     |..|.|.|  ..|.:|.
  Fly   750 QNKT-----------------HVLREVHVVEDQSSYKGMQKWK-----VPHEGHYTIIAKGASGG 792

  Fly   679 KDTIGIGACTTCNLAIINNDATVKRCLLKDDKCPDGYFWEYVHPQEQGSLKPLAGRAVCRKCHPL 743
            ..:.|:|          ::..:|...:|:..|..:.||              |.|:
  Fly   793 LGSGGVG----------SSRGSVAVAILELHKNEELYF--------------LVGQ--------- 824

  Fly   744 CELCTNYGYHEQVCSKCTHYKRREQCETECPADHYTDEEQRECFQCHPEC-------NGCTGPGA 801
                    ..|..|.|.....:    |..|..||..|..|.. |:...:.       ||..|.|.
  Fly   825 --------QGENACIKSMGVLK----EAGCGTDHDLDLAQYS-FRSKQDMVKNIYIENGAGGGGG 876

  Fly   802 ---------------------------------DDCKSCRNFKLFDANETGPYVNSTMFNCTS-- 831
                                             :|.:..:..|...|.|:| .:|....|..:
  Fly   877 GSYVFLLNQAKNEAVPLLVAGGGGGLGIGQYIDEDFQHGQKAKPLQAPESG-QINGEPLNKKTAG 940

  Fly   832 -----------------------------KCPLEM--------RHVNYQYTAIGPYCAA------ 853
                                         .|.:|:        ||....:...|..|..
  Fly   941 PGGGWRAKEDQALSPTYGAALLQGGRGGHSCYVELADNGTSVHRHGQGGFGGGGGGCNTGGGGGG 1005

  Fly   854 --------------------SPPRS----SKITANLD-----VNMIFIITGA------------- 876
                                ||.||    |:|.|...     :.:|..|.|.
  Fly  1006 YAGGDVYLTESNGEGGSSYISPSRSLREISEIHAGASSGPGAIIIIPAIEGCGCDYRCVALDEFR 1070

  Fly   877 ---------------------------------VLVPTICILCVVTYIC-------------RQK 895
                                             .||..:.|...|.:||             |:|
  Fly  1071 SKVRCICPDGWSLKRDNHTACEIREEAGKSSFQYLVSILMISLAVLFICIAALIFMLYNRYQRKK 1135

  Fly   896 QKAKK------ETVKMTMALSGCEDS-----------EPLRPSNIGANLCKLRIVKDAELRKGGV 943
            |..|:      :.:::|...:..:||           :.:...:|..|... ::.:|: |:....
  Fly  1136 QSKKRHKMLVEQDLQLTRLRNNIDDSNLNNFNPNYGCDGILNGHIDVNSLP-QVARDS-LQLVNA 1198

  Fly   944 LGMGAFGRVYKGVW-VPEGENVKIPVAIKELLKSTGAESSEEFLREAYIMASVEHVNLLKLLAVC 1007
            ||.||||.||..:: ..:|:.|::.||:|.|.:....|..|:||:||.|||...|.|::.|:.||
  Fly  1199 LGKGAFGEVYMALYRHRDGDAVEMGVAVKTLREDPKREKEEDFLKEAAIMAKFNHPNMVHLIGVC 1263

  Fly  1008 MSSQ-MMLITQLMPLGCLLDYVRNNRDK------IGSKALLNWSTQIAKGMSYLEEKRLVHRDLA 1065
            ...| ..::.:|:..|.|..::|.||:.      :..|.||..:..:|||..|:|.||.:|||:|
  Fly  1264 FDRQPYYIVLELLAGGDLQKFLRENRNTPERPSLLTMKDLLFCALDVAKGCRYMESKRFIHRDIA 1328

  Fly  1066 ARNVLVQTPS---LVKITDFGLAK-LLSSDSNEYKAAGGK--MPIKWLALECIRNRVFTSKSDVW 1124
            |||.|:.:..   :|||.|||::: :..||   |...|||  :||||:..|...:.:||||:|||
  Fly  1329 ARNCLLSSKGPGRVVKIADFGMSRDIYRSD---YYRKGGKAMLPIKWMPPEAFLDGIFTSKTDVW 1390

  Fly  1125 AFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQ 1189
            :||:.:||:.:.|:.|:.......:.:|:..|.:|..|..|.:.||..:..||:.....||||..
  Fly  1391 SFGILLWEVFSLGRSPYPGQHNTQVMELVVRGGRLGSPTECPVSIYKVMADCWNPTPEDRPTFIT 1455

  Fly  1190 LTTVFAEFARDPGRYLAIPGDKFTRLPAYTSQDEKDLIRKLAPTTDGSEAIAEPDDYLQPKAAPG 1254
            |........:|    .:|.......:...|:.:..|.:  :.|.......:|.| |||.| ..||
  Fly  1456 LLEHLTACTQD----ASIMNAPLPNILGPTASERDDTV--IRPPNGEEFCLAVP-DYLVP-LPPG 1512

  Fly  1255 PSHRTDC---TDEIPKLNRYCKDPSNKNSSTGDDETDSSAREVGVGNLRLDLPVD---------- 1306
            .|:....   :..:|:|.|     ...:|.|....|..:|..        ..||:
  Fly  1513 GSNNPSMASGSGYVPELQR-----QQMSSCTPPAVTSPAAPH--------PRPVENIAPTSGDCW 1564

  Fly  1307 EDDYLMPTCQPGPNNNNNINNPNQNNMAAVGVAAGYMDLIGVPVSVDNPEYLLNAQTLGVGESPI 1371
            |..:::|        |:.:..|...:...|.:|.|....:   :|:|.|:             |.
  Fly  1565 ETSFILP--------NSKVEPPVVGSGHDVPLAGGEEAKL---ISLDTPQ-------------PT 1605

  Fly  1372 PTQTIGIPVM------GV---PGTMEVKVPMPGSEPTSSDHEYYNDTQREL 1413
            || ||..|:.      |:   |..:...:|...::.:.::.:..|:.:.::
  Fly  1606 PT-TIQPPLSFASQLDGITLDPSALTKSLPNGNAKQSYANVQVKNEAEAKV 1655

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Egfr	NP_476759.1	Recep_L_domain	128..239	CDD:460032	21/102 (21%)
		Furin-like	253..401	CDD:395614	28/159 (18%)
		Recep_L_domain	419..547	CDD:460032	27/141 (19%)
		GF_recep_IV	572..684	CDD:464344	22/113 (19%)
		FU	662..716	CDD:214589	11/55 (20%)
		GF_recep_IV	740..>834	CDD:464344	21/164 (13%)
		PTKc_EGFR_like	930..1208	CDD:270648	100/291 (34%)
Alk	NP_652600.1	MAM	288..447	CDD:99706	21/131 (16%)
		MAM	505..689	CDD:99706	37/201 (18%)
		PTKc_ALK_LTK	1186..1462	CDD:270632	99/280 (35%)