DRSC/TRiP Functional Genomics Resources

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Protein Alignment Egfr and NTRK3

DIOPT Version :10

Sequence 1:NP_476759.1 Gene:Egfr / 37455 FlyBaseID:FBgn0003731 Length:1426 Species:Drosophila melanogaster
Sequence 2:XP_016877743.1 Gene:NTRK3 / 4916 HGNCID:8033 Length:850 Species:Homo sapiens


Alignment Length:979 Identity:226/979 - (23%)
Similarity:359/979 - (36%) Gaps:265/979 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   362 CVKECP-------GHLLRDNGACVRSCPQDKMDKGGECVPCNGPCPKTCPGVTVLHAGNIDSFRN 419
            |..:|.       |.:..|....|.:||       ..||     |.||          .|    |
Human     6 CPAKCSFWRIFLLGSVWLDYVGSVLACP-------ANCV-----CSKT----------EI----N 44

  Fly   420 C-TVIDGNI-RILDQTFSGFQDVYANYTMGPRYIPLDPERLEVFSTVKEITGYLNIEGTHPQFRN 482
            | ...|||: .:|:...||..:..|:..:      .|..|              ||...|     
Human    45 CRRPDDGNLFPLLEGQDSGNSNGNASINI------TDISR--------------NITSIH----- 84

  Fly   483 LSYFRNLETIHGRQL-MESMFAALAIVKSSLYSLEMR------NLKQISSGSVVIQHNRDLCYVS 540
            :..:|:|.|::...: :.:....|.|..|.|.|::.|      :|:.|:..|     ||    ::
Human    85 IENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSS-----NR----LT 140

  Fly   541 NIRWPAIQKEPEQKVWVNENLRADLCEKNGTICSDQCNEDGCWGAGTDQCLTCKNFNFNGTCIAD 605
            .:.|...|         ..:||....|:|...||........|....:..|..:|.    .||..
Human   141 TLSWQLFQ---------TLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNL----YCINA 192

  Fly   606 CGYISNAYKFDNRTCKICHPECRTCNGAGADHCQECVHVRDGQHCVSECPKNKYNDRGVCRECHA 670
            .|.....::.:...|.:  ||      ....|..  :.||:|.:.|                  .
Human   193 DGSQLPLFRMNISQCDL--PE------ISVSHVN--LTVREGDNAV------------------I 229

  Fly   671 TCDGCTGP---KDTIGIGACTTCNLAIINNDATVKRCLLKDDKCPDGYFWEYVH----------P 722
            ||:|...|   .|.|..|      |..||...|             ...|..||          .
Human   230 TCNGSGSPLPDVDWIVTG------LQSINTHQT-------------NLNWTNVHAINLTLVNVTS 275

  Fly   723 QEQGSLKPLAGRAVCRKCHPLCELCTNYGYHEQVCSKCTHYKRREQC------ETECPADHYTDE 781
            ::.|.........|....:....| |.| |..:|.|......|.|.|      ....|..|:...
Human   276 EDNGFTLTCIAENVVGMSNASVAL-TVY-YPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHN 338

  Fly   782 EQ--RECFQCHPE-------CNGCTGPGADDCKSCRNFKLFDANETGPYVNSTMFNCTSKCPLEM 837
            .|  ||....|.|       ..||.........:..|:.|...|..|. .|.|:.....|.|...
Human   339 GQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGT-ANQTINGHFLKEPFPE 402

  Fly   838 RHVNY-QYTAIGPYCAASPPRSSKITANLDVNMIFIITGAVLVPTICILCVVTYICRQKQ-KAKK 900
            ...|: .:..:.|    :||.:.......|...:.|..|  |....|:|.||.::...|. :..|
Human   403 STDNFILFDEVSP----TPPITVTHKPEEDTFGVSIAVG--LAAFACVLLVVLFVMINKYGRRSK 461

  Fly   901 ETVKMTMA-LSGCEDS-EPLR--------PSNIGA-------NLCKLRIVKDAELRKGG------ 942
            ..:|..:| :||.||| .||.        ||::.|       .:.::.::::.:..:.|      
Human   462 FGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKP 526

  Fly   943 ----------------VLGMGAFGRVYKGVWVPEGENV-----KIPVAIKELLKSTGAESSEEFL 986
                            .||.||||:|:    :.|..|:     |:.||:|.|...|.| :.::|.
Human   527 DTYVQHIKRRDIVLKRELGEGAFGKVF----LAECYNLSPTKDKMLVAVKALKDPTLA-ARKDFQ 586

  Fly   987 REAYIMASVEHVNLLKLLAVCMSSQ-MMLITQLMPLGCLLDYVRNN---------------RDKI 1035
            |||.::.:::|.:::|...||.... ::::.:.|..|.|..::|.:               :.::
Human   587 REAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGEL 651

  Fly  1036 GSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAK-LLSSD-------- 1091
            |...:|:.::|||.||.||..:..||||||.||.||....||||.|||::: :.|:|        
Human   652 GLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYREGPCQ 716

  Fly  1092 --------------SNEYKAAGG--KMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRP 1140
                          :......||  .:||:|:..|.|..|.||::||||:|||.:||:.|:|::|
Human   717 KGPFSVVWQRQRLAATAASTVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQP 781

  Fly  1141 HENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARDPGRYL 1205
            ...:...::.:.|..|..||:|.:|..::|..:|.||..:...|...|::..:.....:....||
Human   782 WFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYL 846

  Fly  1206 AIPG 1209
            .|.|
Human   847 DILG 850

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EgfrNP_476759.1 Recep_L_domain 128..239 CDD:460032
Furin-like 253..401 CDD:395614 10/45 (22%)
Recep_L_domain 419..547 CDD:460032 29/136 (21%)
GF_recep_IV 572..684 CDD:464344 22/114 (19%)
FU 662..716 CDD:214589 11/56 (20%)
GF_recep_IV 740..>834 CDD:464344 25/108 (23%)
PTKc_EGFR_like 930..1208 CDD:270648 93/345 (27%)
NTRK3XP_016877743.1 LRR_8 103..160 CDD:404697 16/74 (22%)
leucine-rich repeat 105..128 CDD:275378 6/22 (27%)
leucine-rich repeat 129..151 CDD:275378 7/39 (18%)
leucine-rich repeat 152..164 CDD:275378 4/11 (36%)
LRRCT_2 163..208 CDD:465313 8/48 (17%)
ig 214..299 CDD:395002 21/123 (17%)
Ig strand B 227..231 CDD:409568 1/21 (5%)
Ig strand C 240..244 CDD:409568 1/3 (33%)
Ig strand E 266..270 CDD:409568 0/3 (0%)
Ig strand F 281..286 CDD:409568 0/4 (0%)
Ig strand G 294..297 CDD:409568 0/2 (0%)
IgI_TrKABC_d5 304..396 CDD:409360 20/92 (22%)
Ig strand A 305..311 CDD:409360 2/5 (40%)
Ig strand A' 313..316 CDD:409360 0/2 (0%)
Ig strand B 319..327 CDD:409360 1/7 (14%)
Ig strand C 330..337 CDD:409360 2/6 (33%)
Ig strand C' 340..343 CDD:409360 1/2 (50%)
Ig strand D 348..354 CDD:409360 2/5 (40%)
Ig strand E 358..366 CDD:409360 2/7 (29%)
Ig strand F 374..382 CDD:409360 2/7 (29%)
Ig strand G 385..393 CDD:409360 3/8 (38%)
PTKc_TrkC 532..843 CDD:270676 90/315 (29%)
Blue background indicates that the domain is not in the aligned region.

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