DRSC/TRiP Functional Genomics Resources

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Protein Alignment Egfr and drl

DIOPT Version :9

Sequence 1:NP_476759.1 Gene:Egfr / 37455 FlyBaseID:FBgn0003731 Length:1426 Species:Drosophila melanogaster
Sequence 2:NP_001260566.1 Gene:drl / 44355 FlyBaseID:FBgn0015380 Length:645 Species:Drosophila melanogaster


Alignment Length:613 Identity:130/613 - (21%)
Similarity:225/613 - (36%) Gaps:142/613 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   672 CDGCTGPKDTIGIGACTTCNLAIINNDATV---KRCLLKDDKCPDGYFWEYVHPQEQGSLKPLAG 733
            |.|....:.|:.|......:.|..||...:   |:..|::::  |....||    :...|..|  
  Fly   119 CSGTRNAEVTVTINVEVILDRATNNNTNLIFKRKKICLREEQ--DSAHEEY----DDDDLDLL-- 175

  Fly   734 RAVCRKCHPLCELCTNYGYHEQVCSKCTHYKRREQCETECPADHYTDEEQRECFQCHPECNGCTG 798
             ...||.|                ....||..|.. |......|...|:||......|...|.:|
  Fly   176 -QTARKGH----------------GGDIHYVDRND-EHVVANGHQAPEKQRPVVTESPVGRGNSG 222

  Fly   799 PGADDCKSCRNFKLFDANETGPYVNSTMFNCTSKCPLEMRHVNYQYTAIGPYCAASPPRSSKITA 863
            ....|         ||     |.:...:.                           ||.|..:| 
  Fly   223 GSKRD---------FD-----PMLRENLV---------------------------PPASGLVT- 245

  Fly   864 NLDVNMIFIITGAVLVPTICILCVVTYICRQKQK---------------AKKETVKMTM--ALSG 911
                   .|:.|.:.:..:..|.::.|..:...|               .:..|:..|.  ::..
  Fly   246 -------LIVGGILALVLVSTLILIAYCAKGPSKRHPSNGVHLIKTSSFQRLPTISSTAHNSIYV 303

  Fly   912 CED---------SEPLR-----PSNIGANLCKLRIVKDAELRKGGVLGMGAFGRVYKGVWVPEGE 962
            |..         :.|.|     |......|.:|.:.| ..:|...::..|.|||:|:|.:..   
  Fly   304 CPSTITPTYATLTRPFREYEHEPEEFNRRLQELTVQK-CRVRLSCLVQEGNFGRIYRGTYND--- 364

  Fly   963 NVKIPVAIKELLKSTGAESSEE-----FLREAYIMASVEHVNLLKLLAVCMSSQMMLITQLMPLG 1022
                   .:|:|..|.|:.:.:     .|:|:.::....|.|:|.:|.:.:.............|
  Fly   365 -------CQEVLVKTVAQHASQLQVNLLLQESMMLYEASHPNVLSVLGISIEDYATPFVLYAATG 422

  Fly  1023 CLLDYVRNNRDKIGSKALLNWST-----QIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDF 1082
            .:.:.....:|...::::....|     |:|..|.:|....::|:|:||||.::.....||:||.
  Fly   423 SVRNLKSFLQDPSYARSVTTIQTVLMGSQLAMAMEHLHNHGVIHKDIAARNCVIDDQLRVKLTDS 487

  Fly  1083 GLAK-LLSSDSN-----EYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPH 1141
            .|:: |...|.|     ||:      |||||:||.::...:...||||:|||.:||:.|.|:.|:
  Fly   488 ALSRDLFPGDYNSLGDGEYR------PIKWLSLEALQKSHYNEGSDVWSFGVLMWEMCTLGKLPY 546

  Fly  1142 ENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARDPGRYLA 1206
            ..|...::...::.|.:|.||..|..:::..:..||....|.||:|.||....:||.....||: 
  Fly   547 AEIDPYEMEHYLKDGYRLAQPFNCPDELFTIMAYCWASMPAERPSFSQLQICLSEFHTQITRYVX 611

  Fly  1207 IPGDKFTRLPAYTSQDEKDLIRKLAPTT 1234
            ....|..:...|..:..:.:.::...:|
  Fly   612 PAVLKHAKTCKYNKRRRRKIFQQTTSST 639

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EgfrNP_476759.1 Recep_L_domain 419..547 CDD:279382
GF_recep_IV 572..684 CDD:291509 3/11 (27%)
FU 573..>606 CDD:238021
FU 617..659 CDD:214589
FU 662..716 CDD:214589 10/46 (22%)
FU 739..786 CDD:238021 10/46 (22%)
FU 784..834 CDD:214589 8/49 (16%)
PTKc_EGFR_like 930..1208 CDD:270648 79/293 (27%)
STYKc 938..1194 CDD:214568 73/271 (27%)
Recep_L_domain 128..239 CDD:279382
Furin-like 253..401 CDD:279142
FU 255..292 CDD:214589
FU 302..345 CDD:238021
drlNP_001260566.1 WIF 21..157 CDD:128745 8/37 (22%)
PTK_Ryk 336..606 CDD:270639 77/286 (27%)
Pkinase_Tyr 343..599 CDD:285015 73/271 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45455335
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1025
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR24416
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
43.840

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