DRSC/TRiP Functional Genomics Resources

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Protein Alignment Egfr and InR

DIOPT Version :9

Sequence 1:NP_476759.1 Gene:Egfr / 37455 FlyBaseID:FBgn0003731 Length:1426 Species:Drosophila melanogaster
Sequence 2:NP_001138093.1 Gene:InR / 42549 FlyBaseID:FBgn0283499 Length:2144 Species:Drosophila melanogaster


Alignment Length:2033 Identity:413/2033 - (20%)
Similarity:649/2033 - (31%) Gaps:791/2033 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 LLLLLAHCICIWPASAARDRYARQNNRQRHQDIDR--------DRDRDR-FLYRSSSAQNRQRGG 70
            ||||..........|.:...|.:|...|.:|.:.|        ::||.: |.|:.:.:.:   .|
  Fly   210 LLLLQTLAAATTRLSLSPKNYKQQQQLQHNQQLPRATPQQKQQEKDRHKCFHYKHNYSYS---PG 271

  Fly    71 ANFAL------GLGANGVTIPTSLEDKNKNEFVKG--KICI---GTKSR-------------LSV 111
            .:..|      .|....|.:|...:....|:...|  |..:   ||:||             .:|
  Fly   272 ISLLLFILLANTLAIQAVVLPAHQQHLLHNDIADGLDKTALSVSGTQSRWTRSESNPTMRLSQNV 336

  Fly   112 PSNKEHHYRNLRDRYT---NCTYVDGNLELTWLPNEN-LDLSFLDNIREVTGYILISHV----DV 168
            ...|....||:...:.   |||.::|.|.:..:.:.: |:.|| ..:.|||.||:|..|    .:
  Fly   337 KPCKSMDIRNMVSHFNQLENCTVIEGFLLIDLINDASPLNRSF-PKLTEVTDYIIIYRVTGLHSL 400

  Fly   169 KKVVFPKLQIIRGRTLFSLSVEEEKYALFVTYSK--MYTLEIPDLRDVLNGQVGFHNNYNLCHMR 231
            .| :||.|.:|||..||      :.||| |.||.  :..|.:..||.:..|.|....|:.||:.|
  Fly   401 SK-IFPNLSVIRGNKLF------DGYAL-VVYSNFDLMDLGLHKLRSITRGGVRIEKNHKLCYDR 457

  Fly   232 TIQWSEIVSNGTDAYYNYDFTAPEREC--PKC---------HE----------SC-THG----CW 270
            ||.|.||::..............|:||  .||         |:          || .|.    ||
  Fly   458 TIDWLEILAENETQLVVLTENGKEKECRLSKCPGEIRIEEGHDTTAIEGELNASCQLHNNRRLCW 522

  Fly   271 GEGPKNCQKFSKLTCSPQCAGGRCYGPKPRECCHLFCAGGC----TGPTQKDCIACKNFFDEGVC 331
            ..  |.||......|...|.       ....||...|.|||    .|  .:.||:|:|.....:|
  Fly   523 NS--KLCQTKCPEKCRNNCI-------DEHTCCSQDCLGGCVIDKNG--NESCISCRNVSFNNIC 576

  Fly   332 KEECPPMRKYNPTTYVLETNPEGKYAYGATCV--KEC------------PGHLLRDNGACVRSCP 382
            .:.|                |:|.|.:.:.||  .||            .|  :..||.|:..||
  Fly   577 MDSC----------------PKGYYQFDSRCVTANECITLTKFETNSVYSG--IPYNGQCITHCP 623

  Fly   383 --QDKMDKGGECVPC-NGPCPKTCPGVTVLHAGNIDS------FRNCTVIDG------------N 426
              ..|.:....|.|| .|.|.|.|      .:|.|||      |..||:|.|            .
  Fly   624 TGYQKSENKRMCEPCPGGKCDKEC------SSGLIDSLERAREFHGCTIITGTEPLTISIKRESG 682

  Fly   427 IRILDQTFSGFQDVYANYTMGPRYIPLDPERLEVFSTVKEITGYLNIEGTHPQFRNLSYFRNLET 491
            ..::|:...|                        .:.|.:|...|.:..|: ..::|.:|::|..
  Fly   683 AHVMDELKYG------------------------LAAVHKIQSSLMVHLTY-GLKSLKFFQSLTE 722

  Fly   492 IHGRQLMESMFAALAIVKSSLYSLEMRNLKQ---------ISSGSVVIQHNRDLCYVSNIR--WP 545
            |.|...|::       .|.:||.|:.|:|.:         |..|.|....|..|| ||.|.  .|
  Fly   723 ISGDPPMDA-------DKYALYVLDNRDLDELWGPNQTVFIRKGGVFFHFNPKLC-VSTINQLLP 779

  Fly   546 AIQKEPE---------------------------QKVWVNENL-----RADLCE----KNGTIC- 573
            .:..:|:                           |.|..|..:     :.::.|    .|.||. 
  Fly   780 MLASKPKFFEKSDVGADSNGNRGSCGTAVLNVTLQSVGANSAMLNVTTKVEIGEPQKPSNATIVF 844

  Fly   574 --------------------SDQCNEDGC---WGAGTDQC------------------------- 590
                                |.:.::|.|   |...:.:.                         
  Fly   845 KDPRAFIGFVFYHMIDPYGNSTKSSDDPCDDRWKVSSPEKSGVMVLSNLIPYTNYSYYVRTMAIS 909

  Fly   591 --LT-----CKNFNFN-----------GTCIADC------GYISNAY----------KFDNR--- 618
              ||     .|||..|           .|.|:|.      .|:...|          |..||   
  Fly   910 SELTNAESDVKNFRTNPGRPSKVTEVVATAISDSKINVTWSYLDKPYGVLTRYFIKAKLINRPTR 974

  Fly   619 ------------------------TCKICHP---ECRTCNGAGADHCQECVHVRDGQHCVSECPK 656
                                    |.||..|   :|:...|:.....||                
  Fly   975 NNNRDYCTEPLVKAMENDLPATTPTKKISDPLAGDCKCVEGSKKTSSQE---------------- 1023

  Fly   657 NKYNDR-------------------GVCRECHATCDGCTGPKDTIGIGACTTCNLAIINNDAT-- 700
              |:||                   .:.:..:.:.|...|.:     ||....| ||.|..||  
  Fly  1024 --YDDRKVQAGMEFENALQNFIFVPNIRKSKNGSSDKSDGAE-----GAALDSN-AIPNGGATNP 1080

  Fly   701 ---------------VKRCLL-------KDDKCPDGYFW---EYVHPQEQGSLKPLAGRAVCRKC 740
                           |:..:|       .||  .|.:|.   |..:..|:               
  Fly  1081 SRRRRDVALEPELDDVEGSVLLRHVRSITDD--TDAFFEKDDENTYKDEE--------------- 1128

  Fly   741 HPLCELCTNYGYHEQ------------VCSKCTHYKRRE----QCETECPADHYTDEEQRE--C- 786
                :|.:|..::|.            |..|..|:.|..    .|..|.|::...|...::  | 
  Fly  1129 ----DLSSNKQFYEVFAKELPPNQTHFVFEKLRHFTRYAIFVVACREEIPSEKLRDTSFKKSLCS 1189

  Fly   787 -----FQCH----------------PECNGCTGP-------------------------GADDCK 805
                 ||..                ...|....|                         ..|..:
  Fly  1190 DYDTVFQTTKRKKFADIVMDLKVDLEHANNTESPVRVRWTPPVDPNGEIVTYEVAYKLQKPDQVE 1254

  Fly   806 SCRNFKLFDANETGPY---VNSTMFNCTSKCP--------LEMRHVNYQYTAIGPYCAASPPRSS 859
            ..:.....|.|:|..|   :|..:::...:..        .|:.|:..:          .||..:
  Fly  1255 EKKCIPAADFNQTAGYLIKLNEGLYSFRVRANSIAGYGDFTEVEHIKVE----------PPPSYA 1309

  Fly   860 KITANLDVNMIFIITGAVLVPTICILCVVTYIC-RQKQKAKKETVKMTMALSGC--------EDS 915
            |:        .|.:.|..|  ...|:.:..|:| ..|:|.....:.|...::..        :|.
  Fly  1310 KV--------FFWLLGIGL--AFLIVSLFGYVCYLHKRKVPSNDLHMNTEVNPFYASMQYIPDDW 1364

  Fly   916 EPLRPSNIGANLCKLRIVKDAELRKGGVLGMGAFGRVYKGV---WVPEGENVKIPVAIKELLKST 977
            |.||     .|:.:|           ..||.|:||.||:|:   :.|.|  |....|||.:.::.
  Fly  1365 EVLR-----ENIIQL-----------APLGQGSFGMVYEGILKSFPPNG--VDRECAIKTVNENA 1411

  Fly   978 GAESSEEFLREAYIMASVEHVNLLKLLAVCMSSQ-MMLITQLMPLGCLLDYVRNNRDKIGSKALL 1041
            .......||.||.:|...:..::::||.||...| .:::.:||..|.|..|:|.:|.:...:|::
  Fly  1412 TDRERTNFLSEASVMKEFDTYHVVRLLGVCSRGQPALVVMELMKKGDLKSYLRAHRPEERDEAMM 1476

  Fly  1042 NW---------------------STQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLA 1085
            .:                     :.:||.||:||..|:.|||||||||.:|.....|||.|||:.
  Fly  1477 TYLNRIGVTGNVQPPTYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMT 1541

  Fly  1086 KLLSSDSNEYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIP 1150
            :.:.......|...|.:|::|:..|.:|:.|::|.|||::|||.:||:.|...:|::.:..:.:.
  Fly  1542 RDIYETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVL 1606

  Fly  1151 DLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPT----------------FKQLTTVFAE--- 1196
            ..:..|..:|:||.|...::..:..|||..::.||:                ||:::...:|   
  Fly  1607 RYVIDGGVMERPENCPDFLHKLMQRCWHHRSSARPSFLDIIAYLEPQCPNSQFKEVSFYHSEAGL 1671

  Fly  1197 ---------------FARDP--------------------GRY-------------LAIPGDKFT 1213
                           ||..|                    |.|             :|:..|:.:
  Fly  1672 QHREKERKERNQLDAFAAVPLDQDLQDREQQEDATTPLRMGDYQQNSSLDQPPESPIAMVDDQGS 1736

  Fly  1214 RLP--------AYTSQDEKDLIR---KLAPTTDG--SEAIAEPD-DYL-----------QPKAAP 1253
            .||        |.::.|.:.::.   :..|...|  |.....|| |.|           .||.|.
  Fly  1737 HLPFSLPSGFIASSTPDGQTVMATAFQNIPAAQGDISATYVVPDADALDGDRGYEIYDPSPKCAE 1801

  Fly  1254 GPSHRTDCT------DEIPKLNRYCKDPSNKNSSTGDD------------ETDSSAREVGVGNLR 1300
            .|:.|:..|      .|...|.|..:.|:..:||..||            ...||......|...
  Fly  1802 LPTSRSGSTGGGKLSGEQHLLPRKGRQPTIMSSSMPDDVIGGSSLQPSTASAGSSNASSHTGRPS 1866

  Fly  1301 LDLPVDE---------DDYLMPTCQPGPNNNNNINNPN------QNNMAAVGVAAGYMDLI---- 1346
            |...|.:         :.:|....:.|.|.::..|..|      ..|:.:..||.|.:..|    
  Fly  1867 LKKTVADSVRNKANFINRHLFNHKRTGSNASHKSNASNAPSTSSNTNLTSHPVAMGNLGTIESGG 1931

  Fly  1347 ------------------------GVPVSVDNPEYLLNAQTLGVGESPI---------------- 1371
                                    |:.:| |||.|.|..:::...::.|                
  Fly  1932 SGSAGSYTGTPRFYTPSATPGGGSGMAIS-DNPNYRLLDESIASEQATILTTSSPNPNYEMMHPP 1995

  Fly  1372 ----------------PTQTIGIPVMGVPGTMEVKVPMPGSEPTSS------------------D 1402
                            |.|..|:.:...|....::.|:...:..||                  |
  Fly  1996 TSLVSTNPNYMPMNETPVQMAGVTISHNPNYQPMQAPLNARQSQSSSDEDNEQEEDDEDEDDDVD 2060

  Fly  1403 HEYYNDTQRELQPLHRNR 1420
            .|:....:.|..||.|.|
  Fly  2061 DEHVEHIKMERMPLSRPR 2078

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EgfrNP_476759.1 Recep_L_domain 419..547 CDD:279382 32/150 (21%)
GF_recep_IV 572..684 CDD:291509 32/243 (13%)
FU 573..>606 CDD:238021 12/99 (12%)
FU 617..659 CDD:214589 10/71 (14%)
FU 662..716 CDD:214589 16/96 (17%)
FU 739..786 CDD:238021 11/64 (17%)
FU 784..834 CDD:214589 11/101 (11%)
PTKc_EGFR_like 930..1208 CDD:270648 93/369 (25%)
STYKc 938..1194 CDD:214568 85/296 (29%)
Recep_L_domain 128..239 CDD:279382 43/117 (37%)
Furin-like 253..401 CDD:279142 48/194 (25%)
FU 255..292 CDD:214589 16/62 (26%)
FU 302..345 CDD:238021 13/46 (28%)
InRNP_001138093.1 Recep_L_domain 356..465 CDD:279382 43/117 (37%)
Furin-like 512..645 CDD:279142 41/161 (25%)
FU 545..592 CDD:238021 16/64 (25%)
Recep_L_domain 663..781 CDD:279382 32/150 (21%)
FN3 1224..1302 CDD:238020 8/77 (10%)
PTKc_InsR_like 1364..1652 CDD:173625 88/305 (29%)
Pkinase_Tyr 1371..1650 CDD:285015 84/291 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45455329
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR24416
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
32.940

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