DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Egfr and htl

DIOPT Version :9

Sequence 1:NP_476759.1 Gene:Egfr / 37455 FlyBaseID:FBgn0003731 Length:1426 Species:Drosophila melanogaster
Sequence 2:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster


Alignment Length:786 Identity:181/786 - (23%)
Similarity:296/786 - (37%) Gaps:249/786 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   518 RNLKQIS------SGSVVIQHNRDLCYV-----SNIRWPAIQKEPEQKVWVNENLRADLCEKNGT 571
            ||.|::|      |||::..:    |:.     .||.|                      .:|||
  Fly   104 RNPKKMSFLQTRPSGSLLTLN----CHALGNPEPNITW----------------------YRNGT 142

  Fly   572 ICSDQCNEDGCWGAGTDQ----CLTCKNFNFNGTCIADCGYISNAYKFDNRTCKICHPECRTCNG 632
            :       |...|.|:.:    .||.::.     ...|||         |.|||:       ||.
  Fly   143 V-------DWTRGYGSLKRNRWTLTMEDL-----VPGDCG---------NYTCKV-------CNS 179

  Fly   633 AGADHCQECVHVRDGQHCVSECPKNKYNDRGVCRECHATCDGCTGPKDTIGIGACTTCNLAIINN 697
            .|      |:. .|.|..||:    :.|.:.:.         .|||           .||.::.|
  Fly   180 LG------CIR-HDTQVIVSD----RVNHKPIL---------MTGP-----------LNLTLVVN 213

  Fly   698 DATVKRCLLKDDKCPDGYFWEYVHPQEQGSLKPLAGRAVCRKCHPLCELCTNYGYHEQVCSKCTH 762
            ......|....| ......|.:|                  .||.:    ||...:..:.::   
  Fly   214 STGSMHCKYLSD-LTSKKAWIFV------------------PCHGM----TNCSNNRSIIAE--- 252

  Fly   763 YKRREQCETECPADHYTDEEQRECFQCHPECNGCTGPGADDCKSCRNFKLFDANETGPYVNSTMF 827
                             |::|.:......|..|.             :...::|..| ..|||.:
  Fly   253 -----------------DKDQLDFVNVRMEQEGW-------------YTCVESNSLG-QSNSTAY 286

  Fly   828 NCTSKCPLEMRHVNYQYTAIGPYCAASPPRSSKITANLDVNMIFIITGAVLV--PTICILCVVTY 890
                     :|.|...:.......:.|...:|.:       .||:..|.:.:  .|:.:...:..
  Fly   287 ---------LRVVRSLHVLEAGVASGSLHSTSFV-------YIFVFGGLIFIFMTTLFVFYAIRK 335

  Fly   891 ICRQK-QKAKKETV----------------------------------KMTMALSGCEDSEPLR- 919
            :..:| .|.:.|||                                  :.|..|....:..|.. 
  Fly   336 MKHEKVLKQRIETVHQWTKKVIIFKPEGGGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFNE 400

  Fly   920 ---PSNIGANLCKLRIVKDAELRKGGVLGMGAFGRVYKGVWVPEGENVKIPVAIKELLKSTGAES 981
               |.:....|.:..:|      .|..||.||||||.    :.|..|.  .||:|.:.:....:.
  Fly   401 YEFPLDSNWELPRSHLV------LGATLGEGAFGRVV----MAEVNNA--IVAVKMVKEGHTDDD 453

  Fly   982 SEEFLREAYIMASV-EHVNLLKLLAVC-MSSQMMLITQLMPLGCLLDYVRNNR------DK---- 1034
            ....:||..:|..: .|:|::.||..| .:..:.:|.:..|.|.|.|::..||      |:    
  Fly   454 IASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQ 518

  Fly  1035 ---------IGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSS 1090
                     |..|.|:.::.|||:||.||..:|.:|||||||||||....::||.|||||:.:.|
  Fly   519 PPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQS 583

  Fly  1091 DSNEYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENI-PAKDIPDLIE 1154
            .....|...|::||||:|.|.::.:.:.||||||::|:.:||::|:||:|:..| .|:::...:.
  Fly   584 TDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLM 648

  Fly  1155 VGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARDPGRYLAIPGDKFTRLPAYT 1219
            .|.::|:|..||::||..:..|||.:|..||.|.::.....:..:....||.:........|: |
  Fly   649 SGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQTKEDYLDVDIANLDTPPS-T 712

  Fly  1220 SQDEKD 1225
            |.:|:|
  Fly   713 SDEEED 718

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EgfrNP_476759.1 Recep_L_domain 419..547 CDD:279382 11/39 (28%)
GF_recep_IV 572..684 CDD:291509 24/115 (21%)
FU 573..>606 CDD:238021 5/36 (14%)
FU 617..659 CDD:214589 12/41 (29%)
FU 662..716 CDD:214589 8/53 (15%)
FU 739..786 CDD:238021 6/46 (13%)
FU 784..834 CDD:214589 7/49 (14%)
PTKc_EGFR_like 930..1208 CDD:270648 100/299 (33%)
STYKc 938..1194 CDD:214568 97/277 (35%)
Recep_L_domain 128..239 CDD:279382
Furin-like 253..401 CDD:279142
FU 255..292 CDD:214589
FU 302..345 CDD:238021
htlNP_524394.2 Ig 112..191 CDD:299845 28/139 (20%)
IG_like 113..191 CDD:214653 28/138 (20%)
IG_like 205..289 CDD:214653 21/160 (13%)
PKc_like 404..692 CDD:304357 100/299 (33%)
STYKc 416..688 CDD:214568 98/283 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45455233
Domainoid 1 1.000 165 1.000 Domainoid score I1208
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR24416
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
43.940

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