DRSC/TRiP Functional Genomics Resources

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Protein Alignment Egfr and LTK

DIOPT Version :10

Sequence 1:NP_476759.1 Gene:Egfr / 37455 FlyBaseID:FBgn0003731 Length:1426 Species:Drosophila melanogaster
Sequence 2:NP_002335.2 Gene:LTK / 4058 HGNCID:6721 Length:864 Species:Homo sapiens


Alignment Length:582 Identity:143/582 - (24%)
Similarity:240/582 - (41%) Gaps:142/582 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   665 CRECHATCDGCTGPKDTIGIGACTT--CNLAIINNDATVKRCLLKDDKCPDGYFWEYVHPQEQGS 727
            |.|..||...........|.||||.  ........||:....|..|.:  ||.  .::||..:..
Human   300 CSEAWATLGWAAAGGFGGGGGACTAGGGGGGYRGGDASETDNLWADGE--DGV--SFIHPSSELF 360

  Fly   728 LKPLAGRAVCRKCHPLCELCTNYGYHEQVCSKCTHYKRREQCETECPADHYTDEEQREC-FQCHP 791
            |:|||             :..|:|..|        .:|...| :.||.        |:| :|...
Human   361 LQPLA-------------VTENHGEVE--------IRRHLNC-SHCPL--------RDCQWQAEL 395

  Fly   792 ECNGCTGPG----ADDCKSCRNFKLFDANETGPYVNSTMFNCTSKCPLEMRHVNYQYTAIGPYCA 852
            :...|..|.    |.|..:|.:.                    .|.|             ||.  
Human   396 QLAECLCPEGMELAVDNVTCMDL--------------------HKPP-------------GPL-- 425

  Fly   853 ASPPRSSKITANLDVNMIFIITGAVLVPTICILCVVTYICRQKQKAKKETVKM-----------T 906
                          |.|:.::..:.|  ::.::|.|..:.:||:....:.:::           |
Human   426 --------------VLMVAVVATSTL--SLLMVCGVLILVKQKKWQGLQEMRLPSPELELSKLRT 474

  Fly   907 MALS------------GCEDSEPLRP--SNIG-ANLCKLRIVKDAELRKGGVLGMGAFGRVYKG- 955
            .|:.            |...|.||.|  :.:. ||:..||           .||.||||.||:| 
Human   475 SAIRTAPNPYYCQVGLGPAQSWPLPPGVTEVSPANVTLLR-----------ALGHGAFGEVYEGL 528

  Fly   956 -VWVPEGENVKIPVAIKELLKSTGAESSEEFLREAYIMASVEHVNLLKLLAVCM-SSQMMLITQL 1018
             :.:| |::..:.||||.|.:....:...:||.||.|::...|.|:::.:.:.: ::..:::.:|
Human   529 VIGLP-GDSSPLQVAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLEL 592

  Fly  1019 MPLGCLLDYVRNNRDKIGS------KALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQT--PS 1075
            |..|.:..::|::|..:|.      :.||..:..||:|..||||...:|||:||||.|:..  ||
Human   593 MSGGDMKSFLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPS 657

  Fly  1076 LV-KITDFGLAKLLSSDSNEYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQR 1139
            .| ||.|||:|:.:...|...:.....:|:||:..|.....:||||:|.|:|||.:||:.:.|..
Human   658 RVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYM 722

  Fly  1140 PHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARDP 1201
            |:.....:::.|.:..|.:::.|..|...:|..:..||..:..:||:|..:........:||
Human   723 PYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYCTQDP 784

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EgfrNP_476759.1 Recep_L_domain 128..239 CDD:460032
Furin-like 253..401 CDD:395614
Recep_L_domain 419..547 CDD:460032
GF_recep_IV 572..684 CDD:464344 4/18 (22%)
FU 662..716 CDD:214589 15/52 (29%)
GF_recep_IV 740..>834 CDD:464344 16/98 (16%)
PTKc_EGFR_like 930..1208 CDD:270648 87/284 (31%)
LTKNP_002335.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 30..64
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 239..297
PTKc_ALK_LTK 503..779 CDD:270632 87/287 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 790..830
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 842..864
Blue background indicates that the domain is not in the aligned region.

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