DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Egfr and btl

DIOPT Version :9

Sequence 1:NP_476759.1 Gene:Egfr / 37455 FlyBaseID:FBgn0003731 Length:1426 Species:Drosophila melanogaster
Sequence 2:NP_001014583.1 Gene:btl / 39564 FlyBaseID:FBgn0285896 Length:1052 Species:Drosophila melanogaster


Alignment Length:1272 Identity:265/1272 - (20%)
Similarity:426/1272 - (33%) Gaps:475/1272 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   162 LISHVDVKKVVFPKLQIIRGRTLFSLSVEEEKYALFVTYSKMYTLEIPDLRDVLNGQVGFHNNYN 226
            |:|.:|:      .||.:|....:   ..|:|:.|..|   :..||        ..|.|...||.
  Fly    45 LLSDMDI------TLQCVRPMAKW---FYEDKFQLRAT---LLRLE--------RAQSGNSGNYG 89

  Fly   227 LCHMRTIQW---------SEIVSNGTDAYYNYDF--TAPEREC--PKCHESCTHGCWGEGPKNCQ 278
             |.....:|         .|.|.|...::...:.  ..||.:.  ...:||.:.......||..|
  Fly    90 -CLDSQNRWYNISLVVGHKEPVGNDIASFVKLEDAPALPESDLFFQPLNESRSLKLLQPLPKTVQ 153

  Fly   279 KFS----KLTCSP-----------------QCAGGR----------CYGP-KPREC----CHLFC 307
            :.:    :|.|||                 |..|||          ..|. :|.:.    |.|..
  Fly   154 RTAGGLFQLNCSPMDPDAKGVNISWLHNDTQILGGRGRIKLKRWSLTVGQLQPEDAGSYHCELCV 218

  Fly   308 AGGC--TGPTQKDCIACKNFFDEGVCKEECPPMRK--YNPTTYVLETNPEGKYAYGATCVKECPG 368
            ...|  :.|||.:.|:          ::...||.|  |...|.:         |.|.....||  
  Fly   219 EQDCQRSNPTQLEVIS----------RKHTVPMLKPGYPRNTSI---------ALGDNVSIEC-- 262

  Fly   369 HLLRDNGACVRSCPQDKMDKGGECVPCNGPCPKTCPGVTVLHAGNIDSFRNCTVIDGNI-RILDQ 432
             ||.|:.                          ..|.:|.||.||.|:      ||..: |:.:|
  Fly   263 -LLEDSA--------------------------LEPKITWLHKGNADN------IDDLLQRLREQ 294

  Fly   433 TFSGFQDVYANYTMGPRYIPLDPERLEVFSTVKEITGYLNIEGTHPQFRNLSYFRNLETIHGRQL 497
            :                .:|:|..||        ||     ....||...|          |..|
  Fly   295 S----------------QLPVDVTRL--------IT-----RMDEPQVLRL----------GNVL 320

  Fly   498 MESMFAALAIVKSSLYSLEMRNLKQISSGSVVIQHNRDLCYVSNIRWPAIQKEPEQKVWVNENLR 562
            ||.....:.|.::.:             |..|.....||            ..|.....|.....
  Fly   321 MEDGGWYICIAENQV-------------GRTVAASYVDL------------YSPSDTTTVRTTTT 360

  Fly   563 ADLCEKNGTICSDQCNEDGCWGAGTDQCLTCKNFNFNGTCIADCGYISNAYKFDNRTCKICHPEC 627
            ..:.....|..:.:.|:|                                        .:.:|..
  Fly   361 TTVASPIPTASTGEDNDD----------------------------------------DVENPAA 385

  Fly   628 RTCNGAGADHCQECVHVRDGQHCVS------ECP----------KNK---YNDRGVCRECHATCD 673
            ....|.|....::  .::..||.:|      .||          |:|   ..:.||..:.:.|..
  Fly   386 EASGGVGPPVFRK--ELKRLQHSLSGNTVNLACPVYGKANITWTKDKKPLNRELGVYVQKNWTLR 448

  Fly   674 GCTGPKDTIGIGACTTCN--------LAIINNDATVKRCLLKDDKCPDGYFWEYVHPQEQ----- 725
            ......:..|:..|..||        .::..||.|....::             |.||.|     
  Fly   449 FVEATSEDSGLYNCKVCNAWGCIQFDFSVQINDRTRSAPII-------------VVPQNQTVKVN 500

  Fly   726 GSLKPLAGRAVCRKCHPLCELCTNYGYHEQVCSKCTHYKRREQCETECPADHYTDEEQRECFQCH 790
            |||                            ..|||.|.                       ..|
  Fly   501 GSL----------------------------VMKCTVYS-----------------------DLH 514

  Fly   791 PECNGCTGPGADDCKSCRNFKLFDANETG------PYVNSTMFNCTSKCPLEMRHVNYQ----YT 845
            |..            |.:...|.:|:..|      ..:|.|:.|  ....|.:|:|.:.    ||
  Fly   515 PTV------------SWKRVVLKNASLDGLKSVEIQNLNFTVTN--DSVVLTLRNVTFDQEGWYT 565

  Fly   846 AIGPYCAAS------------------PPRSSKITANLDVNMIFIITGAVLVPTICIL--CVVTY 890
                 |.||                  ||  .:|.|.|..:.:.....|:.:..:.:|  ..:|:
  Fly   566 -----CLASSGLGRSNSSVYLRVVSPLPP--LEIYALLHAHPLGFTLAAITIVALFLLGSAFITF 623

  Fly   891 ICRQKQKAKK-----ETV-----------------------------------KMTMALSGCEDS 915
            :.|:.::.|.     |||                                   :.|::.:|...:
  Fly   624 MLRRLRREKLLKLRIETVHQWTKKVIIYRPGGEEGSGCSSGDLQMPVIRIEKQRTTVSTTGTGGT 688

  Fly   916 EPLRPSNIGANLCKLRI-----VKDAELRKGGVLGMGAFGRVYKGVWVPEGENV-KIP------V 968
            :|.:    |.|..:..:     :...:|..|.:||.||||||.    :.|.|.: :.|      |
  Fly   689 DPAQ----GFNEYEFPLDSNWEIPRQQLSLGSILGEGAFGRVV----MAEAEGLPRSPQLAETIV 745

  Fly   969 AIKELLKSTGAESSEEFLREAYIMASV-EHVNLLKLLAVC-MSSQMMLITQLMPLGCLLDYVRNN 1031
            |:|.:.:..........:||..:|..: :|:|::.||..| ....:.:|.:..|.|.|.|:::.|
  Fly   746 AVKMVKEEHTDTDMASLVREMEVMKMIGKHINIINLLGCCSQGGPLWVIVEYAPHGNLKDFLKQN 810

  Fly  1032 R---------------DK-------IGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTP 1074
            |               ||       :|.|.|..::.|||:||.||..:|.:|||||||||||...
  Fly   811 RPGAPQRRSDSDGYLDDKPLISTQHLGEKELTKFAFQIARGMEYLASRRCIHRDLAARNVLVSDG 875

  Fly  1075 SLVKITDFGLAKLLSSDSNEYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQR 1139
            .::||.|||||:.:.......|...|::||||:|.|.::.:.:.|:||||::||.:||::|:|.:
  Fly   876 YVMKIADFGLARDIQDTEYYRKNTNGRLPIKWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQ 940

  Fly  1140 PHENI-PAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVF----AEFAR 1199
            |:.:| .|:::...:..|.::|:|..|||:||..:..|||.::..||||.:|...|    .:.:.
  Fly   941 PYPHILSAEELYSYLITGQRMEKPAKCSLNIYVVMRQCWHFESCARPTFAELVESFDGILQQASS 1005

  Fly  1200 DPG-RYLAIPGDKFTRLPAYTSQD---EKDLIRKLAP 1232
            :|. .||.:........|:...:|   :.:..|:.:|
  Fly  1006 NPNDAYLDLSMPMLETPPSSGDEDDGSDTETFRETSP 1042

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EgfrNP_476759.1 Recep_L_domain 419..547 CDD:279382 22/128 (17%)
GF_recep_IV 572..684 CDD:291509 15/130 (12%)
FU 573..>606 CDD:238021 2/32 (6%)
FU 617..659 CDD:214589 10/60 (17%)
FU 662..716 CDD:214589 10/61 (16%)
FU 739..786 CDD:238021 4/46 (9%)
FU 784..834 CDD:214589 9/55 (16%)
PTKc_EGFR_like 930..1208 CDD:270648 104/319 (33%)
STYKc 938..1194 CDD:214568 100/287 (35%)
Recep_L_domain 128..239 CDD:279382 19/85 (22%)
Furin-like 253..401 CDD:279142 36/189 (19%)
FU 255..292 CDD:214589 11/59 (19%)
FU 302..345 CDD:238021 11/50 (22%)
btlNP_001014583.1 IG_like 149..232 CDD:214653 19/82 (23%)
IGc2 157..215 CDD:197706 10/57 (18%)
IG 247..336 CDD:214652 33/184 (18%)
Ig 258..340 CDD:143165 31/168 (18%)
I-set 394..479 CDD:254352 14/86 (16%)
IGc2 408..469 CDD:197706 12/60 (20%)
IG_like 492..583 CDD:214653 27/160 (17%)
Ig 507..583 CDD:299845 20/117 (17%)
PKc_like 700..1000 CDD:304357 101/303 (33%)
TyrKc 712..996 CDD:197581 100/287 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45455234
Domainoid 1 1.000 165 1.000 Domainoid score I1208
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR24416
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
43.940

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