DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Egfr and btl

DIOPT Version :10

Sequence 1:NP_476759.1 Gene:Egfr / 37455 FlyBaseID:FBgn0003731 Length:1426 Species:Drosophila melanogaster
Sequence 2:NP_729956.1 Gene:btl / 39564 FlyBaseID:FBgn0285896 Length:1052 Species:Drosophila melanogaster


Alignment Length:1272 Identity:265/1272 - (20%)
Similarity:426/1272 - (33%) Gaps:475/1272 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   162 LISHVDVKKVVFPKLQIIRGRTLFSLSVEEEKYALFVTYSKMYTLEIPDLRDVLNGQVGFHNNYN 226
            |:|.:|:      .||.:|....:   ..|:|:.|..|   :..||        ..|.|...||.
  Fly    45 LLSDMDI------TLQCVRPMAKW---FYEDKFQLRAT---LLRLE--------RAQSGNSGNYG 89

  Fly   227 LCHMRTIQW---------SEIVSNGTDAYYNYDF--TAPEREC--PKCHESCTHGCWGEGPKNCQ 278
             |.....:|         .|.|.|...::...:.  ..||.:.  ...:||.:.......||..|
  Fly    90 -CLDSQNRWYNISLVVGHKEPVGNDIASFVKLEDAPALPESDLFFQPLNESRSLKLLQPLPKTVQ 153

  Fly   279 KFS----KLTCSP-----------------QCAGGR----------CYGP-KPREC----CHLFC 307
            :.:    :|.|||                 |..|||          ..|. :|.:.    |.|..
  Fly   154 RTAGGLFQLNCSPMDPDAKGVNISWLHNDTQILGGRGRIKLKRWSLTVGQLQPEDAGSYHCELCV 218

  Fly   308 AGGC--TGPTQKDCIACKNFFDEGVCKEECPPMRK--YNPTTYVLETNPEGKYAYGATCVKECPG 368
            ...|  :.|||.:.|:          ::...||.|  |...|.:         |.|.....||  
  Fly   219 EQDCQRSNPTQLEVIS----------RKHTVPMLKPGYPRNTSI---------ALGDNVSIEC-- 262

  Fly   369 HLLRDNGACVRSCPQDKMDKGGECVPCNGPCPKTCPGVTVLHAGNIDSFRNCTVIDGNI-RILDQ 432
             ||.|:.                          ..|.:|.||.||.|:      ||..: |:.:|
  Fly   263 -LLEDSA--------------------------LEPKITWLHKGNADN------IDDLLQRLREQ 294

  Fly   433 TFSGFQDVYANYTMGPRYIPLDPERLEVFSTVKEITGYLNIEGTHPQFRNLSYFRNLETIHGRQL 497
            :                .:|:|..||        ||     ....||...|          |..|
  Fly   295 S----------------QLPVDVTRL--------IT-----RMDEPQVLRL----------GNVL 320

  Fly   498 MESMFAALAIVKSSLYSLEMRNLKQISSGSVVIQHNRDLCYVSNIRWPAIQKEPEQKVWVNENLR 562
            ||.....:.|.::.:             |..|.....||            ..|.....|.....
  Fly   321 MEDGGWYICIAENQV-------------GRTVAASYVDL------------YSPSDTTTVRTTTT 360

  Fly   563 ADLCEKNGTICSDQCNEDGCWGAGTDQCLTCKNFNFNGTCIADCGYISNAYKFDNRTCKICHPEC 627
            ..:.....|..:.:.|:|                                        .:.:|..
  Fly   361 TTVASPIPTASTGEDNDD----------------------------------------DVENPAA 385

  Fly   628 RTCNGAGADHCQECVHVRDGQHCVS------ECP----------KNK---YNDRGVCRECHATCD 673
            ....|.|....::  .::..||.:|      .||          |:|   ..:.||..:.:.|..
  Fly   386 EASGGVGPPVFRK--ELKRLQHSLSGNTVNLACPVYGKANITWTKDKKPLNRELGVYVQKNWTLR 448

  Fly   674 GCTGPKDTIGIGACTTCN--------LAIINNDATVKRCLLKDDKCPDGYFWEYVHPQEQ----- 725
            ......:..|:..|..||        .::..||.|....::             |.||.|     
  Fly   449 FVEATSEDSGLYNCKVCNAWGCIQFDFSVQINDRTRSAPII-------------VVPQNQTVKVN 500

  Fly   726 GSLKPLAGRAVCRKCHPLCELCTNYGYHEQVCSKCTHYKRREQCETECPADHYTDEEQRECFQCH 790
            |||                            ..|||.|.                       ..|
  Fly   501 GSL----------------------------VMKCTVYS-----------------------DLH 514

  Fly   791 PECNGCTGPGADDCKSCRNFKLFDANETG------PYVNSTMFNCTSKCPLEMRHVNYQ----YT 845
            |..            |.:...|.:|:..|      ..:|.|:.|  ....|.:|:|.:.    ||
  Fly   515 PTV------------SWKRVVLKNASLDGLKSVEIQNLNFTVTN--DSVVLTLRNVTFDQEGWYT 565

  Fly   846 AIGPYCAAS------------------PPRSSKITANLDVNMIFIITGAVLVPTICIL--CVVTY 890
                 |.||                  ||  .:|.|.|..:.:.....|:.:..:.:|  ..:|:
  Fly   566 -----CLASSGLGRSNSSVYLRVVSPLPP--LEIYALLHAHPLGFTLAAITIVALFLLGSAFITF 623

  Fly   891 ICRQKQKAKK-----ETV-----------------------------------KMTMALSGCEDS 915
            :.|:.::.|.     |||                                   :.|::.:|...:
  Fly   624 MLRRLRREKLLKLRIETVHQWTKKVIIYRPGGEEGSGCSSGDLQMPVIRIEKQRTTVSTTGTGGT 688

  Fly   916 EPLRPSNIGANLCKLRI-----VKDAELRKGGVLGMGAFGRVYKGVWVPEGENV-KIP------V 968
            :|.:    |.|..:..:     :...:|..|.:||.||||||.    :.|.|.: :.|      |
  Fly   689 DPAQ----GFNEYEFPLDSNWEIPRQQLSLGSILGEGAFGRVV----MAEAEGLPRSPQLAETIV 745

  Fly   969 AIKELLKSTGAESSEEFLREAYIMASV-EHVNLLKLLAVC-MSSQMMLITQLMPLGCLLDYVRNN 1031
            |:|.:.:..........:||..:|..: :|:|::.||..| ....:.:|.:..|.|.|.|:::.|
  Fly   746 AVKMVKEEHTDTDMASLVREMEVMKMIGKHINIINLLGCCSQGGPLWVIVEYAPHGNLKDFLKQN 810

  Fly  1032 R---------------DK-------IGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTP 1074
            |               ||       :|.|.|..::.|||:||.||..:|.:|||||||||||...
  Fly   811 RPGAPQRRSDSDGYLDDKPLISTQHLGEKELTKFAFQIARGMEYLASRRCIHRDLAARNVLVSDG 875

  Fly  1075 SLVKITDFGLAKLLSSDSNEYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQR 1139
            .::||.|||||:.:.......|...|::||||:|.|.::.:.:.|:||||::||.:||::|:|.:
  Fly   876 YVMKIADFGLARDIQDTEYYRKNTNGRLPIKWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQ 940

  Fly  1140 PHENI-PAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVF----AEFAR 1199
            |:.:| .|:::...:..|.::|:|..|||:||..:..|||.::..||||.:|...|    .:.:.
  Fly   941 PYPHILSAEELYSYLITGQRMEKPAKCSLNIYVVMRQCWHFESCARPTFAELVESFDGILQQASS 1005

  Fly  1200 DPG-RYLAIPGDKFTRLPAYTSQD---EKDLIRKLAP 1232
            :|. .||.:........|:...:|   :.:..|:.:|
  Fly  1006 NPNDAYLDLSMPMLETPPSSGDEDDGSDTETFRETSP 1042

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EgfrNP_476759.1 Recep_L_domain 128..239 CDD:460032 19/85 (22%)
Furin-like 253..401 CDD:395614 36/189 (19%)
Recep_L_domain 419..547 CDD:460032 22/128 (17%)
GF_recep_IV 572..684 CDD:464344 15/130 (12%)
FU 662..716 CDD:214589 10/61 (16%)
GF_recep_IV 740..>834 CDD:464344 13/99 (13%)
PTKc_EGFR_like 930..1208 CDD:270648 104/319 (33%)
btlNP_729956.1 Ig 143..215 CDD:472250 13/71 (18%)
Ig strand B 160..164 CDD:409570 1/3 (33%)
Ig strand C 175..179 CDD:409570 0/3 (0%)
Ig strand E 197..201 CDD:409570 0/3 (0%)
Ig strand F 211..215 CDD:409570 0/3 (0%)
Ig_3 247..333 CDD:464046 33/168 (20%)
Ig 398..479 CDD:472250 14/82 (17%)
Ig strand B 412..416 CDD:409393 0/3 (0%)
Ig strand C 423..427 CDD:409393 0/3 (0%)
Ig strand E 445..449 CDD:409393 1/3 (33%)
Ig strand F 459..464 CDD:409393 1/4 (25%)
Ig strand G 472..475 CDD:409393 0/2 (0%)
IG_like 492..583 CDD:214653 27/160 (17%)
Ig strand B 503..507 CDD:409444 1/31 (3%)
Ig strand C 516..520 CDD:409444 1/15 (7%)
Ig strand E 549..553 CDD:409444 1/3 (33%)
Ig strand F 563..568 CDD:409444 3/9 (33%)
Ig strand G 576..579 CDD:409444 0/2 (0%)
Protein Kinases, catalytic domain 700..1000 CDD:473864 101/303 (33%)

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