DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Egfr and erbb2

DIOPT Version :9

Sequence 1:	NP_476759.1	Gene:	Egfr / 37455	FlyBaseID:	FBgn0003731	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_956413.2	Gene:	erbb2 / 386966	ZFINID:	ZDB-GENE-031118-121	Length:	1275	Species:	Danio rerio

Alignment Length:	1490	Identity:	489/1490 - (32%)
Similarity:	675/1490 - (45%)	Gaps:	406/1490 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 GVTIPTSLEDKNKNEFVKGKICIGTKSRLSVPSNKEHHYRNLRDRYTNCTYVDGNLELTWLPNEN 145
            |:|..|..|           :|:||..:|::||:.|:||..||..||.|..|.||||:|.|.. |
Zfish    18 GITAATGRE-----------VCLGTDMKLALPSSLENHYEMLRLLYTGCQVVHGNLEITHLQG-N 70

  Fly   146 LDLSFLDNIREVTGYILISHVDVKKVVFPKLQIIRGRTLFSLSVEEEKYALFVTYSK-------- 202
            .|||||..|.||.||:||:||.|:.:....|:||||..|:     :..|||.|..:.
Zfish    71 PDLSFLQEIVEVQGYVLIAHVSVRSLPLDNLRIIRGSQLY-----KSNYALAVHNNSNSSQAGLG 130

  Fly   203 MYTLEIPDLRDVLNGQVGFHNNYNLCHMRTIQWSEIVSN-GTDAYYNYDFTAPERECPKCHESC- 265
            :..|.:..|.::|.|.|....|..||..|.|.|.:.||. .....:..|.   .:.||:|..:|
Zfish   131 LRELRLRSLTEILLGGVYIWGNPQLCFPRNINWEDTVSKVQNKPLHLQDI---PKNCPRCSSACK 192

  Fly   266 THGCWGEGPKNCQKFSKLTCSPQCAGGRCYGPKPRECCHLFCAGGCTGPTQKDCIACKNFFDEGV 330
            :.|||||..::||..:.:.||..|:  ||.||||.:|||:.||.|||||...||:||::|.|.|.
Zfish   193 SGGCWGEKDQDCQTLTSVNCSSGCS--RCKGPKPSDCCHVQCAAGCTGPKDSDCLACRHFNDSGT 255

  Fly   331 CKEECPPMRKYNPTTYVLETNPEGKYAYGATCVKECPGHLLRDNGACVRSCPQDKMD------KG 389
            ||:.|||...|:|.|:..:.|.:.|:::||||||:||.:.|....||...||:...:      .|
Zfish   256 CKDSCPPPTIYDPITFQSKPNKDKKFSFGATCVKQCPHNYLAMEVACTMVCPKANKEVISVEPDG 320

  Fly   390 GE---CVPCNGPCPKTC--------PGVTVLHAGNIDSFRNCTVIDGNIRILDQTFSGFQDVYAN 443
            .|   |..|.|.|||.|        .||:|:::.||..|..|..|.|::..|..:|.|..|..::
Zfish   321 QETQKCEKCEGECPKVCYGLGMGNLQGVSVVNSTNIGMFTGCEKIYGSLAFLSDSFKGNADTNSS 385

  Fly   444 YTMGPRYIPLDPERLEVFSTVKEITGYLNIEGTHPQFRNLSYFRNLETIHGRQLMESMFAALAIV 508
                    .|.|..||...|::||||||.|:.......:||.|.||:.|.|:.|.:.:| :|.:.
Zfish   386 --------GLQPSDLEKLKTIEEITGYLYIDAWSENLLDLSVFENLKVIRGQMLYKGVF-SLGVQ 441

  Fly   509 KSSLYSLEMRNLKQISSGSVVIQHNRDLCYVSNIRWPAIQKEPEQ--KVWVNENLRADLCEKNGT 571
            ...:.||.:|:|:.:|.|.|:|.:|..|||.|::.|.:: ..|.|  .:..|.|.....|...|.
Zfish   442 SLQIESLGLRSLRSVSGGLVLIHNNSRLCYTSSLPWTSL-LHPTQGPNLISNNNKDQQTCVSEGK 505

  Fly   572 ICSDQCNEDGCWGAGTDQCLTCKNFNFNGTCIADCGYISNAYK--FDNRTCKICHPECR------ 628
            ||...|.:.||||.|..||::|.|:.....|:..|..:..:.:  .|...|..||||||
Zfish   506 ICDPLCGDSGCWGPGPSQCVSCLNYKRGTECVELCNVLHGSVREFEDGFNCVPCHPECRPINGTA 570

  Fly   629 TCNGAGADHCQECVHVRDGQHCVSECPKNKYNDRGVCRECHATCDGCTGPKDTIGIGACTTCNLA 693
            :|.|.|.|.|.:|:|.:||..||..||.      ||..|.|..
Zfish   571 SCTGPGPDQCTDCMHFQDGDVCVERCPS------GVKEEQHTV---------------------- 607

  Fly   694 IINNDATVKRCLLKDDKCPDGYFWEYVHPQEQGSLKPLAGRAVCRKCHPLCELCTNYGYHEQVCS 758
                                   |:|.:              ....|.|
Zfish   608 -----------------------WKYSN--------------ATGHCLP---------------- 619

  Fly   759 KCTHYKRREQCETECPADHYTDEEQRECFQCHPECNGCTGPGADDCKSCRNFKLFDANETGPYVN 823
                      |||
Zfish   620 ----------CET---------------------------------------------------- 622

  Fly   824 STMFNCTSKCPLEMRHVNYQYTAIGPYCAASPPRSSKITANLDVNMIFIITGAVLVPTICILCVV 888
                |||..|||:.|....|... ||                 ...:.|..|.||:..|.:..:|
Zfish   623 ----NCTVSCPLDDRGCPIQQKT-GP-----------------GTTVAITVGGVLLFIILLALLV 665

  Fly   889 TYICRQKQKAKKETVKMTMALSGCEDSEPLRPSNIGANLCKLRIVKDAELRKGGVLGMGAFGRVY 953
            .|:.|||.:.||||::  ..|...|..|||.||....|..::||:|:.||:|..|||.||||.|:
Zfish   666 FYLRRQKHQKKKETIR--RRLQEHELVEPLTPSGAMPNQAQMRILKETELKKLRVLGSGAFGTVF 728

  Fly   954 KGVWVPEGENVKIPVAIKELLKSTGAESSEEFLREAYIMASVEHVNLLKLLAVCMSSQMMLITQL 1018
            ||:|.|:||||:||||||.|.::|..::::|.|.|||:||.|....:.:||.:|::|.:.|:|||
Zfish   729 KGIWAPDGENVRIPVAIKVLRENTSPKANKEILDEAYVMAGVASPYVCRLLGICLTSTVQLVTQL 793

  Fly  1019 MPLGCLLDYVRNNRDKIGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFG 1083
            ||.||||||||.|:|:|||:.||:|..|||||||||||.||||||||||||||:.|:.|||||||
Zfish   794 MPYGCLLDYVRENKDRIGSQYLLSWCVQIAKGMSYLEEVRLVHRDLAARNVLVKNPNHVKITDFG 858

  Fly  1084 LAKLLSSDSNEYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKD 1148
            ||:||..|..||.|.|||:||||:|||.|.:|.||.:||||::|||:|||:|||.:|:|:..|:|
Zfish   859 LARLLDIDEKEYHADGGKVPIKWMALESILHRKFTHQSDVWSYGVTVWELMTFGMKPYESFQARD 923

  Fly  1149 IPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARDPGRYLAIPGDKFT 1213
            ||:|:|.|.:|.||..|:.::|..::.||.:|...||.||.|...|...||||.||:.|..:...
Zfish   924 IPELLEAGERLSQPCNCTKEVYMIMVKCWQIDPDNRPRFKDLVDEFTTMARDPSRYVVIQNEDQM 988

  Fly  1214 RLPAYTSQDEKDLIRKLAPTTDGS-EAIAEPDDYLQPK-----------AAPGP----SHRTDCT 1262
            .|   :|..:.:..|.|.....|: :...:.::||.|:           .|.||    |||:  |
Zfish   989 SL---SSPVDSEFFRILMAEEGGNVKEFLDAEEYLVPQPGSIFNTHGEMRANGPSRHHSHRS--T 1048

  Fly  1263 DEIPKLN---------------------------------------------------------- 1269
            |::.:::
Zfish  1049 DQMVEVDGLPNGRELYSSVSMIEQSQYPTLPVGATANGMWPGTQYPPLARSISHRSAGGQSDSVF 1113

  Fly  1270 ---------------RYCKDPSNKNSSTGDDETDSSAREVGVGN---LRLDLP---------VDE 1307
                           ||.|||:..|...||.|||        ||   |...||         |::
Zfish  1114 LDGYVEDSCPPSSPCRYSKDPTMPNGIDGDLETD--------GNMVFLSHTLPRGTHTQPEYVNQ 1170

  Fly  1308 DDYLMPTCQPG--PNNNNNINNPNQNNMAAVGVAAGYMDLIGVPVSVDNPEYLLNAQTLGVGESP 1370
            |   |.:.:|.  |      ...::......|::.|.        ||:|||||
Zfish  1171 D---MASERPSTLP------RKASERRFILNGLSTGN--------SVENPEYL------------ 1206

  Fly  1371 IPTQTIGIPVMGVPGTMEVKVPMPGSEPTSS--DHEYYNDTQRELQPLHR---NRNTETR 1425
                                ||:....|||.  |:.||:|...:.|.:.|   |..|..|
Zfish  1207 --------------------VPIGSITPTSPAFDNPYYHDIAAKAQAVARVAINGGTNHR 1246

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Egfr	NP_476759.1	Recep_L_domain	419..547	CDD:279382	43/127 (34%)
		GF_recep_IV	572..684	CDD:291509	39/119 (33%)
		FU	573..>606	CDD:238021	12/32 (38%)
		FU	617..659	CDD:214589	20/47 (43%)
		FU	662..716	CDD:214589	4/53 (8%)
		FU	739..786	CDD:238021	5/46 (11%)
		FU	784..834	CDD:214589	3/49 (6%)
		PTKc_EGFR_like	930..1208	CDD:270648	161/277 (58%)
		STYKc	938..1194	CDD:214568	150/255 (59%)
		Recep_L_domain	128..239	CDD:279382	45/118 (38%)
		Furin-like	253..401	CDD:279142	66/157 (42%)
		FU	255..292	CDD:214589	14/37 (38%)
		FU	302..345	CDD:238021	24/42 (57%)
erbb2	NP_956413.2	Recep_L_domain	54..167	CDD:279382	45/118 (38%)
		Furin-like	181..335	CDD:279142	66/155 (43%)
		FU	227..267	CDD:238021	22/39 (56%)
		Recep_L_domain	361..481	CDD:279382	43/129 (33%)
		GF_recep_IV	506..636	CDD:291509	53/276 (19%)
		FU	507..557	CDD:238021	14/49 (29%)
		FU	556..599	CDD:214589	20/48 (42%)
		PTKc_HER2	705..983	CDD:270684	161/277 (58%)
		Pkinase_Tyr	713..969	CDD:285015	150/255 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	342	1.000	Domainoid score	I1044
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45861
OrthoDB	1	1.010	-	-		D51516at33208
OrthoFinder	1	1.000	-	-		FOG0000755
OrthoInspector	1	1.000	-	-		otm25049
orthoMCL	1	0.900	-	-		OOG6_101159
Panther	1	1.100	-	-	LDO	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X448
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.930