DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Egfr and Tie

DIOPT Version :9

Sequence 1:NP_476759.1 Gene:Egfr / 37455 FlyBaseID:FBgn0003731 Length:1426 Species:Drosophila melanogaster
Sequence 2:NP_523928.1 Gene:Tie / 38559 FlyBaseID:FBgn0014073 Length:1233 Species:Drosophila melanogaster


Alignment Length:527 Identity:113/527 - (21%)
Similarity:201/527 - (38%) Gaps:174/527 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   823 NSTMFNCTSKCPLEMRHVNYQYTAIGPYCAASPPR--SSKITAN-LDVNM----------IFIIT 874
            ::|....|:..|......|..|..|....:::.|.  ||.:.|| .|:||          :.:..
  Fly   671 STTTSTTTTAPPAVTAPSNEVYIGIVESSSSASPADISSTVIANERDLNMEMRRMNLVTLVLVAV 735

  Fly   875 GAVLVPTICILCVVTYICRQKQKAKKETVKMTMALSGCEDSEPLRP------------------- 920
            |.:.:..|.:..|..::.|::.| :.|...:.:.     |.:|:.|                   
  Fly   736 GVIPLAAIILYLVRNFVIRRRAK-QSEVFDVCIT-----DQQPISPVKKVDSKYQVDDDEDEVDH 794

  Fly   921 ------------------------------------SNIGANLCKLRIVKD------AELRKGGV 943
                                                :..|.|..|..:..:      :.:|...:
  Fly   795 QHHQHMQHHQNHQNHQNHQHHQAMPMSQASQRDANHNRYGNNDDKTSLASEFHDFERSNIRLKSL 859

  Fly   944 LGMGAFGRVYKGVWVPEGENV-------KIPVAIKELLKSTGAESSEEFLREAYIMASV-EHVNL 1000
            ||.|.||:    ||..|.:::       :| ||:|.:...:...|.::   ||.||..: .|.|:
  Fly   860 LGEGNFGQ----VWKAEADDLSGHFGATRI-VAVKTIRACSAQVSLKD---EANIMRKLGSHQNV 916

  Fly  1001 LKLLAVCMSSQ-MMLITQLMPLGCLLDYVRNNRD----------------KIGSKALLNWSTQIA 1048
            :.||..|:.|: .|||.:....|.||..:|..|.                .:..:.|..::..||
  Fly   917 VTLLGACVESEPHMLIMEYAMRGRLLSLLRAARSATNILPASVPGGRSLAPLSPRTLAGFALDIA 981

  Fly  1049 KGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLA------------------KLLSSDSNEY 1095
            .||.|:..:|:|||||||||||:....:.||.|||::                  .|:..:::::
  Fly   982 CGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEKNAANDLMRHNAHKF 1046

  Fly  1096 KAAGGK-------------------------------------------MPIKWLALECIRNRVF 1117
            |...|.                                           :||:|:|.|.::..:|
  Fly  1047 KFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWMAPESLQYHMF 1111

  Fly  1118 TSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAA 1182
            |:::|:||||:.:||:.|.|..|:..:..:::...:..||:.:.|:....:.|..:..|||.:..
  Fly  1112 TTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLPKESRHEFYNLMSRCWHKEPH 1176

  Fly  1183 MRPTFKQ 1189
            |||:|.|
  Fly  1177 MRPSFAQ 1183

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EgfrNP_476759.1 Recep_L_domain 419..547 CDD:279382
GF_recep_IV 572..684 CDD:291509
FU 573..>606 CDD:238021
FU 617..659 CDD:214589
FU 662..716 CDD:214589
FU 739..786 CDD:238021
FU 784..834 CDD:214589 2/10 (20%)
PTKc_EGFR_like 930..1208 CDD:270648 87/352 (25%)
STYKc 938..1194 CDD:214568 87/338 (26%)
Recep_L_domain 128..239 CDD:279382
Furin-like 253..401 CDD:279142
FU 255..292 CDD:214589
FU 302..345 CDD:238021
TieNP_523928.1 TyrKc 854..1183 CDD:197581 86/336 (26%)
PTKc 860..1187 CDD:270623 86/332 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45455318
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR24416
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
22.030

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