DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Egfr and KDR

DIOPT Version :10

Sequence 1:NP_476759.1 Gene:Egfr / 37455 FlyBaseID:FBgn0003731 Length:1426 Species:Drosophila melanogaster
Sequence 2:NP_002244.1 Gene:KDR / 3791 HGNCID:6307 Length:1356 Species:Homo sapiens


Alignment Length:1508 Identity:314/1508 - (20%)
Similarity:500/1508 - (33%) Gaps:482/1508 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    80 NGVTIPTSLEDKNKNEFVKGKICIGTKSRLSVPSNKEHHYRNLRDRYTNCTYV-DGNLELTWLPN 143
            :||...|  |:|||...:.   |:|:.|.|:|         :|..||....:| ||| .::|   
Human   133 HGVVYIT--ENKNKTVVIP---CLGSISNLNV---------SLCARYPEKRFVPDGN-RISW--- 179

  Fly   144 ENLDLSFLDNIREVTGYILISHVDVKK-VVFPKLQI-IRGRTLFSLSVEEEKYALFVTYSKMYTL 206
                                   |.|| ...|...| ..|.......:.:|.|     .|.||.:
Human   180 -----------------------DSKKGFTIPSYMISYAGMVFCEAKINDESY-----QSIMYIV 216

  Fly   207 EIPDLR--DVL----NG---QVGFHNNYNLCHMRTIQWSEIVSNGTDAYYNYDFTAPERECPKCH 262
            .:...|  ||:    :|   .||.....| |..||     .::.|.|  :|:::.:.:.:..|. 
Human   217 VVVGYRIYDVVLSPSHGIELSVGEKLVLN-CTART-----ELNVGID--FNWEYPSSKHQHKKL- 272

  Fly   263 ESCTHGCWGEGPKNCQKF-SKLTCSPQCAGGRCYGPKPRECCHLFCAGGCTGPTQKDCIACKNFF 326
              .......:.....:|| |.||..                          |.|:.         
Human   273 --VNRDLKTQSGSEMKKFLSTLTID--------------------------GVTRS--------- 300

  Fly   327 DEGV--CKEECPPMRKYNPTTYVLETNPEGKYAYGATCVKECPGHLLRDNGACVR--------SC 381
            |:|:  |......|.|.|.|...:...|...:..|...:.|.      ..|..||        ..
Human   301 DQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEA------TVGERVRIPAKYLGYPP 359

  Fly   382 PQDKMDKGGECVPCNGPCPKTCPGVTVLHAGNIDSFRNCTVIDGNIRILDQTFSGFQDVYANYTM 446
            |:.|..|.|..:..|... |....:|::.....|:.....::...|....|:......||....:
Human   360 PEIKWYKNGIPLESNHTI-KAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQI 423

  Fly   447 GPRYI--PLDPERLEVFSTVKEITGYLNIEGTHPQFRNLSYFRNLETIHGRQLMESMFAALAIVK 509
            |.:.:  |:|..:   :.|.:.:|  ..:....|. .::.::..||.....:      .:.|:..
Human   424 GEKSLISPVDSYQ---YGTTQTLT--CTVYAIPPP-HHIHWYWQLEEECANE------PSQAVSV 476

  Fly   510 SSLYSL-EMRNLKQISSGSVVIQHNRDLCYVSNIRWPAIQKEPEQKVWVNENLRADLCEKNGTIC 573
            ::.|.. |.|:::....|:                          |:.||:|..|.:..||.|: 
Human   477 TNPYPCEEWRSVEDFQGGN--------------------------KIEVNKNQFALIEGKNKTV- 514

  Fly   574 SDQCNEDGCWGAGTDQCLTCKNFNFNGTCIADCGYISNAYKFDNRTCKICHPECRTCNGAGADHC 638
                                      .|.:.....:|..||            |...|..|....
Human   515 --------------------------STLVIQAANVSALYK------------CEAVNKVGRGER 541

  Fly   639 QECVHVRDGQHCVSECPKNKYNDRGV---CRECHATCDGCT----GPKD-TIGIGACTT--C-NL 692
            ....||..|.....:..........|   |....:|.:..|    ||:. .|.:|...|  | ||
Human   542 VISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNL 606

  Fly   693 AII-----------NNDATVKRCLLKDDKCPDGYFWEYVHPQEQGSLKPLAGRAVCRKCHPLCEL 746
            ..:           .||..:..  ||:...           |:||....||.....:|.|.:...
Human   607 DTLWKLNATMFSNSTNDILIME--LKNASL-----------QDQGDYVCLAQDRKTKKRHCVVRQ 658

  Fly   747 CTNYGYHEQVCSKCTHYKRR------EQCETECPADHYTDEEQRECFQCHPECNGCTGPGADDCK 805
            .|   ..|:|....|.....      |..|..|.|                  :|...|      
Human   659 LT---VLERVAPTITGNLENQTTSIGESIEVSCTA------------------SGNPPP------ 696

  Fly   806 SCRNFKLFDANET-----GPYVNSTMFNCTSKCPLEMRHVNYQYTAIGPYCAASPPRSSKITANL 865
               ....|..|||     |..:.....|.|      :|.|..:...:....|.|....:|:.|  
Human   697 ---QIMWFKDNETLVEDSGIVLKDGNRNLT------IRRVRKEDEGLYTCQACSVLGCAKVEA-- 750

  Fly   866 DVNMIFIITGA---------VLVPTICIL----CVVTYICRQKQKAKKETVKMTMALSGCEDSEP 917
                .|||.||         :||.|..|.    .::..|.|..::|....:| |..||...|.:.
Human   751 ----FFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELK-TGYLSIVMDPDE 810

  Fly   918 L----RPSNIGANLCKLRIVKDAELRKGGVLGMGAFGRVYKGVWVPEGENVKI-------PVAIK 971
            |    ....:..:..|....:| .|:.|..||.||||:|.      |.:...|       .||:|
Human   811 LPLDEHCERLPYDASKWEFPRD-RLKLGKPLGRGAFGQVI------EADAFGIDKTATCRTVAVK 868

  Fly   972 ELLKSTGAESSEE--FLREAYIMASV-EHVNLLKLLAVCM--SSQMMLITQLMPLGCLLDYVRNN 1031
             :||. ||..||.  .:.|..|:..: .|:|::.||..|.  ...:|:|.:....|.|..|:|:.
Human   869 -MLKE-GATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSK 931

  Fly  1032 R-----------------DKIGS------------------------------------------ 1037
            |                 |.:|:                                          
Human   932 RNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLY 996

  Fly  1038 ------KALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYK 1096
                  :.|:.:|.|:||||.:|..::.:||||||||:|:...::|||.|||||:.:..|.:..:
Human   997 KDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVR 1061

  Fly  1097 AAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPA-KDIPDLIEVGLKLE 1160
            ....::|:||:|.|.|.:||:|.:||||:|||.:||:.:.|..|:..:.. ::....::.|.::.
Human  1062 KGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMR 1126

  Fly  1161 QPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARDPGRYLAIPGDKFTRLPAYTSQDEKD 1225
            .|:..:.::|.|:|.|||.:.:.||||.:|.......                 |.|...||.||
Human  1127 APDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNL-----------------LQANAQQDGKD 1174

  Fly  1226 LIRKLAPTTDGSEAIA-EPDDYLQPKAAPGPSHRTDCTDEIPKLNRYCKDPSNKNSSTGDDE--- 1286
            .|  :.|.   ||.:: |.|..|....:|     ..|.:|    ...|....:.:::.|..:   
Human  1175 YI--VLPI---SETLSMEEDSGLSLPTSP-----VSCMEE----EEVCDPKFHYDNTAGISQYLQ 1225

  Fly  1287 -TDSSAREVGVGNLRLDLPVDEDDYLMPTCQPGPNNNNNINNPNQNNMAAVGVAAGYMDLIGVPV 1350
             :...:|.|.|.... |:|::|.:..:            |.:.||.:...|              
Human  1226 NSKRKSRPVSVKTFE-DIPLEEPEVKV------------IPDDNQTDSGMV-------------- 1263

  Fly  1351 SVDNPEYLLNAQTLGVGESPIPTQTIGIPVMG--VPGTMEVKVPMPGSEPTS----------SDH 1403
                    |.::.|    ..:..:|...|..|  ||......|...||..||          :|.
Human  1264 --------LASEEL----KTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDT 1316

  Fly  1404 EYYNDTQRELQPL 1416
            ..|:..:.||..|
Human  1317 TVYSSEEAELLKL 1329

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EgfrNP_476759.1 Recep_L_domain 128..239 CDD:460032 26/122 (21%)
Furin-like 253..401 CDD:395614 26/158 (16%)
Recep_L_domain 419..547 CDD:460032 17/130 (13%)
GF_recep_IV 572..684 CDD:464344 17/119 (14%)
FU 662..716 CDD:214589 16/75 (21%)
GF_recep_IV 740..>834 CDD:464344 18/104 (17%)
PTKc_EGFR_like 930..1208 CDD:270648 96/355 (27%)
KDRNP_002244.1 IgI_VEGFR 224..326 CDD:409448 27/147 (18%)
Ig strand A 224..228 CDD:409448 2/3 (67%)
Ig strand A' 234..238 CDD:409448 0/3 (0%)
Ig strand B 240..249 CDD:409448 2/9 (22%)
Ig strand C 256..261 CDD:409448 2/6 (33%)
Ig strand C' 264..266 CDD:409448 0/1 (0%)
Ig strand D 270..278 CDD:409448 1/10 (10%)
Ig strand E 286..294 CDD:409448 4/7 (57%)
Ig strand F 304..310 CDD:409448 1/5 (20%)
Ig strand G 315..321 CDD:409448 2/5 (40%)
IgI_VEGFR-2 329..417 CDD:409450 15/94 (16%)
Ig strand A 329..332 CDD:409450 0/2 (0%)
Ig strand A' 339..343 CDD:409450 1/9 (11%)
Ig strand B 345..356 CDD:409450 3/10 (30%)
Ig strand C 360..366 CDD:409450 2/5 (40%)
Ig strand C' 368..371 CDD:409450 1/2 (50%)
Ig strand D 376..379 CDD:409450 0/3 (0%)
Ig strand E 381..386 CDD:409450 1/4 (25%)
Ig strand F 394..402 CDD:409450 0/7 (0%)
Ig strand G 408..417 CDD:409450 1/8 (13%)
IG_like 565..661 CDD:214653 24/111 (22%)
I-set 667..754 CDD:400151 21/125 (17%)
Ig strand B 684..688 CDD:409353 1/3 (33%)
Ig strand C 697..701 CDD:409353 0/3 (0%)
Ig strand E 720..724 CDD:409353 2/9 (22%)
Ig strand F 734..739 CDD:409353 0/4 (0%)
VEGFR-2_TMD 759..793 CDD:375470 6/33 (18%)
PTKc_VEGFR2 826..1167 CDD:270681 98/366 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1274..1318 11/43 (26%)

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