DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Egfr and egfra

DIOPT Version :9

Sequence 1:	NP_476759.1	Gene:	Egfr / 37455	FlyBaseID:	FBgn0003731	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_919405.1	Gene:	egfra / 378478	ZFINID:	ZDB-GENE-030918-1	Length:	1191	Species:	Danio rerio

Alignment Length:	1381	Identity:	509/1381 - (36%)
Similarity:	707/1381 - (51%)	Gaps:	296/1381 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 KICIGTKSRLSVPSNKEHHYRNLRDRYTNCTYVDGNLELTWLPNENLDLSFLDNIREVTGYILIS 164
            |:|.|..::|::....|.||:.|...|.|||.|..|||:|.: .|..|||||.:|:||.||:||:
Zfish    26 KVCQGANNKLTLLGTVEDHYQVLLRMYRNCTVVLENLEITHI-TEKYDLSFLKSIQEVGGYVLIA 89

  Fly   165 HVDVKKVVFPKLQIIRGRTLFSLSVEEEKYALFVTYSKMYTLE-------IPDLRDVLNGQVGFH 222
            ...|.|:....|:||||.:|:     |:|:||.|..:...::|       :..|.::|.|.|.|.
Zfish    90 VNTVSKIPLENLRIIRGHSLY-----EDKFALAVLVNFNNSIEQGVKELPLTSLTEILKGGVKFC 149

  Fly   223 NNYNLCHMRTIQWSEIV---SNGTDAYYNYDFTAPERECPKCHESCTHG-CWGEGPKNCQKFSKL 283
            .|..||::.||:|::|:   |..|...:|..:   .:.|.||..||.:| |||.||..||:.:|:
Zfish   150 RNDYLCNVGTIEWADILNMKSLPTIVSHNISY---GKNCGKCDPSCFNGSCWGTGPDKCQRMTKV 211

  Fly   284 TCSPQCAGGRCYGPKPRECCHLFCAGGCTGPTQKDCIACKNFFDEGVCKEECPPMRKYNPTTYVL 348
            .|:.||: |||.||:|.:||:..||.|||||...||:|||:|.|||.||:.||.:..|:|.|:.|
Zfish   212 ICAEQCS-GRCKGPRPIDCCNEHCAAGCTGPRPTDCLACKDFQDEGTCKDACPRLMLYDPNTHQL 275

  Fly   349 ETNPEGKYAYGATCVKECP-GHLLRDNGACVRSCPQD--KMDKGG--ECVPCNGPCPKTCPG--- 405
            ..||.|||::||||:|.|| .:::.|:|||||:|...  ::|:||  :|..|.|.|||.|.|
Zfish   276 APNPYGKYSFGATCIKTCPHNYVVTDHGACVRTCSPGTYEVDEGGVRKCKRCEGLCPKVCNGLGM 340

  Fly   406 -----VTVLHAGNIDSFRNCTVIDGNIRILDQTFSGFQDVYANYTMGPRYIPLDPERLEVFSTVK 465
                 |..::|.|||||.|||.|.||:.||..||.|  |.:.| |.|     |||.:|.|.||||
Zfish   341 GPLANVLSINATNIDSFENCTKISGNVAILSTTFRG--DPHTN-TSG-----LDPAKLSVLSTVK 397

  Fly   466 EITGYLNIEGTHPQFRNLSYFRNLETIHGRQLMESMFAALAIVKSSLYSLEMRNLKQISSGSVVI 530
            ||||||.|:......::||.|.|||.|.||...:..: :.|:.|:::..|.||:|::||.|.|.|
Zfish   398 EITGYLMIQLWPESMQSLSAFENLEVIRGRTKTQGTY-SFAVTKTAITHLGMRSLREISDGDVSI 461

  Fly   531 QHNRDLCYVSNIRWPAIQKEPEQKVWVNENLRADLCEKNGTICSDQCNEDGCWGAGTDQCLTCKN 595
            ..|::|||.|...|..:.|..:|.|.:.||:.|..|....:.|::.|..|||||.|...|..|::
Zfish   462 VKNKNLCYSSPEHWKRLFKSKQQSVKMIENMDAATCANQNSTCNEMCTADGCWGPGPTMCFGCEH 526

  Fly   596 FNFNGTCIADCGYIS---NAYKFDNRTCKICHPEC------RTCNGAGADHCQECVHVRDGQHCV 651
            ::....|:|.|..::   ..|:. |:||..|.|||      :||||.|.|.|..|.:.:||.|||
Zfish   527 YSRGKHCVASCNLLNGEPREYEV-NKTCMECDPECLLMNETQTCNGPGPDKCTVCANYKDGPHCV 590

  Fly   652 SECPKNKYNDRGVCRECHATCDGCTGPKDTIGIGACTTCNLAIINNDATVKRCLLKDDKCPDGYF 716
            ..||:                 |..|.|||:                                 .
Zfish   591 HRCPQ-----------------GVPGEKDTL---------------------------------I 605

  Fly   717 WEYVHPQEQGSLKPLAGRAVCRKCHPLCELCTNYGYHEQVCSKCTHYKRREQCETECPADHYTDE 781
            |:|.....           ||:.||   |.||
Zfish   606 WKYADVTH-----------VCQPCH---ENCT--------------------------------- 623

  Fly   782 EQRECFQCHPECNGCTGPGADDCKSCRNFKLFDANETGPYVNSTMFNCTSKCPLEMRHVNYQYTA 846
                        .|||||   |.|.|::||                  :|..|:
Zfish   624 ------------QGCTGP---DLKDCKDFK------------------SSGLPM----------- 644

  Fly   847 IGPYCAASPPRSSKITANLDVNMIFIITGAVLVPTICILCVVTYICRQKQKAKKETVKMTMALSG 911
                          |.|.        :.|.:|...|..|.|.. :.|::...:|.|::  ..|..
Zfish   645 --------------IAAG--------VVGGLLAFVILALGVAV-LLRRRHIRRKRTLR--RLLQE 684

  Fly   912 CEDSEPLRPSNIGANLCKLRIVKDAELRKGGVLGMGAFGRVYKGVWVPEGENVKIPVAIKELLKS 976
            .|..|||.||....|...|||:|:.|.:|..|||.||||.|:||:|||||||||||||||.|.::
Zfish   685 RELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVHKGLWVPEGENVKIPVAIKVLREA 749

  Fly   977 TGAESSEEFLREAYIMASVEHVNLLKLLAVCMSSQMMLITQLMPLGCLLDYVRNNRDKIGSKALL 1041
            |..::::|.:.|||:||||||.::.:||.:|::|.:.|||||||.||||||||.|:|:|||:.||
Zfish   750 TSPKANKEIMDEAYVMASVEHPHVCRLLGICLTSTVQLITQLMPYGCLLDYVRENKDRIGSQHLL 814

  Fly  1042 NWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAGGKMPIKW 1106
            ||..||||||:||||:.|||||||||||||:||..||||||||||||::|..||.|.|||:||||
Zfish   815 NWCVQIAKGMNYLEERHLVHRDLAARNVLVKTPQHVKITDFGLAKLLNADEKEYHADGGKVPIKW 879

  Fly  1107 LALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYC 1171
            :|||.|::|.:|.:||||::|||:|||:|||.:|::.|||.:|..::|.|.:|.||.||::|:|.
Zfish   880 MALESIQHRTYTHQSDVWSYGVTVWELMTFGTKPYDGIPASEIAGVLEKGERLPQPPICTIDVYM 944

  Fly  1172 TLLSCWHLDAAMRPTFKQLTTVFAEFARDPGRYLAIPGDKFTRLPAYTSQDEKDLIRKLAPTTDG 1236
            .::.||.:||..||.|::|...|.:.||||.|||.|.||....||   |..:....|.|. :.:.
Zfish   945 IMVKCWMIDAESRPRFRELIAEFTKMARDPSRYLVIQGDDRMHLP---SPSDSKFYRSLM-SGEL 1005

  Fly  1237 SEAIAEPDDYLQPK----AAPGPSHRTDCTDEIPKLNRYCKDPSNKNSSTGDDETDSSAREVGVG 1297
            .||: :.|:||.|.    ::|..| ||.....:           :.|||.|:..:.:       |
Zfish  1006 DEAV-DADEYLVPNHSFFSSPSTS-RTQLLHSV-----------SLNSSFGNCNSRN-------G 1050

  Fly  1298 NLRLDLPVDEDDYLM-----PT-------CQPGPNNNNNINNPNQNNM----------------- 1333
            |   ..||.|:..::     ||       .||.|..|..:|. |:::|
Zfish  1051 N---GYPVRENSMVLRYIPDPTERFQEGDFQPAPGYNEYMNQ-NESSMINPVYQQPHGPPRTLLH 1111

  Fly  1334 ---AAVGVAAGYMDLIGVPVSVDNPEYLLNAQTLGVGESPIPTQTIGIPVMGVPG------TMEV 1389
               |.......|::....|......|||..:.|..:...|..:       |..|.      .:|:
Zfish  1112 SSPALDETEEEYLNCFKSPAPASVVEYLNTSHTQLLSTKPFFS-------MDNPDYQQDFCPLEL 1169

  Fly  1390 KVPMPGSEPTSSDHEY 1405
            |....|..|.:.:.||
Zfish  1170 KTHTNGHLPAAQNQEY 1185

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Egfr	NP_476759.1	Recep_L_domain	419..547	CDD:279382	57/127 (45%)
		GF_recep_IV	572..684	CDD:291509	41/120 (34%)
		FU	573..>606	CDD:238021	12/32 (38%)
		FU	617..659	CDD:214589	22/47 (47%)
		FU	662..716	CDD:214589	5/53 (9%)
		FU	739..786	CDD:238021	5/46 (11%)
		FU	784..834	CDD:214589	11/49 (22%)
		PTKc_EGFR_like	930..1208	CDD:270648	168/277 (61%)
		STYKc	938..1194	CDD:214568	155/255 (61%)
		Recep_L_domain	128..239	CDD:279382	46/117 (39%)
		Furin-like	253..401	CDD:279142	75/153 (49%)
		FU	255..292	CDD:214589	17/37 (46%)
		FU	302..345	CDD:238021	24/42 (57%)
egfra	NP_919405.1	Recep_L_domain	54..166	CDD:279382	46/117 (39%)
		Furin-like	184..333	CDD:279142	75/149 (50%)
		FU	229..274	CDD:238021	25/44 (57%)
		Recep_L_domain	359..479	CDD:279382	57/128 (45%)
		GF_recep_IV	503..634	CDD:291509	57/243 (23%)
		FU	550..596	CDD:214589	22/62 (35%)
		PTKc_EGFR	703..1014	CDD:270683	179/315 (57%)
		Pkinase_Tyr	711..967	CDD:285015	155/255 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	342	1.000	Domainoid score	I1044
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45861
OrthoDB	1	1.010	-	-		D51516at33208
OrthoFinder	1	1.000	-	-		FOG0000755
OrthoInspector	1	1.000	-	-		otm25049
orthoMCL	1	0.900	-	-		OOG6_101159
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X448
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.930