DRSC/TRiP Functional Genomics Resources

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Protein Alignment Egfr and Nrk

DIOPT Version :10

Sequence 1:NP_476759.1 Gene:Egfr / 37455 FlyBaseID:FBgn0003731 Length:1426 Species:Drosophila melanogaster
Sequence 2:NP_477255.1 Gene:Nrk / 36445 FlyBaseID:FBgn0020391 Length:724 Species:Drosophila melanogaster


Alignment Length:629 Identity:146/629 - (23%)
Similarity:245/629 - (38%) Gaps:183/629 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   717 WEYVHPQEQGSLKPLAGRAVCRKCHPLCELCTNYGYHEQVCSKCTHYKRREQCETECPADH---- 777
            |:.:.....|..:..|.:.:|....|.|.:.........:|.:            :|.|.|    
  Fly   107 WDELISDLTGLCREAAEKMLCAYAFPNCHMEGGRAVKAPLCFE------------DCQATHLQFC 159

  Fly   778 YTD------EEQRECF---QCH---PECN------------GCTGPGADDCK------SCRNFKL 812
            |.|      :::|..|   :.|   |.|:            .|:..|..:.|      .||    
  Fly   160 YNDWVLIEEKKERNMFIKSRGHFRLPNCSSLPHYNASMRRPNCSYIGLTELKESEVSYDCR---- 220

  Fly   813 FDANETGPYVNSTMFNCTSKCPLEMRHVNYQYTAIGP------------YCAAS----------- 854
               |..|.:...||....|..|.:.....|.:....|            ||..:           
  Fly   221 ---NGNGRFYMGTMNVSKSGIPCQRWDTQYPHKHFQPPLVFHQLLEGENYCRNAGGEEPHPWCYT 282

  Fly   855 ------------PPRSSKITAN-LDVN------------MIFIITGA--VLVPTICILCVVTY-I 891
                        |.....:..| :|:|            |||::.|.  |.:.|:.::.::.| :
  Fly   283 VDESVRWQHCDIPMCPDYVDPNAVDLNTPIKMEKFFTPSMIFLLAGIGFVAIVTLHLMILLVYKL 347

  Fly   892 CRQK---QKAKKETVKMTMALSG---CEDSEPLRPSNIGAN------------------------ 926
            .:.|   |.|...|.:.::::.|   |..:.......:|.|                        
  Fly   348 SKHKDYSQPAGAATAECSVSMRGGGDCGGNLNTSRETLGGNGNTNTLAKWGTIRSTATIHSNCVA 412

  Fly   927 LCKLRIVKDA------------ELRKGGV-----LGMGAFGRVYK----GVWVPEGENVKIPVAI 970
            |..:..|.||            |..:|.:     ||.||||||::    |: ||:.|:  :.||:
  Fly   413 LTTVTNVSDAKGTKPNARLEKLEYPRGDIVYVRSLGQGAFGRVFQARAPGL-VPDQED--LLVAV 474

  Fly   971 KELLKSTGAESSEEFLREAYIMASVEHVNLLKLLAVC-MSSQMMLITQLMPLGCLLDYVR----- 1029
            |.|......:...:|.|||.::|..:|.|:::||.|| :...|.|:.:.|..|.|.:::|     
  Fly   475 KMLKDDASDQMQMDFEREACLLAEFDHPNIVRLLGVCALGRPMCLLFEYMAPGDLSEFLRACSPY 539

  Fly  1030 -------NNRDKIGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKL 1087
                   .:|.::....||..:..||.||.||.|::.||||||.||.|:.....|||.||||:..
  Fly   540 ATHQAPTQDRLQLNELHLLQMAANIAAGMLYLSERKFVHRDLATRNCLINEHMAVKIADFGLSHK 604

  Fly  1088 L------SSDSNEYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPA 1146
            :      ..|.|::      :||:|:.||.|....|:.:|||||:|:.:||:.:|..:|:..:..
  Fly   605 IYLQDYYKGDENDF------IPIRWMPLESILYNKFSLESDVWAYGICLWEVFSFALQPYFGLTH 663

  Fly  1147 KDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQL 1190
            :::...|:.|..|..|:...|.:|..:..||:...:.||.|.::
  Fly   664 EEVIKYIKEGNVLGCPDNTPLSVYALMRRCWNRKPSERPGFAEI 707

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EgfrNP_476759.1 Recep_L_domain 128..239 CDD:460032
Furin-like 253..401 CDD:395614
Recep_L_domain 419..547 CDD:460032
GF_recep_IV 572..684 CDD:464344
FU 662..716 CDD:214589
GF_recep_IV 740..>834 CDD:464344 23/127 (18%)
PTKc_EGFR_like 930..1208 CDD:270648 94/301 (31%)
NrkNP_477255.1 CRD_FZ 67..212 CDD:470581 19/116 (16%)
KR 217..299 CDD:214527 13/88 (15%)
PTKc_Musk 435..713 CDD:133181 91/282 (32%)
Blue background indicates that the domain is not in the aligned region.

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