Protein Alignment Egfr and Src42A

DIOPT Version :10

• Sequence 1: NP_476759.1
• Gene: Egfr / 37455
• FlyBaseID: FBgn0003731
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: NP_001400996.1
• Gene: Src42A / 35524
• FlyBaseID: FBgn0264959
• Length: 1606
• Species: Drosophila melanogaster
• Alignment Length: 1075
• Identity: 238/1075 - (22%)
• Similarity: 376/1075 - (34%)
• Gaps: 372/1075 - (34%)

  Fly   237 EIVSNGTDAYYNYDFTAPERECPKCHESCTHGCWGE-----GPKNCQKFSKLTCSPQCAGGRCYG 296
            :|:....|.|..||            :..|:|...|     ..::...:.:.:.|....|||..|
  Fly   811 DIIQRKNDIYQKYD------------KYMTYGTIYEILHRKTSQSSDPWQRKSLSSILEGGRSSG 863

  Fly   297 PKPRECCHLFCAGGCTGPTQKDCIACKNFFDEGVCKEECPPMRKYNPTTYVLETNPEGKYAYGAT 361
                                 |.|     :|.|..:|........:.:..|...||   :.||..
  Fly   864 ---------------------DII-----YDIGQRRERDKRTLGSSSSATVSTINP---HKYGTI 899

  Fly   362 C-----VKECPGHLLRDNGACVRSCPQDK---------------------------MDKGGECVP 394
            .     ||...||        |::.|..|                           .|:.|:.|.
  Fly   900 YDILQGVKIDAGH--------VKNKPDQKSKPTKPPLAKPTRFVVSQVVEPVQIPPTDQSGKSVQ 956

  Fly   395 CNGPCPKTCPGVTVLHAGNIDSFRNCTVIDGNIRILDQTFSGFQDVYANYTMGPRYI-------P 452
            ..| .||:.....:....||.|:...:..|      .|..:|.::.....|...|.|       |
  Fly   957 EQG-APKSNKPNKMRRLSNILSYSRNSGED------QQETTGKEETKPKRTQAKRRIGVTNLLLP 1014

  Fly   453 LDPERLEVFSTVKEITGYLNIEGTHPQFRNLSYFRNLETIHGRQ------LMESMFAALAIVKSS 511
            ||.|.|           |..|         ::..|.|:..|.::      ..|.|....|:.|||
  Fly  1015 LDSEEL-----------YTRI---------IAQQRGLDKEHSQEPEEKCASEEQMCTRNALTKSS 1059

  Fly   512 LYSLEMRNLKQISSGSVVIQHNRDLCYVSNIRWPAIQKEP-------EQKVWVNENLRADLCEKN 569
              ||:..:|      ||.|.             ||....|       :|...:.::.:..|.:|:
  Fly  1060 --SLDAISL------SVAIS-------------PASSPSPPRPRRSLKQHRCLQQHQQTPLAKKH 1103

  Fly   570 GTICSDQCNEDGCWGAGTDQCLTCKNFNFNGTCIADCGYISNAYKFDNRT---CKICHPECRTCN 631
                            ..|.||         ..::.........::.|:|   | .|||
  Fly  1104 ----------------SLDNCL---------QVVSSTTSRQPLRRWSNQTPLKC-TCHP------ 1136

  Fly   632 GAGADHCQECVHVRDGQHCVSECPKNKY-NDRGVCRECHATCDGCTGPKDTIGIGACTTCNLAII 695
                              ...|.|.... ..|.:...|.|:|             :.|..:|::|
  Fly  1137 ------------------ATEELPLTAIEKSRSLPAACSASC-------------SHTCAHLSVI 1170

  Fly   696 NNDATVKRCLLKDDKCPDGYFWEYVHPQEQGSLKPLAGRAVCRKCHPLCELCTNYGYHEQVCSKC 760
            :......:|..|..          :...::|..:.|                :.:...|.:..|.
  Fly  1171 DQSPATTKCFGKTS----------LTTAKKGKSRRL----------------SEFTRGEFLNEKS 1209

  Fly   761 THYKRREQCETE----CPADHY-----TDEEQRECFQCHPECNGCTGPGADDCKSCRNFKLFDAN 816
            .::::.::.|.|    .|.:.:     .|.|.|     |.:.:    ....|..:.:::::...:
  Fly  1210 WYFRKIKRIEAEKKLLLPENEHGAFLIRDSESR-----HNDYS----LSVRDGDTVKHYRIRQLD 1265

  Fly   817 ETGPYV-NSTMFNCTSKCPLEMRHVNYQYTAIGPYCAASPPRSSKITANLDVNMIFIITGAVLVP 880
            |.|.:: ..|.|....:.   :.|.                  ||.:..|.||
  Fly  1266 EGGFFIARRTTFRTLQEL---VEHY------------------SKDSDGLCVN------------ 1297

  Fly   881 TICILCVVTYICRQKQKAKKETVKMTMALSGCEDSEPLRPSNIG----------ANLCKLRIVKD 935
             :|..||                 .|.:.||..:.|  :|...|          .:...|:.|:.
  Fly  1298 -LCKPCV-----------------QTNSFSGVFEIE--KPVTEGLSHRTRDQWEIDRTSLKFVRK 1342

  Fly   936 AELRKGGVLGMGAFGRVYKGVWVPEGENVKIPVAIKELLKSTGAESSEEFLREAYIMASVEHVNL 1000
                    ||.|.||.|::|:|     |...|||||.|  .:|....::||.||.||..:.|..|
  Fly  1343 --------LGSGQFGDVWEGLW-----NNTTPVAIKTL--KSGTMDPKDFLAEAQIMKKLRHTKL 1392

  Fly  1001 LKLLAVC-MSSQMMLITQLMPLGCLLDYVRNNRDK---IGSKALLNWSTQIAKGMSYLEEKRLVH 1061
            ::|.||| :...:.:||:||..|.||:|::....|   :..:.|::.:.|||.||:|||.:..:|
  Fly  1393 IQLYAVCTVEEPIYIITELMKHGSLLEYLQAIAGKGRSLKMQTLIDMAAQIAAGMAYLESQNYIH 1457

  Fly  1062 RDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKA-AGGKMPIKWLALECIRNRVFTSKSDVWA 1125
            ||||||||||...::|||.|||||:|:..|  ||:| .|.:.||||.|.|......|:.|||||:
  Fly  1458 RDLAARNVLVGDGNIVKIADFGLARLIKED--EYEARVGARFPIKWTAPEAANYSKFSIKSDVWS 1520

  Fly  1126 FGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQL 1190
            ||:.:.||:|:|:.|:..:...::...:|.|.::.||..|...:|..:|.|||.|...||||:.|
  Fly  1521 FGILLTELVTYGRIPYPGMTNAEVLTQVEHGYRMPQPPNCEPRLYEIMLECWHKDPMRRPTFETL 1585

  Fly  1191 TTVFAEFARDPGRYLAIPGDKFTRLPAYTSQDEKD 1225
            .....:|                    ||| |:.|
  Fly  1586 QWKLEDF--------------------YTS-DQSD 1599

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Egfr	NP_476759.1	Recep_L_domain	128..239	CDD:460032	0/1 (0%)
		Furin-like	253..401	CDD:395614	29/184 (16%)
		Recep_L_domain	419..547	CDD:460032	29/140 (21%)
		GF_recep_IV	572..684	CDD:464344	15/115 (13%)
		FU	662..716	CDD:214589	9/53 (17%)
		GF_recep_IV	740..>834	CDD:464344	14/103 (14%)
		PTKc_EGFR_like	930..1208	CDD:270648	109/282 (39%)
Src42A	NP_001400996.1	SH2_Src_Src42	1210..1301	CDD:198233	19/133 (14%)
		PTKc_Frk_like	1328..1596	CDD:270653	112/305 (37%)