Protein Alignment Egfr and IGF1R

DIOPT Version :10

• Sequence 1: NP_476759.1
• Gene: Egfr / 37455
• FlyBaseID: FBgn0003731
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: XP_016877626.1
• Gene: IGF1R / 3480
• HGNCID: 5465
• Length: 1392
• Species: Homo sapiens
• Alignment Length: 1461
• Identity: 319/1461 - (21%)
• Similarity: 518/1461 - (35%)
• Gaps: 498/1461 - (34%)

  Fly   119 YRNLRDRYTNCTYVDGNLELTWLPNENLDLSF-LDNIREVTGYILISHV---DVKKVVFPKLQII 179
            |:.|: |..|||.::|.|.:..:.......|: ...:..:|.|:|:..|   :....:||.|.:|
Human    68 YQQLK-RLENCTVIEGYLHILLISKAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVI 131

  Fly   180 RGRTLFSLSVEEEKYALFV-TYSKMYTLEIPDLRDVLNGQVGFHNNYNLCHMRTIQWS---EIVS 240
            ||..||      ..|||.: ..:.:..:.:.:||::..|.:....|.:||::.|:.||   :.||
Human   132 RGWKLF------YNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAVS 190

  Fly   241 NGTDAYYNYDF-TAPEREC-----------PKCHESC-----THGCWGEGPKNCQKFSKLTCSPQ 288
            |      ||.. ..|.:||           |.|.::.     .:.||  ....|||....||
Human   191 N------NYIVGNKPPKECGDLCPGTMEEKPMCEKTTINNEYNYRCW--TTNRCQKMCPSTC--- 244

  Fly   289 CAGGRCYGPKPRECCHLFCAGGCTGP-TQKDCIACKNFFDEGVCKEECPPMRKYNPTTYVLETNP 352
               |:....:..||||..|.|.|:.| ....|:||::::..|||...||      |.||..|
Human   245 ---GKRACTENNECCHPECLGSCSAPDNDTACVACRHYYYAGVCVPACP------PNTYRFE--- 297

  Fly   353 EGKYAYGATCV-------------KECPGHLLRDNGACVRSCPQDKMDKGGE---CVPCNGPCPK 401
                  |..||             .:..|.::.| |.|::.||...:..|.:   |:||.|||||
Human   298 ------GWRCVDRDFCANILSAESSDSEGFVIHD-GECMQECPSGFIRNGSQSMYCIPCEGPCPK 355

  Fly   402 TC----PGVTVLHAGNIDSFRNCTVIDGNIRILDQTFSGFQDVYANYTMGPRYIPLDPERLEVFS 462
            .|    ...|:....:....:.||:..||:.|..:..:.......|: ||
Human   356 VCEEEKKTKTIDSVTSAQMLQGCTIFKGNLLINIRRGNNIASELENF-MG--------------- 404

  Fly   463 TVKEITGYLNIEGTHPQFRNLSYFRNLETIHGRQLMESMFAALAIVKSSLYSLEMRNLKQ----- 522
            .::.:|||:.|..:| ...:||:.:||..|.|.:.:|..:        |.|.|:.:||:|
Human   405 LIEVVTGYVKIRHSH-ALVSLSFLKNLRLILGEEQLEGNY--------SFYVLDNQNLQQLWDWD 460

  Fly   523 -----ISSGSVVIQHNRDLCYVSNIRWPAIQKEPEQKVWVNENLRADLCEKNGTICSDQCNEDGC 582
                 |.:|.:....|..||                   |:|..|.:  |..||
Human   461 HRNLTIKAGKMYFAFNPKLC-------------------VSEIYRME--EVTGT----------- 493

  Fly   583 WGAGTDQCLTCKNFNFNGTCIADCGYISNAYKFDNRTCKICH----PECRTCNGAGADHCQECVH 643
            .|..:...:..:|.....:|.:|..:.::.....||.....|    |:.|       |.....|:
Human   494 KGRQSKGDINTRNNGERASCESDVLHFTSTTTSKNRIIITWHRYRPPDYR-------DLISFTVY 551

  Fly   644 VR----------DGQH-CVS--------ECPKNKYNDRGVCRECHATCDGCTGPKD----TIGIG 685
            .:          |||. |.|        :.|.||..:.|:...         |.|.    .:.:.
Human   552 YKEAPFKNVTEYDGQDACGSNSWNMVDVDLPPNKDVEPGILLH---------GLKPWTQYAVYVK 607

  Fly   686 ACTTCNLAIINND---------------ATV--------------KRCLLK--DDKCPDGYFWEY 719
            |.|   |.::.||               |:|              .:.::|  ....|:|....|
Human   608 AVT---LTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGNLSYY 669

  Fly   720 -VHPQEQGSLKPLAGRAVCRKC-------------------HPLCELCTNYGYHEQVCSKCTHYK 764
             |..|.|.....|.....|.|.                   :|..|:|   |..:..|..|...:
Human   670 IVRWQRQPQDGYLYRHNYCSKDKIPIRKYADGTIDIEEVTENPKTEVC---GGEKGPCCACPKTE 731

  Fly   765 RREQCETE-------------------------------------------CPADHY--TDEEQR 784
            ..:|.|.|                                           ..||.|  ||.|:.
Human   732 AEKQAEKEEAEYRKVFENFLHNSIFVPRPERKRRDVMQVANTTMSSRSRNTTAADTYNITDPEEL 796

  Fly   785 EC----FQCHPE----------------------CN------GCT-----------GPGADD--- 803
            |.    |:...:                      ||      ||:           ..||||
Human   797 ETEYPFFESRVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGADDIPG 861

  Fly   804 ------------------------------------------CKSCRNF---------KLFDANE 817
                                                      |.|.:.:         :|...|.
Human   862 PVTWEPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPGNY 926

  Fly   818 T-----------GPYVNSTMFNCTSKCPLEMRHVNYQYTAIGPYCAASPPRSSKITANLDVNMIF 871
            |           |.:.:...|...:|...|    |:.:..|.                |.|.::.
Human   927 TARIQATSLSGNGSWTDPVFFYVQAKTGYE----NFIHLIIA----------------LPVAVLL 971

  Fly   872 IITGAVLVPTICILCVVTYICRQKQKAKKETVKMTMALSGCEDSEPLRPSNIGA---------NL 927
            |:.|         |.::.|:..:|:...:....:..|        .:.|....|         .:
Human   972 IVGG---------LVIMLYVFHRKRNNSRLGNGVLYA--------SVNPEYFSAADVYVPDEWEV 1019

  Fly   928 CKLRIVKDAELRKGGVLGMGAFGRVYKGVWVPEG---ENVKIPVAIKELLKSTGAESSEEFLREA 989
            .:.:|....|      ||.|:||.||:|  |.:|   :..:..||||.:.::.......|||.||
Human  1020 AREKITMSRE------LGQGSFGMVYEG--VAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEA 1076

  Fly   990 YIMASVEHVNLLKLLAVCMSSQ-MMLITQLMPLGCLLDYVRNNRDKIGSKALL---------NWS 1044
            .:|......::::||.|....| .::|.:||..|.|..|:|:.|.::.:..:|         ..:
Human  1077 SVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMA 1141

  Fly  1045 TQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAGGK--MPIKWL 1107
            .:||.||:||...:.|||||||||.:|.....|||.|||:.:.:.  ..:|...|||  :|::|:
Human  1142 GEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIY--ETDYYRKGGKGLLPVRWM 1204

  Fly  1108 ALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCT 1172
            :.|.:::.|||:.||||:|||.:||:.|..::|::.:..:.:...:..|..|::|:.|...::..
Human  1205 SPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFEL 1269

  Fly  1173 LLSCWHLDAAMRPTFKQLTTVFAEFARDPGRYLAIPGDKFTRLPAYTSQDEK-------DLIRK- 1229
            :..||..:..|||:|.::.:...| ..:||         |..:..|.|::.|       ||..:
Human  1270 MRMCWQYNPKMRPSFLEIISSIKE-EMEPG---------FREVSFYYSEENKLPEPEELDLEPEN 1324

  Fly  1230 -----LAPTTDGSEAIAEPDDYLQPKAAPGP 1255
                 |.|:. .|.::..||.:...||..||
Human  1325 MESVPLDPSA-SSSSLPLPDRHSGHKAENGP 1354

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Egfr	NP_476759.1	Recep_L_domain	128..239	CDD:460032	30/118 (25%)
		Furin-like	253..401	CDD:395614	49/180 (27%)
		Recep_L_domain	419..547	CDD:460032	31/137 (23%)
		GF_recep_IV	572..684	CDD:464344	22/138 (16%)
		FU	662..716	CDD:214589	13/88 (15%)
		GF_recep_IV	740..>834	CDD:464344	33/265 (12%)
		PTKc_EGFR_like	930..1208	CDD:270648	91/292 (31%)
IGF1R	XP_016877626.1	Recep_L_domain	76..186	CDD:460032	30/115 (26%)
		Furin-like	200..355	CDD:395614	48/178 (27%)
		Recep_L_domain	377..492	CDD:460032	35/160 (22%)
		FN3	519..631	CDD:238020	23/130 (18%)
		FN3	636..>680	CDD:238020	7/43 (16%)
		FN3	860..949	CDD:238020	7/88 (8%)
		PTKc_InsR_like	1017..1293	CDD:173625	88/285 (31%)