DRSC/TRiP Functional Genomics Resources

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Protein Alignment Egfr and Pvr

DIOPT Version :9

Sequence 1:NP_476759.1 Gene:Egfr / 37455 FlyBaseID:FBgn0003731 Length:1426 Species:Drosophila melanogaster
Sequence 2:NP_001162911.1 Gene:Pvr / 34127 FlyBaseID:FBgn0032006 Length:1577 Species:Drosophila melanogaster


Alignment Length:1324 Identity:263/1324 - (19%)
Similarity:419/1324 - (31%) Gaps:530/1324 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly   406 VTVLHAGNIDS-FRNCTVIDGN----------IRILDQTF--------SGFQDV--YANYTMGPR 449
            :|||:|...|: ...|...|.:          |::|.|..        ||..:|  |||.|:   
  Fly   398 LTVLNAQPSDTGLYKCVTTDNSNQNVQRATYRIKVLKQNESYLNVGEPSGHYNVQEYANRTI--- 459

  Fly   450 YIPLDPERLEVFSTVKEITGYLNIEG-THPQFRNLSYFRNLETIHGRQLMESMFAALAIVKSSLY 513
                            ::|.  |.|| ..|.|   |:|:. :....|| .|:.|..|:...|:: 
  Fly   460 ----------------QMTA--NFEGFPTPSF---SWFKP-DGTEVRQ-SENNFKILSTELSTM- 500

  Fly   514 SLEMRNLKQISSGSVVIQHNRDL------CYVSNIRWPAIQKEPEQKVWVNENLRADLCEKN--- 569
             |::.|.:...||:.|::.:...      ..||.:..||: |..:..|.|....|.:...::   
  Fly   501 -LQVLNAQLQDSGTYVLRGSNSFGVVQREYNVSVMDAPAL-KMSDAYVQVGSVARLECTVRSYPP 563

  Fly   570 --GTICSDQCNEDGCWGAGTDQCLTCKNFNFNGTCIADCGYISNAYKFDNR-------------- 618
              .|.....|:.:..|.       ||...|.|.:..::    ...|:|..|              
  Fly   564 AIVTFFFRPCSLEPQWP-------TCSVLNQNFSLPSE----QEKYQFQTRPRPGKLSVERIYEV 617

  Fly   619 ----------TC----KICHPECRTCNGAGADHCQECVHVRDGQHCVSECPKNKY---NDRGVCR 666
                      ||    .|...|.||...|         ||..|.  :|| ....|   .|..:.:
  Fly   618 SFLPTEPGILTCIAQNIIDGKERRTLTKA---------HVLLGN--ISE-NMTIYGFDKDHKIAK 670

  Fly   667 ECHATCDGCTGPKDTIGIGACTTCNLAIINNDATVKRCLLKDD-KCPDGYFWEYVHPQEQGSLKP 730
            |            |.:..    ||.....:.|..:|..:..:| |..|....|..|         
  Fly   671 E------------DNVNF----TCEALAYHFDGNLKWFINGEDLKESDSVHIETSH--------- 710

  Fly   731 LAGRAVCRKCHPLCELCTNYGYHEQVCSKCTHYKRREQCETECPADH------YTDEEQRECFQC 789
                             |.|.|...|  ..|....|::...||.|.|      |:..| .:.:..
  Fly   711 -----------------TKYSYKSTV--HITTISDRDRGTYECRAYHNDKDAVYSSRE-IDLYVH 755

  Fly   790 HPECNGCTGPGAD---------------DCKS-------CRNFK--------------------- 811
            .|.....|..|.:               :|.|       .|.||                     
  Fly   756 DPSAPQWTNGGQEGHSKIKRKLSQTLELECASTAVPVAIVRWFKDDKEVTESKLRHIIEKESKLL 820

  Fly   812 ---LFDANETGPYVNSTMFNCTSKCPLEMR--HVNYQYTAIGPYCAASPPRSSKITANLDVNMIF 871
               |:..:| |.|          ||.:|.|  .:...:|.:             |:....::|.:
  Fly   821 ITHLYPGDE-GVY----------KCVVENRLDRIERSFTVV-------------ISDLPGISMAW 861

  Fly   872 IITGAVLVPTICILCVVTYICRQKQKAKKETVKMTMALSGCEDSEPLRPSNIGANLCKLRIVKDA 936
            :..|.:|...:..|||...:..||:. |:........|:..|:..      :|.....|.:.:.|
  Fly   862 VWFGVILFLILIGLCVFLAVRYQKEH-KRHLALKAAGLANFEEGA------VGHINPDLTLDEQA 919

  Fly   937 E--------------LRKGGVLGMGAFGRVYKGVWVPEGENVK-----IPVAIKELLKSTGAESS 982
            |              |:.|..||.||||.|.||    |.:.::     ..||:|.:..:...|..
  Fly   920 ELLPYNREFEFPRENLKLGKQLGAGAFGVVLKG----EAKGIRREEPTTTVAVKMVKATADNEVV 980

  Fly   983 EEFLREAYIMASV-EHVNLLKLLAVCMSS----QMMLITQLMPLG-----------CLLDYVRNN 1031
            ...:.|..||..: :|:|::.||.....:    ::|:|.:....|           |.::.:..:
  Fly   981 RALVSELKIMVHLGQHLNVVNLLGAVTKNIAKRELMVIVEYCRFGNIQNFLLRNRKCFINQINPD 1045

  Fly  1032 RDKI------------------------------------------------------------G 1036
            .|.|                                                            |
  Fly  1046 TDHIDPSIMTQRMSDNYELHRDTNGGGLKYANVGFPIHSYINEPHNNNTQPPTHRRNSDNDPRSG 1110

  Fly  1037 SKA------------------------------------------------------------LL 1041
            ::|                                                            |:
  Fly  1111 TRAGRTGSGTATYSYDRQMDTCATVMTTVPEDDQIMSNNSVQPAWRSNYKTDSTEAMTVTTVDLI 1175

  Fly  1042 NWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAGGKMPIKW 1106
            :|:.|:|:||.||..|:::|.||||||:|:...::|||.|||||:.:....|..|:..||:||||
  Fly  1176 SWAFQVARGMDYLSSKKVLHGDLAARNILLCEDNVVKICDFGLARSMYRGDNYKKSENGKLPIKW 1240

  Fly  1107 LALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENI-PAKDIPDLIEVGLKLEQPEICSLDIY 1170
            ||||.:.:.||::.||||::|:.:||:.:..:.|:..| |.:::.:.:..|.::|:|:..:.::|
  Fly  1241 LALESLSDHVFSTYSDVWSYGIVLWEMFSLAKVPYPGIDPNQELFNKLNDGYRMEKPKFANQELY 1305

  Fly  1171 CTLLSCWHLDAAMRPTFKQLTTVFA-----------------------EFARDPGR-YLAIPGDK 1211
            ..:|.||..:...||.|.:|...||                       |:.:.... |||:.|  
  Fly  1306 EIMLECWRKNPESRPLFAELEKRFANMLGEDVASHYLDLNNPYMQSNIEYMKKQSTDYLALMG-- 1368

  Fly  1212 FTRLPAYTSQDEKDLIRKLAPTTDGSEAIAE------PDDYLQ---------------PKAAPG- 1254
                    |.||   :...||.......:.:      ||||::               |....| 
  Fly  1369 --------SPDE---LAPAAPRYVNGHIVPDIRIEELPDDYMEMSRDSDPDACTAIFSPTRLEGE 1422

  Fly  1255 ----PSHRTDCTDEIP----------KLNRYCKDPSNK---------------------NSSTGD 1284
                |...::.|...|          .||.....|..|                     .||||.
  Fly  1423 SSDFPDFSSETTFNFPGARQSPTLSNNLNSGSSKPLRKKNGMPTVDVADQAPEEIPMLHRSSTGS 1487

  Fly  1285 DETDSSAREVGVGNLRLDLPVDEDDYLMPTCQP---------GPNNNNNINN-------PNQNNM 1333
            |.:....|..   |..|     :..|:.||..|         |..:.|.:|.       |.:...
  Fly  1488 DGSPEQGRRF---NQAL-----KQQYVTPTPSPRHHVETKLNGEPSENYVNMKPPRKNIPGKTTT 1544

  Fly  1334 AAVGVAAGYMDLIGVPVSVDNPEY 1357
            ...|.|||     ....:..||.|
  Fly  1545 GGGGAAAG-----ASTEAFSNPSY 1563

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EgfrNP_476759.1 Recep_L_domain 419..547 CDD:279382 34/154 (22%)
GF_recep_IV 572..684 CDD:291509 25/142 (18%)
FU 573..>606 CDD:238021 6/32 (19%)
FU 617..659 CDD:214589 13/69 (19%)
FU 662..716 CDD:214589 9/54 (17%)
FU 739..786 CDD:238021 12/52 (23%)
FU 784..834 CDD:214589 13/95 (14%)
PTKc_EGFR_like 930..1208 CDD:270648 100/457 (22%)
STYKc 938..1194 CDD:214568 91/397 (23%)
Recep_L_domain 128..239 CDD:279382
Furin-like 253..401 CDD:279142
FU 255..292 CDD:214589
FU 302..345 CDD:238021
PvrNP_001162911.1 IG 346..432 CDD:214652 8/33 (24%)
Ig <363..432 CDD:299845 8/33 (24%)
Ig 466..533 CDD:299845 18/73 (25%)
IG_like 672..754 CDD:214653 22/114 (19%)
Ig 674..739 CDD:143165 18/96 (19%)
IGc2 779..840 CDD:197706 12/71 (17%)
PKc_like 927..1332 CDD:304357 93/408 (23%)
Pkinase_Tyr 935..1329 CDD:285015 91/397 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45455285
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR24416
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
22.030

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