DRSC/TRiP Functional Genomics Resources

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Protein Alignment Egfr and sev

DIOPT Version :10

Sequence 1:NP_476759.1 Gene:Egfr / 37455 FlyBaseID:FBgn0003731 Length:1426 Species:Drosophila melanogaster
Sequence 2:NP_511114.2 Gene:sev / 32039 FlyBaseID:FBgn0003366 Length:2554 Species:Drosophila melanogaster


Alignment Length:422 Identity:132/422 - (31%)
Similarity:204/422 - (48%) Gaps:69/422 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly   821 YVNSTMFNCTSKCPLEMRHVNYQYTA------IGPYC-----AASPPRSSKITANLDVNMIFIIT 874
            :.|:|..:|..|.....|.:.::..|      .|||.     .|.|..|.:...:|   ::.||.
  Fly  2071 FCNTTELSCIVKSLHSSRLLLFRVRARSLEHGWGPYSEESERVAEPFVSPEKRGSL---VLAIIA 2132

  Fly   875 GAVLVPTICILCVVTYICRQKQK----AKK----------------ETVKMTMALSGCEDSEPLR 919
            .|.:|.: |:|.:|  :.|:.||    |||                :|.:..||:.....|..|.
  Fly  2133 PAAIVSS-CVLALV--LVRKVQKRRLRAKKLLQQSRPSIWSNLSTLQTQQQLMAVRNRAFSTTLS 2194

  Fly   920 PSNIG----ANLCKLRIVKDAELRKGGVLGMGAFGRVYKGVWVPEGENVKIPVAIKELLKSTGAE 980
            .::|.    .|..:|::::        .||.||||.||:|....|.......||||.|.|  ||.
  Fly  2195 DADIALLPQINWSQLKLLR--------FLGSGAFGEVYEGQLKTEDSEEPQRVAIKSLRK--GAS 2249

  Fly   981 SSEEFLREAYIMASVEHVNLLKLLAVCMSSQ-MMLITQLMPLGCLLDYVRNNRDK---------- 1034
            ...|.|:||.:|::.:|.|::.|:.:|..:: :.||.:.|..|.||.|:|..|..          
  Fly  2250 EFAELLQEAQLMSNFKHENIVCLVGICFDTESISLIMEHMEAGDLLSYLRAARATSTQEPQPTAG 2314

  Fly  1035 IGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPS-------LVKITDFGLAKLLSSDS 1092
            :....||.....:|.|.||||:...||||||.||.||...:       .|||.|||||:.:....
  Fly  2315 LSLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIYKSD 2379

  Fly  1093 NEYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGL 1157
            ...|...|.:|::|::.|.:.:.:||::||||||||..||:||.||:|:......::...::.|.
  Fly  2380 YYRKEGEGLLPVRWMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHVKEGG 2444

  Fly  1158 KLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQ 1189
            :|:||.:|:..:|..||.||..|...||:|::
  Fly  2445 RLQQPPMCTEKLYSLLLLCWRTDPWERPSFRR 2476

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EgfrNP_476759.1 Recep_L_domain 128..239 CDD:460032
Furin-like 253..401 CDD:395614
Recep_L_domain 419..547 CDD:460032
GF_recep_IV 572..684 CDD:464344
FU 662..716 CDD:214589
GF_recep_IV 740..>834 CDD:464344 4/12 (33%)
PTKc_EGFR_like 930..1208 CDD:270648 99/278 (36%)
sevNP_511114.2 fn3 439..520 CDD:394996
FN3 826..921 CDD:238020
Vgb 992..>1118 CDD:443399
LY 993..1026 CDD:214531
FN3 1292..1374 CDD:214495
fn3 1800..1891 CDD:394996
FN3 1993..2111 CDD:238020 9/39 (23%)
PTKc_c-ros 2213..2483 CDD:270640 98/274 (36%)
Blue background indicates that the domain is not in the aligned region.

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